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Estrogen Receptor-Mediated Gene Transcription and Cistrome

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Estrogen Receptor and Breast Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The discovery of the estrogen receptor 60 years ago radically transformed the field of hormonal signaling and led to the recognition of ER as a prototype nuclear receptor that primarily functions as a transcription factor. In this chapter, we will first describe the conserved domain architecture of ER and its regulation through various modifications by diverse intracellular pathways. We will then discuss the history and most recent advancement in the understanding of ER regulation of target genes at both individual gene and whole genome levels. A number of new concepts emanated from these studies, including ER cistrome, pioneer factors, chromosome looping and enhancer RNA, etc. and their potential impact on the fight against breast cancer therapeutic resistance all will be discussed in detail in this chapter.

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Acknowledgments

We thank Zhang lab members for helpful discussion and Mr. Glenn Doerman for figure illustrations. This study was supported by NCI R01 CA197865, University of Cincinnati Cancer Center Startup and College of Medicine Innovation Seed Grant (to X.Z). G.B was supported by NCI training grant T32CA117846.

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  1. Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Gregory Bick & Dan Zhao

  2. Department of Cancer Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Xiaoting Zhang

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    Xiaoting Zhang

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Bick, G., Zhao, D., Zhang, X. (2019). Estrogen Receptor-Mediated Gene Transcription and Cistrome. In: Zhang, X. (eds) Estrogen Receptor and Breast Cancer. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-319-99350-8_3

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