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Pro-Angiogenic Regenerative Therapies for the Damaged Brain: A Tissue Engineering Approach

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Book cover Biophysical Regulation of Vascular Differentiation and Assembly

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Angiogenesis in the stroke brain has been increasingly recognized as a key player in tissue repair, endogenous neurogenesis, and functional recovery. Important findings in the last decade have shown that promoting the formation of a mature and functional vascular network in a wound that is dynamic in space and time represents one of the biggest challenges in pro-repair therapies after stroke. Recent preclinical studies of therapeutic angiogenesis have been introducing tissue engineering-based systems that allow precisely controlled delivery of provascular drugs directly to the site of damage, without inducing the commonly associated side effects.

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Author information

Authors and Affiliations

  1. Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

    Lina R. Nih & Stanley T. Carmichael

  2. Department of Biomedical Engineering, Neurology, Dermatology, Pratt School of Engineering, Duke University, Durham, NC, USA

    Tatiana Segura

Authors
  1. Lina R. Nih
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  2. Stanley T. Carmichael
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  3. Tatiana Segura
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Corresponding authors

Correspondence to Lina R. Nih or Tatiana Segura .

Editor information

Editors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences–Oncology Center and Institute for NanoBioTechnology, Baltimore, MD, USA

    Sharon Gerecht

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Nih, L.R., Carmichael, S.T., Segura, T. (2018). Pro-Angiogenic Regenerative Therapies for the Damaged Brain: A Tissue Engineering Approach. In: Gerecht, S. (eds) Biophysical Regulation of Vascular Differentiation and Assembly. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-99319-5_7

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