Pain pp 37-40 | Cite as

Peripheral Mechanisms of Pain Transmission and Modulation

  • Thomas S. McDowellEmail author


Primary nociceptive neurons are specialized sensory neurons that respond to noxious physical stimuli. Information about painful stimuli is transmitted to the central nervous system by action potentials, which travel from the periphery along either unmyelinated (C-fiber) or thinly myelinated (Aδ-fiber) nociceptor axons to the central nervous system to signal the painful stimulus. Nociceptors can become sensitized by inflammatory mediators, leading to primary hyperalgesia.


Nociceptor Action potential Sensitization Hyperalgesia Inflammatory pain 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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