Peripheral Mechanisms of Pain Transmission and Modulation
Primary nociceptive neurons are specialized sensory neurons that respond to noxious physical stimuli. Information about painful stimuli is transmitted to the central nervous system by action potentials, which travel from the periphery along either unmyelinated (C-fiber) or thinly myelinated (Aδ-fiber) nociceptor axons to the central nervous system to signal the painful stimulus. Nociceptors can become sensitized by inflammatory mediators, leading to primary hyperalgesia.
KeywordsNociceptor Action potential Sensitization Hyperalgesia Inflammatory pain
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