Abstract
Primary nociceptive neurons are specialized sensory neurons that respond to noxious physical stimuli. Information about painful stimuli is transmitted to the central nervous system by action potentials, which travel from the periphery along either unmyelinated (C-fiber) or thinly myelinated (Aδ-fiber) nociceptor axons to the central nervous system to signal the painful stimulus. Nociceptors can become sensitized by inflammatory mediators, leading to primary hyperalgesia.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ringkamp M, Raja SN, Campbell JN, Meyer RA. Peripheral mechanisms of cutaneous nociception. In: McMahon SB, Koltzenburg M, Tracey I, Turk DC, editors. Wall and Melzack’s textbook of pain. 6th ed. Philadelphia: Saunders; 2013. p. 1–30.
Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139:267–84.
Dubin AE, Patapoutian A. Nociceptors: the sensors of the pain pathway. J Clin Invest. 2010;120:3760–72.
Hua S. Neuroimmune interaction in the regulation of peripheral opioid-mediated analgesia in inflammation. Front Immunol. 2016;7:293.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
McDowell, T.S. (2019). Peripheral Mechanisms of Pain Transmission and Modulation. In: Abd-Elsayed, A. (eds) Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-99124-5_9
Download citation
DOI: https://doi.org/10.1007/978-3-319-99124-5_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-99123-8
Online ISBN: 978-3-319-99124-5
eBook Packages: MedicineMedicine (R0)