This chapter presents the major types of experimental models of pain in animals and humans by outcome measures and methods of insult, as well as the role of computer models in modern research.
KeywordsExperimental models Animal studies Human studies Computer models
- 1.Mogil JS, Davis KD, Derbyshire SW. The necessity of animal models in pain research. Pain. 2010;151:12–7.Google Scholar
- 2.Gregory NS, Harris AL, Robinson CR, Dougherty PM, Fuchs PN, Sluka KA. An overview of animal models of pain: disease models and outcome measures. J Pain. 2013;14:1255–69.Google Scholar
- 3.Mogil JS. Animal models of pain: progress and challenges. Nat Rev Neurosci. 2009;10:283–94.Google Scholar
- 4.Olesen AE, Andresen T, Staahl C, Drewes AM. Human experimental pain models for assessing the therapeutic efficacy of analgesic drugs. Pharmacol Rev. 2012;64:722–79.Google Scholar
- 5.Fogel GB. Computational intelligence approaches for pattern discovery in biological systems. Brief Bioinform. 2008;9(4):307–16.Google Scholar
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