The dorsal horn of the spinal cord is the first relay in the transmission of painful stimuli from the periphery to higher brain centers. Primary nociceptor terminals enter the dorsal horn and form synapses with projection neurons as well as both excitatory and inhibitory interneurons, primarily in laminae I and II. The dorsal horn also receives input from nuclei in the brainstem and other subcortical structures that facilitate or inhibit nociceptive transmission. All these interactions make the spinal dorsal horn a site of complex integration and modulation of nociceptive input.
KeywordsDorsal horn Marginal layer Substantia gelatinosa Projection neuron Substance P NK1 receptor Interneuron Nociceptor Pain Gate control theory
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