Pain pp 95-100 | Cite as

Common Animal Models in the Study of Pain

  • Temugin BertaEmail author
  • Raquel Tonello


Animal models of pain are indispensable for the discovery of new pathophysiological mechanisms and therapeutic options. Advances have been made in identifying rodent model equivalents of various clinical pain conditions and this review endeavors to describe and discuss the most common ones used in today’s research.


Animal models of pain Acute pain Inflammatory pain Neuropathic pain Functional pain Pain behavior 


  1. 1.
    Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain. 1996;64:493–501.Google Scholar
  2. 2.
    Gregory NS, Harris AL, Robinson CR, Dougherty PM, Fuchs PN, Sluka KA. An overview of animal models of pain: disease models and outcome measures [Internet]. J Pain. 2013;14:1255–69.Google Scholar
  3. 3.
    Rose JD, Woodbury CJ. Animal models of nociception and pain. In: Sourcebook of models for biomedical research. Totowa: Humana Press; 2008. p. 333–9.Google Scholar
  4. 4.
    Jaggi AS, Jain V, Singh N. Animal models of neuropathic pain [Internet]. Fundam Clin Pharmacol. 2011;25:1–28.Google Scholar
  5. 5.
    Mogil JS. Animal models of pain: progress and challenges. Nat Rev Neurosci. 2009;10:283–94.Google Scholar
  6. 6.
    King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, et al. Unmasking the tonic-aversive state in neuropathic pain. Nat Neurosci. 2009;12:1364–6.Google Scholar
  7. 7.
    Anand P, Bley K. Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8 patch [Internet]. Br J Anaesth. 2011;107:490–502.Google Scholar
  8. 8.
    Rivière PJ-M. Peripheral kappa-opioid agonists for visceral pain. Br J Pharmacol. 2004;141:1331–4.Google Scholar
  9. 9.
    Bennett GJ. Animal models of pain. In: Kruger L, editor. Methods in pain research. Boca Raton: CRC Press; 2001. p. 67–91.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of CincinnatiCincinnatiUSA

Personalised recommendations