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Pain pp 49-51 | Cite as

Neurotransmitters Involved in Pain Modulation

  • Thomas S. McDowellEmail author
Chapter

Abstract

Neurotransmitters in the dorsal horn may mediate fast synaptic transmission (e.g., glutamate, GABA), or may be slower modulators of neural activity. The latter include peptides like Substance P acting on NK1 receptors, and opioid peptides like enkephalin acting on opioid receptors. The combination of multiple transmitters and complex neuronal circuits makes nociceptive transmission in the dorsal horn heavily modulated.

Keywords

Dorsal horn Pain Nociception Neurotransmitter Glutamate GABA Glycine Norepinephrine Serotonin Opioid Substance P NK1R G protein-coupled receptor 

References

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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