Central sensitization refers to the amplification of the signaling of neurons within the central nociceptive pathway secondary to increased release of excitatory neurotransmitters, enhanced synaptic sensitivity and decreased inhibition. This clinically manifests as mechanical hypersensitivity, allodynia and hyperalgesia. Presented are the clinical findings and proposed mechanisms of central sensitization.
Central sensitization Neuronal plasticity Hyperalgesia Allodynia
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