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A Network Model Reveals That the Experimentally Observed Switch of the Granule Cell Phenotype During Epilepsy Can Maintain the Pattern Separation Function of the Dentate Gyrus

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Hippocampal Microcircuits

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI))

Abstract

The model is a conductance-based neural network model of the brain circuit thought to be involved in pattern separation during hippocampal memory acquisition: the dentate gyrus (DG). In this chapter we explain the concepts of pattern separation and how it was tested in our model. Our hypothesis is that experimentally constrained homeostatic adaptations of intrinsic neuronal properties can restore the pattern separation ability of the DG network, if it was lost during epileptic excitability (Stegen et al. 2009; Young et al. 2009; Yim et al. 2015).

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Acknowledgments

This work was supported by grants of the Deutsche Forschungsgemeinschaft (DFG) to JW (SFB780/C2, WO1563/1-1). AH was supported by the Bernstein Award Computational Neuroscience (to Ilka Diester).

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Authors and Affiliations

  1. Optophysiology Lab, Department of Biology, University of Freiburg, Freiburg, Germany

    Alexander Hanuschkin

  2. Center for Theoretical and Computational Neuroscience and Department of Neuroscience, The University of Texas at Austin, Austin, TX, USA

    Man Yi Yim

  3. Medizinische Hochschule Brandenburg Theodor Fontane, Neuruppin, Germany

    Jakob Wolfart

  4. Oscar Langendorff Institute of Physiology, University of Rostock, Rostock, Germany

    Jakob Wolfart

Authors
  1. Alexander Hanuschkin
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  2. Man Yi Yim
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  3. Jakob Wolfart
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Correspondence to Jakob Wolfart .

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  1. School of Computer Science, University of Lincoln, Lincoln, UK

    Vassilis Cutsuridis

  2. School of Natural Sciences, Department of Computing Science and Mathematics, University of Stirling, Stirling, UK

    Bruce P. Graham

  3. Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK

    Stuart Cobb

  4. Institute for Integrative Neuroanatomy, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Imre Vida

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Hanuschkin, A., Yim, M.Y., Wolfart, J. (2018). A Network Model Reveals That the Experimentally Observed Switch of the Granule Cell Phenotype During Epilepsy Can Maintain the Pattern Separation Function of the Dentate Gyrus. In: Cutsuridis, V., Graham, B., Cobb, S., Vida, I. (eds) Hippocampal Microcircuits. Springer Series in Computational Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-99103-0_23

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