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Lymphoproliferative Disorders

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Mediastinal Pathology

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Abstract

Primary lymphoproliferative tumors of the mediastinum, similarly to their counterparts in the lymph nodes, have undergone significant changes over the last decade. These changes have been not only in terms of classification but also in terms of new approaches regarding their diagnosis. Needless to say, particularly in the mediastinum, the significant developments in our understanding of these tumors have modified older concepts and terms that may have created confusion in the literature. Terms such as granulomatous thymoma have been correctly reinterpreted as Hodgkin’s lymphoma and in turn have provided significant changes in the treatment and survival of these patients. In this chapter we will focus our discussion in those tumors occurring in the mediastinum. In addition, the chapter will be presented from the practical point of view for the practicing pathologist who may be called upon to interpret these lesions. In cases in which the utility of more advanced studies is needed, specific mention of it will be made. However, the chapter will focus more on the histopathological and immunohistochemical approach to mediastinal lymphoproliferative lesions. In addition, it is important to highlight that the focus will be on primary mediastinal lymphomas and not on the involvement of the mediastinum by lymphoma as a systemic disease. This chapter will discuss non-Hodgkin’s lymphoma (large B-cell lymphoma/primary mediastinal B-cell lymphoma, gray zone lymphoma, anaplastic large cell lymphoma, MALT lymphoma), lymphoblastic lymphoma, Hodgkin’s lymphoma, dendritic cell tumors, plasmacytoma, Castleman’s disease, and extramedullary hematopoiesis (as mediastinal tumor).

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    Neda Kalhor & Cesar Moran

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Kalhor, N., Moran, C. (2019). Lymphoproliferative Disorders. In: Mediastinal Pathology . Springer, Cham. https://doi.org/10.1007/978-3-319-98980-8_13

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