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Mesenchymal Tumors

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Mediastinal Pathology

Abstract

Primary mesenchymal tumors arising in the mediastinal compartment are rare. The occurrence of such tumors is by no means limited to a specific compartment, as these tumors have been described in the anterior and posterior mediastinum. In addition, in terms of the variety of these tumors in the mediastinal compartment, the gamut of soft tissue neoplasms in the mediastinum is similar to that observed in the soft tissues, with some minor differences that are intrinsic to this particular anatomic location. In this chapter, we have divided tumors based on the type of tissue present or the specific differentiation of the neoplasm, as far as our current knowledge permits, and have provided an analysis of these tumors in the mediastinum. This chapter will highlight the following neoplasms: adipose tissue tumors; vascular tumors; smooth and skeletal muscle tumors; fibroblastic, myofibroblastic, and fibrohistiocytic tumors; biphasic (epithelial/mesenchymal) tumors; chondroid and osseous tumors; and other mesenchymal neoplasms. This chapter will be presented from the practical point of view for the practicing pathologist who may be called upon to interpret these tumors. Clinical, pathological, histopathological, immunohistochemical, radiological, gross, molecular features will be discussed, as well as differential diagnoses and staging.

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References

  1. Pachter MR, Lattes R. Mesenchymal tumors of the mediastinum. I. Tumors of fibrous tissue, adipose tissue, smooth muscle, and striated muscle. Cancer. 1963;16:74–94.

    Article  CAS  PubMed  Google Scholar 

  2. Swanson PE. Soft tissue neoplasms of the mediastinum. Semin Diagn Pathol. 1991;8:14–34.

    CAS  PubMed  Google Scholar 

  3. De Bakker MA, Marx A, Mukai K, Strobel P. Mesenchymal tumours of the mediastinum –Part I. Virchows Arch. 2015;467:487–500.

    Article  CAS  Google Scholar 

  4. Lange L. Über ein Lipom des thymus. Zentralbl Allg Pathol. 1916;27:97.

    Google Scholar 

  5. Dew AW, Foot NC. Report of a large thymic tumor successfully removed by operation. J Thorac Surg. 1937;6:648–59.

    Article  Google Scholar 

  6. Hall GFM. A case of thymolipoma. With observations on a possible relationship to intrathoracic lipomata. Br J Surg. 1949;36:321–4.

    Article  CAS  PubMed  Google Scholar 

  7. Toyama T, Mizuno T, Masaoka A, Shibata K, Yamakawa Y, Niwa H, et al. Pathogenesis of thymolipoma: report of three cases. Jpn J Surg. 1995;25:86–8.

    CAS  Google Scholar 

  8. Rieker RJ, Schirmacher P, Schnabel PA, Moser K, Hoffmann H, Dienemann H, et al. Thymolipoma. A report of nine cases, with emphasis on its association with myasthenia gravis. Surg Today. 2010;40:132–6.

    Article  PubMed  Google Scholar 

  9. Damadoglu E, Salturk C, Takir HB, Ertugrul M, Yilmaz A, Atasalihi A, et al. Mediastinal thymolipoma: an analysis of 10 cases. Respirology. 2007;12:924–7.

    Article  PubMed  Google Scholar 

  10. Otto HF, Lachenmayer L, Janzen RW, Janzen RW, Gürtler KF, Fischer K. Thymolipoma in association with myasthenia gravis. Cancer. 1982;50:1623.

    Article  CAS  PubMed  Google Scholar 

  11. Reintgen D, Fetter BF, Roses A, McCarty KS Jr. Thymolipoma in association with myasthenia gravis. Arch Pathol Lab Med. 1978;102:463.

    CAS  PubMed  Google Scholar 

  12. Gunnells JC, Miller E, Jacoby WJ, May RL. Thymolipoma simulating cardiomegaly: opacification of the tumor by cineangiocardiography. Am Heart J. 1963;66:670.

    Article  PubMed  Google Scholar 

  13. Benton C, Gerard P. Thymolipoma in a patient with Graves’ disease. J Thorac Surg. 1966;51:428.

    Article  CAS  Google Scholar 

  14. Boetsch CH, Swoyer GB, Adams A, Walker JH. Lipothymoma. Report of two cases. J Dis Chest. 1966;50:539.

    Article  CAS  Google Scholar 

  15. Levine S, Labiche H, Chandor S. Thymolipoma. Report of a case. 1968;98:875.

    Google Scholar 

  16. Barnes RDS, Gorman PO. Two cases of aplastic anemia associated with tumors of the thymus. J Clin Pathol. 1962;15:264.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Rosado-de-Christenson M, Pugatch RD, Moran CA, Galobardes J. Thymolipoma: Analysis of 27 cases. Radiology. 1994;193:121–6.

    Article  CAS  PubMed  Google Scholar 

  18. Moran CA, Rosado-de-Christenson M, Suster S. Thymolipoma: clinicopathologic review of 33 cases. Mod Pathol. 1995;8:741–4.

    CAS  PubMed  Google Scholar 

  19. Ajaz B, Tran TAN, Truong T, Manoucheri M. Thymolipoma with sebaceous differentiation: a hitherto unreported variant of thymolipoma. Int J Surg Pathol. 2013;21:526–30.

    Article  PubMed  Google Scholar 

  20. Kim YK, Shin N, Park WY, Park DY, Huh GY, Lee CH. Mediastinal thymolipoma with striated myoid cells: report of a peculiar case. Korean J Pathol. 2013;47:596–8.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Iseki M, Tsuda N, Kishikawa M, Shimada O, Hayashi T, Kawahara K, et al. Thymolipoma with striated myoid cells: histological, Immunohistochemical, and ultrastructural study. Am J Surg Pathol. 1990;14:395–8.

    Article  CAS  PubMed  Google Scholar 

  22. Gannon BR, Dexter DF, Petsikas D, Isotalo PA. Mediastinal thymolipoma: a rare occurrence with striated myoid cells. Tumori. 2007;93:198–200.

    Article  PubMed  Google Scholar 

  23. Moran CA, Zeren H, Koss MN. Thymofibrolipoma: a histological variant of thymolipoma. Arch Pathol Lab Med. 1994;118:281–2.

    CAS  PubMed  Google Scholar 

  24. Weissferdt A, Moran CA. Lipomatous tumors of the anterior mediastinum with muscle differentiation: a clinicopathological and Immunohistochemical study of three cases. Vichows Arch. 2014;464:489–93.

    Article  Google Scholar 

  25. Bertrand G, Bidabe MC, George P, Dubin P, Touzard C. Angiomyolipoma of the central mediastinum. An apparently undescribed entity. Ann Chir. 1984;38:679–81.

    CAS  PubMed  Google Scholar 

  26. Candas F, Berber U, Yildizhan A, Yiyit N, Görür R, Ișitmangil T. Anterior mediastinal angiomyolipoma. Ann Thorac Surg. 2013;95:1431–2.

    Article  PubMed  Google Scholar 

  27. Morita K, Shida Y, Shinozaki K, et al. Angiomyolipomas of the mediastinum and lung. J Thorac Imaging. 2012;27:W21–3.

    Article  PubMed  Google Scholar 

  28. Knight CS, Cerfolio RJ, Winokur TS. Angiomyolipoma of the anterior mediastinum. Ann Diagn Pathol. 2008;12:293–5.

    Article  PubMed  Google Scholar 

  29. Watts KA, Watts JR. Incidental discovery of an anterior mediastinal angiomyolipoma. J Thorac Imaging. 2007;22:180–1.

    Article  PubMed  Google Scholar 

  30. Amir AM, Zeebregts CJ, Mulder HJ. Anterior mediastinal presentation of a giant angiomyolipoma. Ann Thorac Surg. 2004;78:2161–3.

    Article  PubMed  Google Scholar 

  31. Fukuzawa J, Shimizu T, Sakai E, Ido A, Fujita Y, Tsuji T, et al. Case report of angiomyolipoma of the posterior upper mediastinum. Nihon Kyobu Shikkan Gakkai Zasshi. 1992;30:464–7.

    CAS  PubMed  Google Scholar 

  32. Downes KA, Goldblum JR, Montgomery EA, Fisher C. Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. Mod Pathol. 2001;14:179–84.

    Article  CAS  PubMed  Google Scholar 

  33. Alaggio R, Coffin CM, Weiss SW, Bridge JA, Issakov J, Oliveira AM, et al. Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age. Am J Surg Pathol. 2009;33:645–58.

    Article  PubMed  Google Scholar 

  34. Chen M, Yang J, Zhu L, Zhou C, Zhao H. Primary intrathoracic liposarcoma: a clinicopathologic study and prognostic analysis of 23 cases. J Cardiothorac Surg. 2014;9:119–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Razzuk MA, Ursckel HC, Race GJ, Kingsley WB, Paulson DL. Liposarcoma of the mediastinum: case report and review of the literature. J Thorac Cardiovasc Surg. 1971;61:819–26.

    Article  CAS  PubMed  Google Scholar 

  36. Schweistzer DL, Aguam AS. Primary liposarcoma of the mediastinum: report of a case and review of the literature. J Thorac Cardiovasc Surg. 1977;74:83–97.

    Article  Google Scholar 

  37. Standerfer RJ, Armistead SH, Paneth M. Liposarcoma of the mediastinum: report of a two cases and review of the literature. Thorax. 1981;36:693–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Havlicek F, Rosai J. A sarcoma of the thymic stroma with features of liposarcoma. Am J Clin Pathol. 1984;82:217–24.

    Article  CAS  PubMed  Google Scholar 

  39. Dogan R, Kara M, Yazicioglu A, Onder S. Giant atypical lipomatous tumor of the mediastinum. Tuberkuloz ve Toraks Dergisi. 2008;56:100–3.

    Google Scholar 

  40. Klimstra DS, Moran CA, Periono G, Koss MN, Rosai J. Liposarcoma of the anterior mediastinum and thymus: a clinicopathologic study of 28 cases. Am J Surg Pathol. 1995;19:782–91.

    Article  CAS  PubMed  Google Scholar 

  41. Hahn HP, Fletcher CDM. Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases. Am J Surg Pathol. 2007;31:1868–74.

    Article  PubMed  Google Scholar 

  42. Boland JM, Colby TV, Folper AL. Liposarcomas of the mediastinum and thorax: a clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features. Am J Surg Pathol. 2012;36:1395–403.

    Article  PubMed  Google Scholar 

  43. Ortega P, Suster D, Falconieri G, Zambrano E, Moran CA, Morrison C, et al. Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases. Mod Pathol. 2015;28:721–31.

    Article  CAS  PubMed  Google Scholar 

  44. Evans HL, Khurana KK, Kemp BL, Ayala AG. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol. 1994;18:1150–7.

    Article  CAS  PubMed  Google Scholar 

  45. Evan HL. Smooth muscle in atypical lipomatous tumors: a report of three cases. Am J Surg Pathol. 1990;14:714–8.

    Article  Google Scholar 

  46. Suster S, Wong TY, Moran CA. Sarcomas with combined features of liposarcoma and leiomyosarcoma. Am J Surg Pathol. 1993;17:905–11.

    Article  CAS  PubMed  Google Scholar 

  47. Tallini G, Erlandson RA, Brennan MF, Woodruff JM. Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. Am J Surg Pathol. 1993;17:546–56.

    Article  CAS  PubMed  Google Scholar 

  48. Shanks JH, Banerjee SS, Eyden BP. Focal rhabdomyosarcomatous differentiation in primary liposarcoma. J Clin Pathol. 1996;49:770–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Zamecnik M, Michal M, Sulc M. Atypical lipomatous tumors with smooth muscle differentiation: report of two cases. Pathology. 1999;31:425–7.

    Article  CAS  PubMed  Google Scholar 

  50. Gomez-Roman JJ, Val-Bernal JF. Lipoleiomyosarcoma of the mediastinum. Pathology. 1997;29:428–30.

    Article  CAS  PubMed  Google Scholar 

  51. Folpe AL, Weiss SW. Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation). Am J Surg Pathol. 2002;26:742–9.

    Article  PubMed  Google Scholar 

  52. Weissferdt A, Moran CA. Lipomatous tumors of the anterior mediastinum with smooth muscle differentiation: a clinicopathological and Immunohistochemical study of three cases. Virchows Arch. 2014;464:489–93.

    Article  PubMed  Google Scholar 

  53. Miettinen M, Enzinger FM. Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. Mod Pathol. 1999;12:722–8.

    CAS  PubMed  Google Scholar 

  54. Huang HY, Antonescu CR. Epithelioid variant of pleomorphic liposarcoma: a comparative Immunohistochemical and ultrastructural analysis of six cases with emphasis on overlapping features with epithelial malignancies. Ultrastruct Pathol. 2002;26:299–300.

    Article  PubMed  Google Scholar 

  55. Wang L, Ren W, Zhou X, Sheng W, Wang J. Pleomorphic liposarcoma: a clinicopathological, Immunohistochemical and molecular cytogenetics study of 32 additional cases. Pathol Int. 2013;63:523–31.

    Article  CAS  PubMed  Google Scholar 

  56. Doyle LA, Tao D, Marino-Enriquez A. STAT6 is amplified in a subset of dedifferentiated liposarcoma. Mod Pathol. 2014;27:1231–7.

    Article  CAS  PubMed  Google Scholar 

  57. Seybold WD, McDonald JR, Clagett OT, Harrington SW. Metastatic tumors of vascular origin. J Thorac Surg. 1949;18:503–7.

    Article  CAS  PubMed  Google Scholar 

  58. Pachter MR, Lattes R. Mesenchymal tumors of the mediastinum. II Tumors of blood vascular origin. Cancer. 1963;16:95–107.

    Article  Google Scholar 

  59. Pachter MR, Lattes R. Mesenchymal tumors of the mediastinum. III Tumors of lymph vascular origin. 1963;16:108–17.

    Google Scholar 

  60. Hall ER, Blades B. Lymphangioma of the mediastinum. Dis Chest. 1957;XXXII:1–7.

    Google Scholar 

  61. Dische MR. Mediastinal lymphangioma with chylothorax in infancy. Report of a case and review of the literature. Am J Clin Pathol. 1968;49:392–7.

    Article  CAS  PubMed  Google Scholar 

  62. Sanes S, Macmanus JE, Scatchard N. Cystic lymphangioma of the mediastinum. J Thorac Surg. 1944:253–8.

    Google Scholar 

  63. Shennan T. Histologically non-malignant angioma with numerous metastases. J Pathol. 1914;19:139–54.

    Article  Google Scholar 

  64. Davis JM, Mark GJ, Greene R. Benign blood vascular tumors of the mediastinum. Report of four cases and review of the literature. Radioloagy. 1978;126:581–7.

    CAS  Google Scholar 

  65. Leibovici D, Oner V. Hemangioma of the posterior mediastinum: review of the literature and report of a case. Am Rev Respir Dis. 1962;86:415–9.

    CAS  PubMed  Google Scholar 

  66. Gindhart TD, Tucker WY, Choy SH. Cavernous hemangioma of the superior mediastinum: Report of a case with electron microscopy and computerized tomography. Am J Surg Pathol. 1979;3:353–61.

    Article  CAS  PubMed  Google Scholar 

  67. Coher AJ, Sbaschnig RJ, Hochholzer L, Lough FC, Albus RA. Mediastinal Hemangiomas. Ann Thorac Surg. 1987;43:656–9.

    Article  Google Scholar 

  68. John I, Folpe AL. Anastomosing hemangiomas arising in unusual locations: a clinicopathologic study of 17 soft tissue cases showing a predilection for the paraspinal region. Am J Surg Pathol. 2016;40:1084–9.

    Article  PubMed  Google Scholar 

  69. Moran CA, Suster S. Mediastinal hemangiomas: a study of 18 cases with emphasis on the spectrum of morphological features. Hum Pathol. 1995;26:416–21.

    Article  CAS  PubMed  Google Scholar 

  70. McAdams HP, Rosado-de-Christenson ML, Moran CA. Mediastinal hemangioma: radiographic and CT features in 14 patients. 1994;193(2):399–402.

    Google Scholar 

  71. Deyrup AT, Tighiouart M, Montag AG, Weiss SW. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol. 2008;32:924–7.

    Article  PubMed  Google Scholar 

  72. Anderson T, Zhang L, Hameed M, Rusch V, Travis WD, Antonescu CR. Thoracic epithelioid malignant vascular tumors: a clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions. Am J Surg Pathol. 2015;39:132–9.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Lamovec J, Sobel HJ, Zidar A, Jerman J. Epithelioid hemangioendothelioma of the anterior mediastinum with osteoclast-giant cells. Light microscopic, Immunohistochemical and electron microscopy study. Am J Clin Pathol. 1990;93:813–7.

    Article  CAS  PubMed  Google Scholar 

  74. Toursarkissian B, O’Connor WN, Dillon ML. Mediastinal epithelioid hemangioendothelioma. Ann Thorac Surg. 1990;49:680–5.

    Article  CAS  PubMed  Google Scholar 

  75. Weidner N. Atypical tumor of the mediastinum: epithelioid hemangioendothelioma containing metaplastic bone and osteoclast like giant cells. Ultrastruct Pathol. 1991;15:481–8.

    Article  CAS  PubMed  Google Scholar 

  76. Kumar A, Lopez YK, Arrossi AV, et al. Mediastinal epithelioid hemangioendothelioma. Am J Respir Crit Care Med. 2016;193:e7–8.

    Article  PubMed  Google Scholar 

  77. Li XM, Lin XY, Xu HT, Yu J-H, Wang L, Fan C-F, et al. Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. Diagn Pathol. 2013;8:103.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Suster S, Moran CA, Koss MN. Epithelioid hemangioendothelioma of the anterior mediastinum: Clinicopathologic, Immunohistochemical, and ultrastructural analysis of 12 cases. Am J Surg Pathol. 1994;18:871–81.

    Article  CAS  PubMed  Google Scholar 

  79. Weinreb I, Cunningham KS, Perez-Ordonez B, Hwang DM. CD10 is expressed in most epithelioid hemangioendotheliomas: a potential diagnostic pitfall. Arch Pathol Lab Med. 2009;133:1965–8.

    Article  PubMed  Google Scholar 

  80. Kardamakis D, Bouboulis N, Ravazoula P, Dimopoulos P, Dougenis D. Primary hemangiosarcoma of the mediastinum. Lung Cancer. 1996;16:81–6.

    Article  CAS  PubMed  Google Scholar 

  81. Gibbs AR, Johnson NF, Giddings JC, Powell DE, Jasani B. Primary angiosarcoma of the mediastinum: light and electron microscopic demonstration of factor VIII –related antigen in neoplastic cells. Hum Pathol. 1984;15:687–91.

    Article  CAS  PubMed  Google Scholar 

  82. Chen TJ, Chiou CC, Chen CH, Kuo TT, Hong HS. Metastasis of mediastinal epithelioid angiosarcoma to the finger. Am J Clin Dermatol. 2008;9:181–3.

    Article  PubMed  Google Scholar 

  83. Deyrup AT, Miettinen M, North PE, Khoury JD, Tighiouart M, Spunt SL, et al. Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol. 2009;33:264–9.

    Article  PubMed  Google Scholar 

  84. Meis-Kindblom JM, Kindblom LG. Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg Pathol. 1998;22:683–97.

    Article  CAS  PubMed  Google Scholar 

  85. Weissferdt A, Kalhor N, Suster S, Moran CA. Primary angiosarcomas of the anterior mediastinum: a clinicopathologic and immunohistochemical study of 9 cases. Hum Pathol. 2010;41:1711–7.

    Article  CAS  PubMed  Google Scholar 

  86. Domingue-Malagon H, Cano-Valdez AM, Moran CA, Suster S. Germ cell tumors with sarcomatous components: a clinicopathologic and Immunohistochemical study of 46 cases. Am J Surg Pathol. 2007;31:1356–62.

    Article  Google Scholar 

  87. Luina Contreras A, Punar M, Tamboli P, Tu SM, Pisters L, Moran C, et al. Mediastinal germ cell tumors with angiosarcomatous component: a report of 12 cases. Hum Pathol. 2010;41:832–7.

    Article  Google Scholar 

  88. Sunderrajan EV, Luger AM, Rosenholtz MJ, Maltby JD. Leiomyosarcoma in the mediastinum presenting as superior vena cava syndrome. Cancer. 1984;53:2553–6.

    Article  CAS  PubMed  Google Scholar 

  89. Weiss KS, Zidar BL, Wang S, Magovern GJ Sr, Raju RN, Lupetin AR, et al. Radiation-induced leiomyosarcoma of the great vessels presenting as superior vena cava syndrome. Cancer. 1987;60:1238–42.

    Article  CAS  PubMed  Google Scholar 

  90. Gupta S, Jindal SK, Vashist R, Singh H, Malik SK. Leiomyosarcoma of the mediastinum. Eur J Respir Dis. 1983;64:69–71.

    CAS  PubMed  Google Scholar 

  91. Herlitzka AJ, Gale JW. Tumors and cyst of the mediastinum. Arch Surg. 1958;76:697–703.

    Article  CAS  Google Scholar 

  92. Lincoln JCR. Leiomyosarcoma of the anterior mediastinum. Thorax. 1965;20:362–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Rasaretnam R, Panabokke RG. Leiomyosarcoma of the mediastinum. Br J Dis Chest. 1975;69:63–9.

    Article  CAS  PubMed  Google Scholar 

  94. Matsuoka H, Nishio W, Sakamoto T, Harada H, Sashikata T, Tsubota N. Mediastinal angioleiomyoma. Ann Thorac Surg. 2002;73:1653–4.

    Article  PubMed  Google Scholar 

  95. Ouadnouni Y, Achir A, Bekarsabein S, Bouchikh M, Smahi M, Msougar Y, et al. Primary mediastinal leiomyoma: a case report. Cases J. 2009;2:8555.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Baldo X, Sured C, Gimferrer JM, Belda J. Primary mediastinal leiomyoma: an angiographic study and embolization of the feeding vessels to improve the surgical approach. Eur J Cardiothorac Surg. 1997;11:574–6.

    Article  CAS  PubMed  Google Scholar 

  97. Vrtik M, Larbalestier RI, Cameron D, et al. Mediastinal angioleiomyoma. Ann Thorac Surg. 2002;73:1653–4.

    Article  Google Scholar 

  98. Moran CA, Suster S, Perino G, et al. Malignant smooth muscle tumors presenting as mediastinal soft tissue masses. Cancer. 1994;74:2251–60.

    Article  CAS  PubMed  Google Scholar 

  99. Fox JP, Hospers CA. Solid teratoid tumors of the anterior mediastinum. Am J Cancer. 1936;28:273–90.

    Google Scholar 

  100. Horn RC, Enterline HT. Rhabdomyosarcoma: a clinicopathologic study and classification of 39 cases. Cancer. 1958;11:181–99.

    Article  PubMed  Google Scholar 

  101. Patton RB, Horn RC. Rhabdomyosarcoma: clinical and pathological features and comparison with human fetal and embryonal skeletal muscle. Surgery. 1962;52:572–84.

    CAS  PubMed  Google Scholar 

  102. Crist WM, Raney RB, Newton W, Lawrence W, Tefft M, Foulkes MA. Intrathoracic soft tissue sarcomas in children. Cancer. 1982;50:598–604.

    Article  CAS  PubMed  Google Scholar 

  103. Suster S, Moran CA, Koss MN. Rhabdomyosarcomas of the anterior mediastinum: report of four cases unassociated with germ cell, teratomatous, or thymic carcinomatous components. Hum Pathol. 1994;25:349–56.

    Article  CAS  PubMed  Google Scholar 

  104. Allagio R, Zhang L, Sung YS, Huang SC, Chen CL, Bisogno G, et al. A molecular study of pediatric spindle and sclerosing rhabdomyosarcoma: identification of novel and recurrent VGLL2-related fusions in infantile cases. Am J Surg Pathol. 2016;40:224–35.

    Article  Google Scholar 

  105. Owosho AA, Huang SCm Chen S, Kashikar S, Estilo CL, Wolden SL, et al. A clinicopathologic study of head and neck rhabdomyosarcomas showing FOXO1 fusion-positive alveolar and MYOD1-mutant sclerosing are associated with unfavorable outcome. Oral Oncol. 2016;61:89–7.

    Article  PubMed Central  Google Scholar 

  106. Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, et al. Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma. Nat Commun. 2015;6:7557.

    Article  PubMed  Google Scholar 

  107. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol. 1989;13:640–58.

    Article  CAS  PubMed  Google Scholar 

  108. Moran CA, Suster S, Koss MN. The spectrum of histologic growth pattern in benign and malignant fibrous tumors of the pleura. Semin Diagn Pathol. 1992;9:169–80.

    CAS  PubMed  Google Scholar 

  109. Witkin GB, Rosai J. Solitary fibrous tumor of the mediastinum: a report of 14 cases. Am J Surg Pathol. 1989;13:547–57.

    Article  CAS  PubMed  Google Scholar 

  110. Suehisa H, Yamashita M, Komori E, Sawada S, Teramoto N. Solitary fibrous tumor of the mediastinum. Gen Thorac Cardiovasc Surg. 2010;58:205–8.

    Article  PubMed  Google Scholar 

  111. De Raet J, Sacre R, Hoorens A, Fletcher C, Lamote J. Malignant giant solitary fibrous tumor of the mediastinum. J Thorac Oncol. 2008;3:1068–70.

    Article  PubMed  Google Scholar 

  112. Chnaris A, Barbetakis N, Efstathiou A, Fessatidis I. Primary mediastinal hemangiopericytoma Case Report. World J Surg Oncol. 2006;4:23–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and Immunohistochemical study of 84 cases. Am J Surg Pathol. 1995;19:859–72.

    Article  CAS  PubMed  Google Scholar 

  114. Makimoto Y, Nabeshima K, Iwasaki H, Ishiguro A, Miyoshi T, Shiraishi T, et al. Inflammatory myofibroblastic tumor of the posterior mediastinum: an older adult case with anaplastic lymphoma kinase abnormalities determined using immunohistochemistry and fluorescence in situ hybridization. Virchows Arch. 2005;446:451–5.

    Article  PubMed  Google Scholar 

  115. Chen CH, Lin RL, Liu HC, Chen CH, Hung TT, Huang WC. Inflammatory myofibroblastic tumor mimicking anterior mediastinal malignancy. Ann Thorac Surg. 2008;86:1362–4.

    Article  PubMed  Google Scholar 

  116. Chen G, Folpe AL, Colby TV, Sittampalam K, Patey M, Chen MG, et al. Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology. Mod Pathol. 2011;24:1560–70.

    Article  CAS  PubMed  Google Scholar 

  117. Asakura S, Tezuka N, Inoue S, Kihara N, Fujino S. Angiomatoid fibrous histiocytoma in mediastinum. Ann Thorac Surg. 2001;72:283–5.

    Article  CAS  PubMed  Google Scholar 

  118. Seethala R, Moran CA. Angiomatoid fibrous histiocytoma of the mediastinum. Pathol Case Rev. 2006;11(5):222–5.

    Article  Google Scholar 

  119. Fu K, Suster S, Moran CA. Primary mediastinal giant cell tumors: a clinicopathologic and Immunohistochemical study of two cases. Ann Diagn Pathol. 2002;6:100–5.

    Article  PubMed  Google Scholar 

  120. Imai K, Saito H, Minamiya Y, Hashimoto M, Kimura Y, Ogawa J. Malignant fibrous histiocytoma originating from thymus. Gen Thorac Cardiovasc Surg. 2008;56:606–9.

    Article  PubMed  Google Scholar 

  121. Nishida T, Nishiyama N, Kawata Y, Yamamoto T, Inoue K, Suehiro S. Mediastinal malignant fibrous histiocytoma developing from a foreign body granuloma. Jpn J Thorac Cardiovasc Surg. 2005;53:583–6.

    Article  PubMed  Google Scholar 

  122. Witkin GB, Miettinen M, Rosai J. A biphasic tumor of the mediastinum with features of synovial sarcoma: report of four cases. Am J Surg Pathol. 1989;13:490–9.

    Article  CAS  PubMed  Google Scholar 

  123. Suster S, Moran CA. Primary synovial sarcoma of the mediastinum: a clinicopathologic, Immunohistochemical, and ultrastructural study of 15 cases. Am J Surg Pathol. 2005;29:569–78.

    Article  PubMed  Google Scholar 

  124. Ershad R, Rahim M, Davari H. Primary synovial sarcoma: a rare case report. Int J Surg Case Rep. 2016;27:169–71.

    Article  Google Scholar 

  125. Lan T, Chen H, Xion B, Zhou T, Peng R, Chen M, et al. Primary pleuropulmonary and mediastinal synovial sarcoma: a clinicopathologic and molecular study of 26 genetically confirmed cases in the largest institution of southwest China. Diagn Pathol. 2016;11:62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  126. Kara HV, Javidfar J, D’Amico TA. Surgical excision of mediastinal synovial sarcoma with limited response to chemotherapy. Ann Thorac Surg. 2014;98:69–70.

    Article  Google Scholar 

  127. Trupiano JK, Rice TW, Herzog K, Barr FG, Shipley J, Fisher C, et al. Mediastinal synovial sarcoma: report of two cases with molecular genetic analysis. Ann Thorac Surg. 2002;73:628–30.

    Article  PubMed  Google Scholar 

  128. Snover DC, Levine GD, Rosai J. Thymic carcinoma. Five distinct histological variants. Am J Surg Pathol. 1982;6:451–70.

    Article  CAS  PubMed  Google Scholar 

  129. Vilela DS, Valien JSS, Moran MAG, Garcia FI, Velasco JRR, et al. Thymic carcinosarcoma associated with a spindle cell thymoma. Histopathology. 1992;21:263–8.

    Article  Google Scholar 

  130. Okudela K, Nakamura N, Sano J, Ito T, Kitamura H. Thymic carcinosarcoma consisting of squamous cell carcinoma and embryonal rhabdomyosarcomatous component. Pathol Res Pract. 2001;197:205–10.

    Article  CAS  PubMed  Google Scholar 

  131. Moran CA, Koss MN. Rhabdomyomatous thymoma. Am J Surg Pathol. 1993;17:633–6.

    Article  CAS  PubMed  Google Scholar 

  132. De Queiroga EM, Chikota H, Bacchi CE, Moran CA, Suster S. Rhabdomyomatous carcinoma of the thymus. Am J Surg Pathol. 2004;28:1245–50.

    Article  PubMed  Google Scholar 

  133. Chetty R. Extraskeletal mesenchymal chondrosarcoma of the mediastinum. Histopathology. 1990;17:261–78.

    Article  CAS  PubMed  Google Scholar 

  134. Montresor E, Abrescia E, Bertrand C, Piazzola E, Girardi C, Iacono C, et al. Mediastinal chondrosarcoma: Case report. Acta Chir Scand. 1990;156:733–6.

    CAS  PubMed  Google Scholar 

  135. Pescarmona E, Rendina EA, Venuta F, Pisacane A, Baroni CD. Myxoid chondrosarcoma of the mediastinum. Appl Pathol. 1989;7:318–21.

    CAS  PubMed  Google Scholar 

  136. Phillips GWL, Choong M. Case Report: chondrosarcoma presenting as an anterior mediastinal mass. Clin Radiol. 1991;43:63–4.

    Article  CAS  PubMed  Google Scholar 

  137. Widdowson DJ, Lewis-Jones HG. A large soft tissue chordoma arising in the posterior mediastinum. Clin Radiol. 1988;39:33–335.

    Article  Google Scholar 

  138. Angulo-Hervias E, Lacasa CL, Crespo-Rodriguez AM, Romeo DY. Chondrosarcoma mesenquimal primario en el mediastino. Radiologia. 2007;49:358–61.

    Article  CAS  PubMed  Google Scholar 

  139. Suster S, Moran CA. Malignant cartilaginous tumors of the mediastinum: clinicopathological study of six cases presenting as extraskeletal soft tissue masses. Hum Pathol. 1997;28:588–94.

    Article  CAS  PubMed  Google Scholar 

  140. Christopherson WM, Foote FW, Stewart FW. Alveolar soft part sarcomas: structurally characteristic tumors of uncertain histogenesis. Cancer. 1952;5:100–11.

    Article  CAS  PubMed  Google Scholar 

  141. Kameda Y, Nishii T, Tsuboi M, Arai H, Inui K, Kaneko T, et al. Alveolar soft part sarcoma of the mediastinum: a case report. SAGE Open Med Case Rep. 2017;23(5):2050313.

    Google Scholar 

  142. Flieder D, Moran CA, Suster S. Primary alveolar soft part sarcoma of the mediastinum: a clinicopathological and Immunohistochemical study of two cases. Histopathology. 1997;31:469–73.

    Article  CAS  PubMed  Google Scholar 

  143. Crowe GG, Muldoon PB. Thoracic chordoma. Thorax. 1951;6:403–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  144. Geukdjiian SA. Chordoma of the dorsal spine. Can J Surg. 1958;2:106–8.

    Google Scholar 

  145. Caputo PJ. Chordoma of the thoracic spine. Case report of a rare entity. Northwest Med. 1959;58:553–4.

    CAS  PubMed  Google Scholar 

  146. Clemons RL, Blank RH, Hutchenson JB, Ruffolo EH. Chordoma presenting as posterior mediastinal mass. J Thorac Cardiovasc Surg. 1972;63:922–4.

    Article  CAS  PubMed  Google Scholar 

  147. Castellano GC, Johnston HW. Intrathoracic chordoma presenting as a posterior mediastinal tumor. Case Report. South Med J. 1975;68:109–12.

    Article  CAS  PubMed  Google Scholar 

  148. Maesen F, Baur C, Lamers J, Versteege C, Willighagen R. Chordoma of the thorax. Eur J Respir Dis. 1986;68:68–72.

    CAS  PubMed  Google Scholar 

  149. Ahrendt MN, Wesselhoeft CW. Chordoma presenting as a posterior mediastinal mass in a pediatric patient. J Pediatr Surg. 1992;27:1515–8.

    Article  CAS  PubMed  Google Scholar 

  150. Matsubayashi J, Sato E, Nomura M, Kakihana M, Uchida O, Saji H, et al. A case of paravertebral mediastinal chordoma without bone destruction. Skelet Radiol. 2012;41:1641–4.

    Article  Google Scholar 

  151. Suster S, Moran CA. Chordomas of the mediastinum: clinicopathologic, Immunohistochemical, and ultrastructural study of six cases presenting as posterior mediastinal masses. Hum Pathol. 1995;26:1354–62.

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Neda Kalhor & Cesar Moran

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Kalhor, N., Moran, C. (2019). Mesenchymal Tumors. In: Mediastinal Pathology . Springer, Cham. https://doi.org/10.1007/978-3-319-98980-8_12

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