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The Radiopharmaceutical Chemistry of the Radioisotopes of Iodine

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Abstract

Radioisotopes of iodine have been incorporated into a wide variety of radiopharmaceuticals ranging from small, low molecular weight compounds to large molecules like antibodies. Because of the routine availability of radioisotopes of iodine with different nuclear decay properties, radioiodination is an attractive strategy because the same chemistry can be utilized for both radionuclide imaging and targeted radiotherapy. Over the years, various methods have been developed for the synthesis of radioiodinated compounds. This chapter gives an overview of these methods as well as their potential advantages and disadvantages. Some useful tips and tactics for the radioiodination chemistry are provided. Important milestones in radioiodination chemistry are summarized and some thoughts about the future of radioiodination as a radiopharmaceutical chemistry strategy are provided.

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Authors and Affiliations

  1. Department of Radiology, Duke University Medical Center, Durham, NC, USA

    Ganesan Vaidyanathan

  2. Departments of Radiology, Radiation Oncology, Pathology, and Biomedical Engineering, Duke University Medical Center, Durham, NC, USA

    Michael R. Zalutsky

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Correspondence to Ganesan Vaidyanathan .

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  1. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jason S. Lewis

  2. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

    Albert D. Windhorst

  3. Department of Chemistry, Hunter College, City University of New York, New York, NY, USA

    Brian M. Zeglis

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Vaidyanathan, G., Zalutsky, M.R. (2019). The Radiopharmaceutical Chemistry of the Radioisotopes of Iodine. In: Lewis, J., Windhorst, A., Zeglis, B. (eds) Radiopharmaceutical Chemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-98947-1_22

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  • DOI: https://doi.org/10.1007/978-3-319-98947-1_22

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