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Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Rectal Cancer

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Comprehensive Rectal Cancer Care

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Abstract

The peritoneum is a common site of metastases from colorectal cancer. The treatment of peritoneal metastases has evolved from palliative care only to a potentially curative approach. Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has slowly emerged as an effective locoregional treatment for peritoneal metastases from a variety of malignancies, including colorectal cancer. Most studies combine colon and rectal cancer today as one malignancy: “colorectal cancer”. In this respect, the majority of studies evaluating CRS plus HIPEC include only about 10–15% of patients with rectal cancer so that data concerning advanced peritoneal presentations of rectal cancer treated in this manner need to be viewed with caution. The purpose of this chapter is to review the incidence, treatment and outcomes of peritoneal metastases from colorectal cancer and when relevant from rectal cancer specifically.

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Abbreviations

5-FU:

5-fluorouracil

CC:

Completeness of cytoreduction

CRS:

Cytoreductive surgery

FOLFOX:

Fluorouracil, leucovorin, and oxaliplatin

HIPEC:

Hyperthermic intraperitoneal chemotherapy

LV:

Leucovorin

PCI:

Peritoneal Cancer Index

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Authors and Affiliations

  1. Division of Surgical Oncology, University of Minnesota, Minneapolis, MN, USA

    Todd M. Tuttle

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  1. Todd M. Tuttle
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Correspondence to Todd M. Tuttle .

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Editors and Affiliations

  1. University of California, Los Angeles, Los Angeles, CA, USA

    Mary Kwaan

  2. University of Melbourne, Victoria, VIC, Australia

    Andrew Zbar

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Tuttle, T.M. (2019). Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Rectal Cancer. In: Kwaan, M., Zbar, A. (eds) Comprehensive Rectal Cancer Care. Springer, Cham. https://doi.org/10.1007/978-3-319-98902-0_26

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  • DOI: https://doi.org/10.1007/978-3-319-98902-0_26

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-98901-3

  • Online ISBN: 978-3-319-98902-0

  • eBook Packages: MedicineMedicine (R0)

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