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Peracetic Acid

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Antiseptic Stewardship

Abstract

Peracetic acid has bactericidal activity at 1.6% in 3–5 min, yeasticidal activity at 0.25% in 1 min, and mycobactericidal activity at 0.35% in 5 min. Some food-associated fungi or ascospores, however, are resistant. High MIC values indicating resistance to peracetic acid have so far not been reported but tolerant isolates of E. coli, L. monocytogenes and Salmonella spp. have been described after exposure to nalidixic acid or terpenes. An epidemiological cut-off value to determine acquired resistance has not been proposed yet. No specific resistance mechanisms are currently known for peracetic acid in medically relevant micro-organisms. No cross-tolerance to antibiotics has been reported but peracetic acid can transform different beta-lactam antibiotics in wastewater and help to reduce selection pressure. Low-level exposure does not change the susceptibility of S. enterica and L. monocytogenes but of E. coli. Virulence genes may be induced (S. aureus) or reduced (L. monocytogenes). S. Typhimurium survivors of low-level exposure may be viable but not culturable. Peracetic acid inhibits or even prevents biofilm formation. Biofilm fixation by peracetic acid is between 0 and 54% and depends on the formulation. Biofilm removal is mostly poor (0–63%) and also depends on the formulation.

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  1. Institute of Hygiene and Environmental Medicine, University of Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany

    Günter Kampf

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Kampf, G. (2018). Peracetic Acid. In: Antiseptic Stewardship. Springer, Cham. https://doi.org/10.1007/978-3-319-98785-9_5

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