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Diagnosis of Endometrial Biopsies and Curettings pp 75–119Cite as

Gestational Trophoblastic Disease

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Abstract

The World Health Organization (WHO) classification of gestational trophoblastic disease (GTD) includes disorders of placental development (hydatidiform mole) and neoplasms of the trophoblast (choriocarcinoma, placental site trophoblastic tumor [PSTT], and epithelioid trophoblastic tumor [ETT]). Nonneoplastic lesions include the exaggerated placental site and placental site nodules and plaques. A common feature of all trophoblastic lesions is that they produce human chorionic gonadotropin (hCG), which serves as a clinical marker for the presence of persistent or progressive trophoblastic disease. Because these lesions, especially postmolar trophoblastic disease, are often treated in the absence of a histologic diagnosis, they may be clinically classified as GTD without designation of the morphologic subtype. Nonetheless, identification and separation of the different pathologic forms of the disease are important, as they have different clinical presentations and behavior.

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Authors and Affiliations

  1. Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA

    Tricia A. Murdock, Emanuela F. T. Veras & Robert J. Kurman

  2. Department of Pathology and Laboratory Medicine, State University of New York Upstate Medical University, Syracuse, NY, USA

    Michael T. Mazur

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Murdock, T.A., Veras, E.F.T., Kurman, R.J., Mazur, M.T. (2019). Gestational Trophoblastic Disease. In: Diagnosis of Endometrial Biopsies and Curettings. Springer, Cham. https://doi.org/10.1007/978-3-319-98608-1_4

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