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Gouty Inflammation

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Textbook of Autoinflammation

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Abstract

Inflammation and hyperuricemia drive the gout cascade. Understanding of the role of inflammation, including involvement of the innate immune system, helps to improve the diagnosis and therapeutic course of the disease. Treatment of acute and chronic gouty inflammation is of utmost importance in preventing long-term disability. In this chapter, we discuss the clinical presentation of gout and its diagnosis, immunopathogenesis, and treatment. The anti-inflammatory therapies used to combat gouty inflammation are highlighted.

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Abbreviations

ACP:

American College of Physicians

ACR:

American College of Rheumatology

ACTH:

Adrenocorticotropic hormone

DAMP:

Damage-associated molecular patterns

DECT:

Dual-energy computed tomography

EULAR:

European League Against Rheumatism

FDA:

Food and Drug Administration

IL:

Interleukin

MSU:

Monosodium urate

MTP:

Metatarsophalangeal

NLRP3:

NACHT, LRR and PYD domains-containing protein 3

NSAID:

Non-steroidal anti-inflammatory drugs

SU:

Serum urate

TA:

Triamcinolone acetonide

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

URL:

Urate lowering therapy

US:

Ultrasound

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Author information

Authors and Affiliations

  1. Division of Rheumatology, Department of Medicine, Rutgers Robert Wood Johnson Gout Center, Rutgers Biomedical and Health Sciences Brunswick, New Brunswick, NJ, USA

    Naomi Schlesinger

  2. Department of Medicine, Rutgers—Robert Wood Johnson Medical School, New Brunswick, NJ, USA

    Johnson C. Kay

Authors
  1. Naomi Schlesinger
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  2. Johnson C. Kay
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Corresponding author

Correspondence to Naomi Schlesinger .

Editor information

Editors and Affiliations

  1. Pediatric Rheumatology Unit, Shaare Zedek Medical Center and Hebrew University, Jerusalem, Israel

    Philip J. Hashkes

  2. Department Paediatrics, Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada

    Ronald M. Laxer

  3. Department of Internal Medicine, Radboudumc Expertisecenter for Immunodeficiency and Autoinflammation, Radboud University Medical Center, Nijmegen, The Netherlands

    Anna Simon

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Schlesinger, N., Kay, J.C. (2019). Gouty Inflammation. In: Hashkes, P., Laxer, R., Simon, A. (eds) Textbook of Autoinflammation. Springer, Cham. https://doi.org/10.1007/978-3-319-98605-0_34

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  • DOI: https://doi.org/10.1007/978-3-319-98605-0_34

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-98604-3

  • Online ISBN: 978-3-319-98605-0

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