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Biology of Bone Grafting

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Acetabular Revision Surgery in Major Bone Defects

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Abstract

Allograft bone continues to play an important role in revision hip arthroplasty. A basic understanding of allograft biology and immunology is important in order to increase the success of allografting. The role of immunology in bone transplantation has been known for a long time, but it is now apparent that the bone remodeling system and immune system interact to affect the clinical success of bone transplantation. Neither of the two systems nor their interaction are completely understood. Meanwhile, allografting can still be used with success if one understands the role of allograft biology, immunology, and the important part the host environment have in bone transplantation. Bone extenders and enhancers, such as bioceramics, Demineralised bone matrix, and mesenchymal stem cells mixed with bone allograft have been assessed in acetabular revision surgery with promising results.

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Authors and Affiliations

  1. Orthopaedic Surgery Department, Hospital Universitario La Paz-IdiPaz, Madrid, Spain

    Eduardo García-Rey & Enrique Gómez-Barrena

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  1. Eduardo García-Rey
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  2. Enrique Gómez-Barrena
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Editors and Affiliations

  1. Orthopaedic Surgery Department, Hospital Universitario La Paz-IdiPaz, Madrid, Spain

    Eduardo García-Rey

  2. Orthopaedic Surgery Department, Hospital Universitario La Paz-IdiPaz, Madrid, Spain

    Eduardo García-Cimbrelo

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García-Rey, E., Gómez-Barrena, E. (2019). Biology of Bone Grafting. In: García-Rey, E., García-Cimbrelo, E. (eds) Acetabular Revision Surgery in Major Bone Defects. Springer, Cham. https://doi.org/10.1007/978-3-319-98596-1_4

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  • DOI: https://doi.org/10.1007/978-3-319-98596-1_4

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