Management of Squamous Cell Carcinoma of the Oropharynx
Squamous cell carcinoma accounts for more than 90% of oropharyngeal malignancies. The increase in oropharyngeal squamous cell carcinoma (OPSCC) has been attributed to the increase in human papillomavirus (HPV)-positive tumors which portend more favorable outcomes when compared with carcinomas associated with chemical carcinogens. Diagnostic evaluation includes appropriate history, physical examination, imaging, and both diagnostic and interventional procedures. Therapeutic management is highly dependent on tumor stating, location, prognosis, and patient preference.
KeywordsOropharynx Squamous cell carcinoma Tobacco Alcohol HPV Lymphadenopathy Airway compromise Dysphagia Fiberoptic endoscopy CT MRI PET-CT Radiotherapy Chemotherapy Tracheotomy
- 1.Flint PW, Cummings WC. Malignant neoplasms of the oropharynx. In: Cummings otolaryngology: head and neck surgery. Philadelphia: Elsevier, Saunders; 2015.Google Scholar
- 5.Quon A, Fischbein NJ, McDougall IR, et al. Clinical role of F-FDG PET/CT in the management of squamous cell carcinoma of the head and neck and thyroid carcinoma. J Nucl Med. 2007;48(Suppl 1):58S–67S.Google Scholar
- 6.Yousem DM, Gad K, Tufano RP. Resectability issues with head and neck cancer. Am J Neuroradiol. 2006;27(10):2024–36.Google Scholar