Management of Squamous Cell Carcinoma of the Oropharynx

  • Laila Siddique
  • Tom Shokri
  • Neerav GoyalEmail author


Squamous cell carcinoma accounts for more than 90% of oropharyngeal malignancies. The increase in oropharyngeal squamous cell carcinoma (OPSCC) has been attributed to the increase in human papillomavirus (HPV)-positive tumors which portend more favorable outcomes when compared with carcinomas associated with chemical carcinogens. Diagnostic evaluation includes appropriate history, physical examination, imaging, and both diagnostic and interventional procedures. Therapeutic management is highly dependent on tumor stating, location, prognosis, and patient preference.


Oropharynx Squamous cell carcinoma Tobacco Alcohol HPV Lymphadenopathy Airway compromise Dysphagia Fiberoptic endoscopy CT MRI PET-CT Radiotherapy Chemotherapy Tracheotomy 


  1. 1.
    Flint PW, Cummings WC. Malignant neoplasms of the oropharynx. In: Cummings otolaryngology: head and neck surgery. Philadelphia: Elsevier, Saunders; 2015.Google Scholar
  2. 2.
    Wippold FJ. Head and neck imaging: the role of CT and MRI. J Magn Reson Imaging. 2007;25:453.CrossRefGoogle Scholar
  3. 3.
    Righi PD, Kopecky KK, Caldemeyer KS, et al. Comparison of the ultrasound- fine needle aspiration and computed tomography in patients undergoing elective neck dissection. Head Neck. 1997;19(7):604–10.CrossRefGoogle Scholar
  4. 4.
    Lewis JS, Thorstad WL, Chernock RD, et al. p16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status. Am J Surg Pathol. 2010;34(8):1088–96.CrossRefGoogle Scholar
  5. 5.
    Quon A, Fischbein NJ, McDougall IR, et al. Clinical role of F-FDG PET/CT in the management of squamous cell carcinoma of the head and neck and thyroid carcinoma. J Nucl Med. 2007;48(Suppl 1):58S–67S.Google Scholar
  6. 6.
    Yousem DM, Gad K, Tufano RP. Resectability issues with head and neck cancer. Am J Neuroradiol. 2006;27(10):2024–36.Google Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Otolaryngology-Head and Neck Surgery, Department of SurgeryPenn State Milton S. Hershey Medical CenterHersheyUSA
  2. 2.Department of Otolaryngology-Head and Neck SurgeryUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Penn State Cancer InstitutePenn State Milton S. Hershey Medical Center​HersheyUSA

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