Esophageal Carcinoma

  • Ruel Neupane
  • Wanda Lam
  • Jeffrey M. MarksEmail author


Esophageal cancer is the sixth leading cause of cancer death in the world and carries a 5-year survival rate of only 15–25%. A brief overview of presenting signs and symptoms as well as common manifestations of disease burden is presented. Review of the American Joint Committee on Cancer (AJCC) tumor/node/metastasis (TNM) classification provides insight to imaging and workup. Ultimately, staging dictates survival. Patient factors impacting surgical candidacy greatly impact the care patients diagnosed receive. Ultimately a multidisciplinary approach directs care.


Esophageal cancer Adenocarcinoma Squamous cell carcinoma Staging Esophagectomy Chemoradiation 


  1. 1.
    José M, Arnal D, Arenas ÁF, Arbeloa ÁL. Esophageal cancer: risk factors, screening and endoscopic treatment in Western and Eastern countries. World J Gastroenterol. 2015;21(26):7933–43.CrossRefGoogle Scholar
  2. 2.
    Enzinger PC, Mayer RJ. Esophageal cancer. N Engl J Med [Internet]. 2003;349(23):2241–52. Available from: Scholar
  3. 3.
    Townsend C, Bouchamp DB, Evers MB, Mattox K. Sabiston textbook of surgery: the biological basis of modern surgical practice. 20th ed. Philadelphia: Elsevier; 2016.Google Scholar
  4. 4.
    Varghese TK, Hofstetter WL, Rizk NP, Low DE, Darling GE, Watson TJ, et al. The society of thoracic surgeons guidelines on the diagnosis and staging of patients with esophageal cancer. Ann Thorac Surg [Internet]. 2013;96(1):346–56. Available from: Scholar
  5. 5.
    Rice TW, Patil DT, Blackstone EH. 8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice. Ann Cardiothorac Surg. 2017;6(2):119–30.CrossRefGoogle Scholar
  6. 6.
    Spechler SJ. Barrett esophagus and risk of esophageal cancer: a clinical review. JAMA [Internet]. 2013;310(6):627–36. Available from: Scholar
  7. 7.
    Kidane B, Coughlin S, Vogt K, Malthaner R. Preoperative chemotherapy for resectable thoracic esophageal cancer. Cochrane Database Syst Rev [Internet]. 2015;(5):CD001556. Available from:
  8. 8.
    Martin RCG, Cannon RM, Brown RE, Ellis SF, Williams S, Scoggins CR, et al. Evaluation of quality of life following placement of self-expanding plastic stents as a bridge to surgery in patients receiving neoadjuvant therapy for esophageal cancer. Oncologist [Internet]. 2014;19(3):259–65. Available from: Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of SurgeryUniversity Hospitals Cleveland Medical CenterClevelandUSA

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