Barrett’s Esophagitis

  • Caitlin A. HalbertEmail author
  • Anthony R. Tascone


Barrett’s esophagus is characterized by the replacement of stratified squamous epithelium by simple columnar epithelium with goblet cells. It is an ominous sequela of uncontrolled or poorly controlled gastroesophageal reflux disease. As a potential precursor to adenocarcinoma, Barrett’s esophagus can be devastating if undiagnosed or untreated. The ability to identify at-risk patients is imperative to provide prompt diagnosis. This is then followed by appropriate treatment dictated by the presence and degree of dysplasia. After therapy, endoscopic surveillance is vital to the lifelong care of patients with Barrett’s esophagus.


Barrett’s esophagus Barrett’s esophagitis Barrett’s syndrome Gastroesophageal reflux disease Endoscopic eradication therapy Antireflux surgery 


  1. 1.
    Spechler SJ, Sharma P, Souza RF, Inadomi JM, Shaheen NJ. American Gastroenterological Association medical position statement on the management of Barrett’s esophagus. Gastroenterology. 2011;140(3):1084–91.CrossRefGoogle Scholar
  2. 2.
    Freedberg DE, Kim LS, Yang Y-X. The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association. Gastroenterology [Internet]. 2017;152(4):706–15. Available from: Scholar
  3. 3.
    Kestens C, Offerhaus GJA, van Baal JWPM, Siersema PD. Patients with Barrett’s esophagus and persistent low-grade dysplasia have an increased risk for high-grade dysplasia and cancer. Clin Gastroenterol Hepatol. 2016;14(7):956–62.CrossRefGoogle Scholar
  4. 4.
    Stefanidis D, Hope WW, Kohn GP, Reardon PR, Richardson WS, Fanelli RD. Guidelines for surgical treatment of gastroesophageal reflux disease. Surg Endosc [Internet]. 2010;24(11):2647–69. Available from: Scholar
  5. 5.
    Wassenaar E, Oelschlager B. Effect of medical and surgical treatment of Barrett’s metaplasia. World J Gastroenterol. 2010;16(30):3773–9.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Advanced GI and Bariatric Surgery, Department of General SurgeryChristiana Care Health SystemNewarkUSA
  2. 2.Department of General SurgerySaint Luke’s Health SystemKansas CityUSA

Personalised recommendations