Abstract
Although most patients with systemic sclerosis (SSc)-related digital ulcers respond to medical management, a small but significant proportion benefit from surgical treatment. In our opinion the key aspect to successful surgical management is close communication between rheumatologist and surgeon with easy and rapid access to surgery. Fast access to surgical debridement will, in our opinion, often prevent the need for a more extensive surgical debridement or other surgical intervention.
The main indications for surgery are pain, non-healing, and the presence of underlying calcinosis. In this chapter we discuss the available surgical procedures. Surgical debridement and excision of calcinotic deposits are the two most commonly performed procedures. The use of periarterial sympathectomy is increasing. Amputation is required when all other measures fail, although it should be recognized that for many patients this is the best option for providing rapid pain relief, improved function, and also cosmetic relief from black fingers. Other surgical procedures to be considered (although less commonly performed) are balloon angioplasty, arterial reconstruction, and arthrodesis. The roles of botulinum toxin and of fat grafting are still to be evaluated fully.
Patients with SSc often have significant cardiorespiratory problems and thus an increased anesthetic risk; therefore, preoperative anesthetic consultation is advisable. Surgery may often be readily performed under regional anesthesia, for example, metacarpal block anesthesia.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Herrick A, Muir L. Raynaud's phenomenon (secondary). Systematic review 1125. BMJ Clinical Evidence. http://clinicalevidence.bmj.com/x/systematic-review/1125/overview.html. 2014 October.
Zhou AY, Muir L, Harris J, Herrick A. The impact of magnetic resonance imaging in early diagnosis of hand osteomyelitis in patients with systemic sclerosis. Clin Exp Rheumatol. 2014;32(Suppl 86):S-232.
Amanzi L, Braschi F, Fiori G, Galluccio F, Miniati I, Guiducci S, et al. Digital ulcers in scleroderma: staging, characteristics and sub-setting through observation of 1614 digital lesions. Rheumatology. 2010;49:1374–82.
Harrison BJ, Silman AJ, Hider SL, Herrick AL. Cigarette smoking as a significant risk factor for digital vascular disease in patients with systemic sclerosis. Arthritis Rheum. 2002;46:3312–6.
Nihtyanova SI, Brough GM, Black CM, Denton CP. Clinical burden of digital vasculopathy in limited and diffuse systemic sclerosis. Ann Rheum Dis. 2008;67:120–3.
Denton CP, Krieg T, Guillevin L, Schwierin B, Rosenberg D, Silkey M, et al. Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO registry. Ann Rheum Dis. 2012;71:718–21.
Yu HL, Chase RA, Strauch B. In atlas of hand anatomy and clinical implications, 68. St Louis: Mosby; 2004.
Koman LA, Paterson Smith B, Smith TL, Ruch DS, Li Z. Vascular disorders. In: Green's operative hand surgery, 2208. Philadelphia: Churchill Livingstone; 2011.
Chloros GD, Smerlis NN, Li Z, Smith TL, Smith BP, Koman A. Non invasive evaluation of upper extremity perfusion. J Hand Surg. 2008;33A:591–600.
Charkoudian N. Skin blood flow in adult human thermoregulation. How it works, when it does not, and why. Mayo Clin Proc. 2003;78:603–12.
Petrovsky JS. Resting blood flow in the skin: does it exist and what is the influence of temperature, aging and diabetes? J Diabetes Sci Technol. 2012;6:674–85.
Higgins JP, McClinton MA. Vascular insufficiency of the upper extremity. J Hand Surg. 2010;35A:1545–53.
Dumanian GA, Segalman K, Buehner JW, Koontz CL, Hendrickson M, Wilgis EF. Analysis of digital pulse-volume recordings with radial and ulnar artery compression. Plast Reconstr Surg. 1998;102:1993–8.
Kim YH, Ng SW, Seo HS, Ahn HC. Classification of Raynaud's disease based on angiographic features. J Plast Reconstr Surg. 2011;64:1503–11.
Janevski B. Arteries of the hand in patients with scleroderma. Diagn Imag Clin Med. 1986;55:262–5.
Park JA, Sung YK, Bae SC, Song SY, Seo HS, Jun JB. Ulnar artery vasculopathy in systemic sclerosis. Rheumatol Int. 2009;29:1081–6.
Ho M, Veale D, Eastmond C, Nuki G, Belch J. Macrovascular disease and systemic sclerosis. Ann Rheum Dis. 2000;59:39–43.
Merritt WH. Role and rationale for extended periarterial sympathectomy in the management of severe Raynaud syndrome. Hand Clin. 2015;31:101–20.
Sandqvist G, Eklund M. Validity of HAMIS: a test of hand mobility in scleroderma. Arthritis Care Res. 2000;13:382–7.
Steen VD, Medsger TA. The value of the Health Assessment Questionnaire and special patient-generated scales to demonstrate change in systemic sclerosis patients over time. Arthritis Rheum. 1997;40:1984–91.
Silman A, Akesson A, Newman J, Henriksson H, Sandquist G, Nihill M, et al. Assessment of functional ability in patients with scleroderma: a proposed new disability assessment instrument. J Rheumatol. 1998;25:79–83.
Brower LM, Poole JL. Reliability and validity of the Duruoz hand index in persons with systemic sclerosis (scleroderma). Arthritis Care Res. 2004;51:805–9.
Hudak P, Amadio PC, Bombardier C, the Upper Extremity Collaborative Group. Development of an Upper Extremity Outcome Measure: The DASH (Disabilities of the Arm, Shoulder, and Hand). Am J Ind Med. 1996;29:602–8.
Claes G, Droyt C, Göthberg G. Thoracoscopic sympathectomy for arterial insufficiency. Eur J Surg Suppl. 1994;572:63–4.
Flatt AE. Digital artery sympathectomy. J Hand Surg. 1980;5:550–6.
Morgan RF, Wilgis EF. Thermal changes in a rabbit ear model after sympathectomy. J Hand Surg. 1986;11:120–4.
Balogh B, Mayer W, Vesely M, Mayer S, Partsch H, Piza-Katzer H. Adventitial stripping of the radial and ulnar arteries in Raynaud's disease. J Hand Surg. 2002;27A:1073–80.
Balogh B, Valencak J, Vesely M, Flammer M, Gruber H, Piza-Katzer H. The nerve of Henle: an anatomic and immunohistochemical study. J Hand Surg. 1999;24A:1103–8.
Hartzell TL, Makhni EC, Sampson C. Long term results of periarterial sympathectomy. J Hand Surg. 2009;34A:1454–60.
Koman AL, Smith BP, Pollock FE, Smith TL, Pollock D, Russell GB. The microcirculatory effects of peripheral sympathectomy. J Hand Surg. 1995;20:709–17.
Kotsis AV, Chung KC. A systematic review of the outcomes of digital sympathectomy for treatment of chronic ischaemia. J Rheumatol. 2003;30:1788–92.
Yee AMF, Hotchkiss RN, Paget SA. Adventitial stripping: a digit saving procedure in refractory Raynaud’s phenomenon. J Rheumatol. 1998;25:269–76.
O’Brien BMC, Kumar PAV, Mellow CG, Oliver TV. Radical microarteriolysis in the treatment of vasospastic disorders of the hand, especially scleroderma. J Hand Surg Eur. 1992;17:447–52.
Tomaino MM. Digital arterial occlusion in scleroderma: is there a role for digital arterial reconstruction? J Hand Surg Eur. 2000;25:611–3.
Trocchia AM, Hammert WC. Arterial grafts for vascular reconstruction in the upper extremity. J Hand Surg. 2011;36A:1534–6.
Kryger ZB, Rawlani V, Dumanian GA. Treatment of chronic digital ischaemia with direct microsurgical revascularisation. J Hand Surg. 2007;32:1466–70.
Kind GM. Arterialization of the venous system of the hand. Plast Reconstr Surg. 2006;118:421–8.
Matarrese MR, Hammert WC. Revascularization of the ischemic hand with arterialization of the venous system. J Hand Surg. 2011;36A:2047–51.
Bank J, Fuller SM, Henry GI, Zachary LS. Fat grafting to the hand in patients with Raynaud phenomenon. Plast Reconst Surg. 2014;133:1109.
Del Papa N, Di Luca G, Sambataro D, Zaccara E, Maglione W, Gabrielli A, et al. Regional implantation of autologous adipose tissue-derived cells induces a prompt healing of long-lasting indolent digital ulcers in patients with systemic sclerosis. Cell Transplant. 2015;24:2297–305.
Guillaume-Jugnot P, Daumas A, Magalon J, Jouve E, Nguyen P-S, Truillet R, et al. Autologous adipose-derived stromal vascular fraction in patients with systemic sclerosis: 12-month follow-up. Rheumatology. 2016;55:301–6.
Guillaume-Jugnot P, Daumas A, Magalon J, Sautereau N, Veran J, Magalon G, et al. State of the art. Autologous fat graft and adipose tissue-derived stromal vascular fraction injection for hand therapy in systemic sclerosis patients. Curr Res Translation Med. 2016;64:35–42.
Del Papa N, Zaccara E, Di Luca G, Andracco R, Maglione W, Vitali C. Adipose-derived cell transplantation in systemic sclerosis: state of the art and future perspectives. J Scler Relat Dis. 2017;2:33–41.
Jones NF, Imbriglia JE, Steen VD, Medsger TA. Surgery for scleroderma of the hand. J Hand Surg. 1987;12A:391–400.
Nalebuff EA. Surgery in patients with systemic sclerosis of the hand. Clin Orthop Relat Res. 1999;366:91–7.
Anandacoomarasamy A, Englert H, Manolios N, Kirkham S. Reconstructive hand surgery for scleroderma joint contractures. J Hand Surg. 2007;32A:1107–12.
Gilbart MK, Jolles BM, Lee P, Bogoch ER. Surgery of the hand in severe systemic sclerosis. J Hand Surg (Eur). 2004;29:599–603.
Thibaudeau S, Serebrakian AT, Gerety PA, Levin LS. An algorithmic approach to the surgical treatment of chronic ischaemia of the hand: a systematic review of the literature. Plast Reconstr Surg. 2016;137:818e–28e.
Muir L. Surgical management. In: Wigley F, Herrick A, Flavahan N, editors. Raynaud’s phenomenon. New York, NY: Springer; 2015.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Muir, L., Herrick, A.L. (2019). Surgical Approaches Including Sympathectomy. In: Matucci-Cerinic, M., Denton, C. (eds) Atlas of Ulcers in Systemic Sclerosis. Springer, Cham. https://doi.org/10.1007/978-3-319-98477-3_21
Download citation
DOI: https://doi.org/10.1007/978-3-319-98477-3_21
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-98475-9
Online ISBN: 978-3-319-98477-3
eBook Packages: MedicineMedicine (R0)