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Therapeutic Antibodies

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Introduction to Biologic and Biosimilar Product Development and Analysis

Part of the book series: AAPS Introductions in the Pharmaceutical Sciences ((AAPSINSTR))

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Abstract

Monoclonal antibodies are the most rapidly growing area of drug research and development. Their ability to target certain cell surface antigens has been advantageous in cancer and transplant therapy, though many early, mouse-derived products had limited long-term use due to the potential for immunogenicity. Advances in recombinant technology and the ability to make antibodies less immunogenic by making them more human have led to routine use in chronic conditions as well. While all products currently marketed are injectable, a number of those targeted at autoimmune conditions such as rheumatoid arthritis, psoriasis, and related conditions are available in easy-to-use self-injection systems.

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Authors and Affiliations

  1. Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA

    Karen M. Nagel

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Nagel, K.M. (2018). Therapeutic Antibodies. In: Introduction to Biologic and Biosimilar Product Development and Analysis. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-319-98428-5_3

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