Abstract
This thesis demonstrates the potential of hyper and multispectral cameras based on commercial SRDA technology for multiplexed biomedical fluorescence imaging. Following a detailed calibration of commercial SRDAs, their potential in two biomedical imaging applications were studied; wide-field fHSI and MSI endoscopy. In the process of system integration of the sensors, the calibration methods, instrumentation challenges and data analysis protocols for effective use of SRDAs in biomedical imaging applications were explored.
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References
H.A. Macleod, Chapter 6: Edge filters and Chapter 7: Band-pass filters, Thin Film Optical Filters, 3rd edn. (IoP, Bristol, 2000)
M. Jayapala et al., Monolithic integration of flexible spectral filters with CMOS image sensors at wafer level for low cost hyperspectral imaging in international image sensor workshop, in Snowbird (2013)
P. Agrawal et al., Characterization of VNIR hyperspectral sensors with monolithically integrated optical filters, in Proceedings of IS&T International Symposium on Electronic Imaging, 2016 (2016)
T. Sawyer, A.S. Luthman, S.E. Bohndiek, Evaluation of illumination system uniformity for wide-field biomedical hyperspectral imaging. J. Opt. 19(4), 045301 (2017)
A.J. Chaudhari et al., Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging. Phys. Med. Biol. 50, 5421–5441 (2005)
P.A. Valdes et al., Quantitative, spectrally-resolved intraoperative fluorescence imaging. Sci. Rep. 2(798) (2012)
M. Jermyn et al., Macroscopic-imaging technique for subsurface quantification of near-infrared markers during surgery. J. Biomed. Opt. 20(3), 036014 (2015)
S. Tzoumas, N.C. Deliolanis, S. Morscher, V. Ntziachristos, Unmixing molecular agents from absorbing tissue in multispectral optoacoustic tomography. IEEE Trans. Med. Imaging 33(1), 48–60 (2014)
ASGE, High-definition and high-magnification endoscopes. Gastrointest. Endosc. 80(6), 919–927 (2014)
B.P. Joshi et al., Multimodal endoscope can quantify wide-field fluorescence detection of Barrett’s neoplasia. Endoscopy 48(2), A1–A13 (2015)
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Luthman, A.S. (2018). Conclusions and Outlook. In: Spectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-98255-7_5
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DOI: https://doi.org/10.1007/978-3-319-98255-7_5
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