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Cardiac Remodeling: The Course Towards Heart Failure-II. Diagnostic and Therapeutic Approaches

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Abstract

The diagnosis of cardiac remodeling (REM) is based on echocardiographic, radionuclide, and cardiac magnetic resonance imaging. With all of these three modalities, molecular imaging investigating various processes can be implemented. With regard to therapy, pharmaceutical treatment is still evolving: angiotensing converting enzyme inhibitors or angiotensin II receptor blockers, beta blockers, aldosterone inhibitors and statins are the big 4 of therapy. Revascularization is an option if viability is found. In cases of left bundle branch block (LBBB), resynchronization therapy can be effective, especially in nonischemic etiology. Gene therapy by SERCA-2 gene transfer has been investigated but the results of CUPID 2 were disappointing. Progenitor cell therapy still remains under evaluation. Finally, with left ventricular assist device (LVAD) placement, improved results are reported with regard to both weaning from mechanical circulation support and overall survival.

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    Dennis V. Cokkinos

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Cokkinos, D.V. (2019). Cardiac Remodeling: The Course Towards Heart Failure-II. Diagnostic and Therapeutic Approaches. In: Cokkinos, D. (eds) Myocardial Preservation. Springer, Cham. https://doi.org/10.1007/978-3-319-98186-4_13

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