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Healthcare-Associated Gastrointestinal Infections

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Healthcare-Associated Infections in Children
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Abstract

Diarrhea is relatively common among hospitalized children. Most episodes of nosocomial diarrhea are due to noninfectious factors, including medications, underlying illnesses, or tube feeding. Yet the acute onset of diarrhea in a hospitalized child may indicate a newly acquired gastrointestinal infection. Clostridium difficile, norovirus, and rotavirus can cause sporadic or epidemic disease in pediatric inpatient settings. Early recognition of these enteric infections is important as it permits efficient and effective patient care and allows for prompt implementation of infection control measures. This chapter describes the epidemiology, diagnosis, and management of healthcare-associated enteric infections important to the pediatric population. Additionally, strategies to prevent the spread of diarrheal pathogens are reviewed.

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References

  1. Scallan E, Griffin PM, Angulo FJ, Tauxe RV, Hoekstra RM. Foodborne illness acquired in the United States--unspecified agents. Emerg Infect Dis. 2011;17:16–22.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Jones TF, McMillian MB, Scallan E, et al. A population-based estimate of the substantial burden of diarrhoeal disease in the United States; FoodNet, 1996–2003. Epidemiol Infect. 2007;135:293–301.

    Article  CAS  PubMed  Google Scholar 

  3. Brady MT, Pacini DL, Budde CT, Connell MJ. Diagnostic studies of nosocomial diarrhea in children: assessing their use and value. Am J Infect Control. 1989;17:77–82.

    Article  CAS  PubMed  Google Scholar 

  4. Ford-Jones EL, Mindorff CM, Langley JM, et al. Epidemiologic study of 4684 hospital-acquired infections in pediatric patients. Pediatr Infect Dis J. 1989;8:668–75.

    Article  CAS  PubMed  Google Scholar 

  5. Langley JM, LeBlanc JC, Hanakowski M, Goloubeva O. The role of Clostridium difficile and viruses as causes of nosocomial diarrhea in children. Infect Control Hosp Epidemiol. 2002;23:660–4.

    Article  PubMed  Google Scholar 

  6. Kamalaratnam CN, Kang G, Kirubakaran C, et al. A prospective study of nosocomial enteric pathogen acquisition in hospitalized children in South India. J Trop Pediatr. 2001;47:46–9.

    Article  CAS  PubMed  Google Scholar 

  7. Ford-Jones EL, Mindorff CM, Gold R, Petric M. The incidence of viral-associated diarrhea after admission to a pediatric hospital. Am J Epidemiol. 1990;131:711–8.

    Article  CAS  PubMed  Google Scholar 

  8. Sidler JA, Haberthur C, Dumoulin A, Hirsch HH, Heininger U. A retrospective analysis of nosocomial viral gastrointestinal and respiratory tract infections. Pediatr Infect Dis J. 2012;31:1233–8.

    Article  PubMed  Google Scholar 

  9. Kim J, Smathers SA, Prasad P, Leckerman KH, Coffin S, Zaoutis T. Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001–2006. Pediatrics. 2008;122:1266–70.

    Article  PubMed  Google Scholar 

  10. Anderson EJ, Rupp A, Shulman ST, Wang D, Zheng X, Noskin GA. Impact of rotavirus vaccination on hospital-acquired rotavirus gastroenteritis in children. Pediatrics. 2011;127:e264–70.

    Article  PubMed  Google Scholar 

  11. Payne DC, Vinje J, Szilagyi PG, et al. Norovirus and medically attended gastroenteritis in U.S. children. N Engl J Med. 2013;368:1121–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Chandra BK, Singh G, Taneja N, Pahil S, Singhi S, Sharma M. Diarrhoeagenic Escherichia coli as a predominant cause of paediatric nosocomial diarrhoea in India. J Med Microbiol. 2012;61:830–6.

    Article  CAS  PubMed  Google Scholar 

  13. Raymond J, Aujard Y. Nosocomial infections in pediatric patients: a European, multicenter prospective study. European Study Group. Infect Control Hosp Epidemiol. 2000;21:260–3.

    Article  CAS  PubMed  Google Scholar 

  14. Rutledge-Taylor K, Matlow A, Gravel D, et al. A point prevalence survey of health care-associated infections in Canadian pediatric inpatients. Am J Infect Control. 2012;40:491–6.

    Article  PubMed  Google Scholar 

  15. Fischer TK, Bresee JS, Glass RI. Rotavirus vaccines and the prevention of hospital-acquired diarrhea in children. Vaccine. 2004;22(Suppl 1):S49–54.

    Article  CAS  PubMed  Google Scholar 

  16. Harris JP, Lopman BA, Cooper BS, O'Brien SJ. Does spatial proximity drive norovirus transmission during outbreaks in hospitals? BMJ Open. 2013;3:e003060.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Sandora TJ, Fung M, Flaherty K, et al. Epidemiology and risk factors for Clostridium difficile infection in children. Pediatr Infect Dis J. 2011;30:580–4.

    Article  PubMed  Google Scholar 

  18. Cunliffe NA, Booth JA, Elliot C, et al. Healthcare-associated viral gastroenteritis among children in a large pediatric hospital, United Kingdom. Emerg Infect Dis. 2010;16:55–62.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Ye X, Van JN, Munoz FM, et al. Noroviruses as a cause of diarrhea in immunocompromised pediatric hematopoietic stem cell and solid organ transplant recipients. Am J Transplant. 2015;15:1874–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Crews JD, Koo HL, Jiang ZD, Starke JR, DuPont HL. A hospital-based study of the clinical characteristics of Clostridium difficile infection in children. Pediatr Infect Dis J. 2014;33:924–8.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Khanna S, Baddour LM, Huskins WC, et al. The epidemiology of Clostridium difficile infection in children: a population-based study. Clin Infect Dis. 2013;56:1401–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Shane AL, Mody RK, Crump JA, et al. 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clin Infect Dis. 2017;65:1963–73.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Bauer TM, Lalvani A, Fehrenbach J, et al. Derivation and validation of guidelines for stool cultures for enteropathogenic bacteria other than Clostridium difficile in hospitalized adults. JAMA. 2001;285:313–9.

    Article  CAS  PubMed  Google Scholar 

  24. Zaidi AK, Macone A, Goldmann AD. Impact of simple screening criteria on utilization of low-yield bacterial stool cultures in a children’s hospital. Pediatrics. 1999;103:1189–92.

    Article  CAS  PubMed  Google Scholar 

  25. Binnicker MJ. Multiplex molecular panels for diagnosis of gastrointestinal infection: performance, result interpretation, and cost-effectiveness. J Clin Microbiol. 2015;53:3723–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Ahmed SM, Hall AJ, Robinson AE, et al. Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis. Lancet Infect Dis. 2014;14:725–30.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Huhti L, Szakal ED, Puustinen L, et al. Norovirus GII-4 causes a more severe gastroenteritis than other noroviruses in young children. J Infect Dis. 2011;203:1442–4.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Vega E, Barclay L, Gregoricus N, Shirley SH, Lee D, Vinje J. Genotypic and epidemiologic trends of norovirus outbreaks in the United States, 2009–2013. J Clin Microbiol. 2014;52:147–55.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  29. Barclay L, Park GW, Vega E, et al. Infection control for norovirus. Clin Microbiol Infect. 2014;20:731–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Harris JP, Lopman BA, O’Brien SJ. Infection control measures for norovirus: a systematic review of outbreaks in semi-enclosed settings. J Hosp Infect. 2010;74:1–9.

    Article  CAS  PubMed  Google Scholar 

  31. Munir N, Liu P, Gastanaduy P, Montes J, Shane A, Moe C. Norovirus infection in immunocompromised children and children with hospital-acquired acute gastroenteritis. J Med Virol. 2014;86:1203–9.

    Article  PubMed  Google Scholar 

  32. Sukhrie FH, Teunis P, Vennema H, et al. Nosocomial transmission of norovirus is mainly caused by symptomatic cases. Clin Infect Dis. 2012;54:931–7.

    Article  PubMed  Google Scholar 

  33. Turcios RM, Widdowson MA, Sulka AC, Mead PS, Glass RI. Reevaluation of epidemiological criteria for identifying outbreaks of acute gastroenteritis due to norovirus: United States, 1998–2000. Clin Infect Dis. 2006;42:964–9.

    Article  PubMed  Google Scholar 

  34. Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI. Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis. 2003;9:565–72.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Parashar UD, Nelson EA, Kang G. Diagnosis, management, and prevention of rotavirus gastroenteritis in children. BMJ (Clinical research ed). 2013;347:f7204.

    Google Scholar 

  36. Gleizes O, Desselberger U, Tatochenko V, et al. Nosocomial rotavirus infection in European countries: a review of the epidemiology, severity and economic burden of hospital-acquired rotavirus disease. Pediatr Infect Dis J. 2006;25:S12–21.

    Article  PubMed  Google Scholar 

  37. Bruijning-Verhagen P, Quach C, Bonten M. Nosocomial rotavirus infections: a meta-analysis. Pediatrics. 2012;129:e1011–9.

    Article  PubMed  Google Scholar 

  38. Zlamy M, Kofler S, Orth D, et al. The impact of Rotavirus mass vaccination on hospitalization rates, nosocomial Rotavirus gastroenteritis and secondary blood stream infections. BMC Infect Dis. 2013;13:112.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Gianino P, Mastretta E, Longo P, et al. Incidence of nosocomial rotavirus infections, symptomatic and asymptomatic, in breast-fed and non-breast-fed infants. J Hosp Infect. 2002;50:13–7.

    Article  CAS  PubMed  Google Scholar 

  40. Gervasi G, Capanna A, Mita V, Zaratti L, Franco E. Nosocomial rotavirus infection: an up to date evaluation of European studies. Hum Vaccin Immunother. 2016;12:2413–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Verhagen P, Moore D, Manges A, Quach C. Nosocomial rotavirus gastroenteritis in a Canadian paediatric hospital: incidence, disease burden and patients affected. J Hosp Infect. 2011;79:59–63.

    Article  CAS  PubMed  Google Scholar 

  42. Pickering LK, Bartlett AV 3rd, Reves RR, Morrow A. Asymptomatic excretion of rotavirus before and after rotavirus diarrhea in children in day care centers. J Pediatr. 1988;112:361–5.

    Article  CAS  PubMed  Google Scholar 

  43. Carraturo A, Catalani V, Tega L. Microbiological and epidemiological aspects of rotavirus and enteric adenovirus infections in hospitalized children in Italy. New Microbiol. 2008;31:329–36.

    PubMed  Google Scholar 

  44. Mattner F, Sykora KW, Meissner B, Heim A. An adenovirus type F41 outbreak in a pediatric bone marrow transplant unit: analysis of clinical impact and preventive strategies. Pediatr Infect Dis J. 2008;27:419–24.

    Article  PubMed  Google Scholar 

  45. Galdiero E, Marinelli A, Pisciotta MG, Pagliara I, Di Monteforte ES, Liguori G. Reverse transcriptase-PCR for the detection of Astrovirus in children with nosocomial acute diarrhoea in Naples, Italy. Med Mal Infect. 2005;35:213–7.

    Article  PubMed  Google Scholar 

  46. Shastri S, Doane AM, Gonzales J, Upadhyayula U, Bass DM. Prevalence of astroviruses in a children’s hospital. J Clin Microbiol. 1998;36:2571–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Lyman WH, Walsh JF, Kotch JB, Weber DJ, Gunn E, Vinje J. Prospective study of etiologic agents of acute gastroenteritis outbreaks in child care centers. J Pediatr. 2009;154:253–7.

    Article  PubMed  Google Scholar 

  48. Pang XL, Lee BE, Tyrrell GJ, Preiksaitis JK. Epidemiology and genotype analysis of sapovirus associated with gastroenteritis outbreaks in Alberta, Canada: 2004–2007. J Infect Dis. 2009;199:547–51.

    Article  PubMed  Google Scholar 

  49. Brown JR, Shah D, Breuer J. Viral gastrointestinal infections and norovirus genotypes in a paediatric UK hospital, 2014–2015. J Clin Virol. 2016;84:1–6.

    Article  PubMed  Google Scholar 

  50. Lessa FC, Winston LG, McDonald LC, Emerging Infections Program CdST. Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015;372:2369–70.

    Article  PubMed  CAS  Google Scholar 

  51. McDonald LC, Killgore GE, Thompson A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med. 2005;353:2433–41.

    Article  CAS  PubMed  Google Scholar 

  52. Zilberberg MD, Tillotson GS, McDonald C. Clostridium difficile infections among hospitalized children, United States, 1997–2006. Emerg Infect Dis. 2010;16:604–9.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Nylund CM, Goudie A, Garza JM, Fairbrother G, Cohen MB. Clostridium difficile infection in hospitalized children in the United States. Arch Pediatr Adolesc Med. 2011;165:451–7.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Wendt JM, Cohen JA, Mu Y, et al. Clostridium difficile infection among children across diverse US geographic locations. Pediatrics. 2014;133:651–8.

    Article  PubMed  Google Scholar 

  55. Sammons JS, Localio R, Xiao R, Coffin SE, Zaoutis T. Clostridium difficile infection is associated with increased risk of death and prolonged hospitalization in children. Clin Infect Dis. 2013;57:1–8.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Crews JD, Anderson LR, Waller DK, Swartz MD, DuPont HL, Starke JR. Risk factors for community-associated Clostridium difficile-associated diarrhea in children. Pediatr Infect Dis J. 2015;34:919–23.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Adams DJ, Eberly MD, Rajnik M, Nylund CM. Risk factors for community-associated Clostridium difficile infection in children. J Pediatr. 2017;186:105–9.

    Article  PubMed  Google Scholar 

  58. Freedberg DE, Lamouse-Smith ES, Lightdale JR, Jin Z, Yang YX, Abrams JA. Use of acid suppression medication is associated with risk for C. difficile infection in infants and children: a population-based study. Clin Infect Dis. 2015;61:912–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Nylund CM, Eide M, Gorman GH. Association of Clostridium difficile infections with acid suppression medications in children. J Pediatr. 2014;165:979–84 e1.

    Article  CAS  PubMed  Google Scholar 

  60. Crobach MJ, Planche T, Eckert C, et al. European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infection. Clin Microbiol Infect. 2016;22(Suppl 4):S63–81.

    Article  PubMed  Google Scholar 

  61. McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66:e1–e48.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Schutze GE, Willoughby RE, Committee on Infectious D and American Academy of P. Clostridium difficile infection in infants and children. Pediatrics. 2013;131:196–200.

    Article  PubMed  Google Scholar 

  63. Nicholson MR, Freswick PN, Di Pentima MC, et al. The use of a computerized provider order entry alert to decrease rates of Clostridium difficile testing in young pediatric patients. Infect Control Hosp Epidemiol. 2017;38:542–6.

    Article  PubMed  Google Scholar 

  64. Kociolek LK, Bovee M, Carter D, et al. Impact of a healthcare provider educational intervention on frequency of Clostridium difficile polymerase chain reaction testing in children: a segmented regression analysis. J Pediatr Infect Dis Soc. 2017;6:142–8.

    Google Scholar 

  65. Deshpande A, Pasupuleti V, Patel P, et al. Repeat stool testing to diagnose Clostridium difficile infection using enzyme immunoassay does not increase diagnostic yield. Clin Gastroenterol Hepatol. 2011;9:665–9 e1.

    Article  PubMed  Google Scholar 

  66. Nelson RL, Suda KJ, Evans CT. Antibiotic treatment for Clostridium difficile-associated diarrhoea in adults. Cochrane Database Syst Rev. 2017;3:CD004610.

    PubMed  Google Scholar 

  67. Nicholson MR, Thomsen IP, Slaughter JC, Creech CB, Edwards KM. Novel risk factors for recurrent Clostridium difficile infection in children. J Pediatr Gastroenterol Nutr. 2015;60:18–22.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Tschudin-Sutter S, Tamma PD, Milstone AM, Perl TM. Predictors of first recurrence of Clostridium difficile infections in children. Pediatr Infect Dis J. 2014;33:414–6.

    Article  PubMed  Google Scholar 

  69. Sirbu BD, Soriano MM, Manzo C, Lum J, Gerding DN, Johnson S. Vancomycin taper and pulse regimen with careful follow-up for patients with recurrent Clostridium difficile infection. Clin Infect Dis. 2017;65:1396–9.

    Article  PubMed  Google Scholar 

  70. Hota SS, Sales V, Tomlinson G, et al. Oral vancomycin followed by fecal transplantation versus tapering oral vancomycin treatment for recurrent Clostridium difficile infection: an open-label, randomized controlled trial. Clin Infect Dis. 2017;64:265–71.

    Article  PubMed  Google Scholar 

  71. Cornely OA, Crook DW, Esposito R, et al. Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. Lancet Infect Dis. 2012;12:281–9.

    Article  CAS  PubMed  Google Scholar 

  72. Lee MB, Greig JD. A review of nosocomial Salmonella outbreaks: infection control interventions found effective. Public Health. 2013;127:199–206.

    Article  CAS  PubMed  Google Scholar 

  73. Bornemann R, Zerr DM, Heath J, et al. An outbreak of Salmonella serotype Saintpaul in a children's hospital. Infect Control Hosp Epidemiol. 2002;23:671–6.

    Article  PubMed  Google Scholar 

  74. Robertson P, Smith A, Anderson M, et al. Transmission of Salmonella enteritidis after endoscopic retrograde cholangiopancreatography because of inadequate endoscope decontamination. Am J Infect Control. 2017;45:440–2.

    Article  PubMed  Google Scholar 

  75. Suleyman G, Tibbetts R, Perri MB, et al. Nosocomial outbreak of a novel extended-spectrum beta-lactamase Salmonella enterica Serotype Isangi among surgical patients. Infect Control Hosp Epidemiol. 2016;37:954–61.

    Article  PubMed  Google Scholar 

  76. Spearing NM, Jensen A, McCall BJ, Neill AS, McCormack JG. Direct costs associated with a nosocomial outbreak of Salmonella infection: an ounce of prevention is worth a pound of cure. Am J Infect Control. 2000;28:54–7.

    Article  CAS  PubMed  Google Scholar 

  77. Alrifai SB, Alsaadi A, Mahmood YA, Ali AA, Al-Kaisi LA. Prevalence and etiology of nosocomial diarrhoea in children < 5 years in Tikrit teaching hospital. East Mediterr Health J/La revue de sante de la Mediterranee orientale/al-Majallah al-sihhiyah li-sharq al-mutawassit. 2009;15:1111–8.

    CAS  Google Scholar 

  78. Gerards LJ, Hennekam RC, von Dijk WC, Roord JJ, Fleer A. An outbreak of gastroenteritis due to Escherichia coli 0142 H6 in a neonatal department. J Hosp Infect. 1984;5:283–8.

    Article  CAS  PubMed  Google Scholar 

  79. Boyer KM, Petersen NJ, Farzaneh I, Pattison CP, Hart MC, Maynard JE. An outbreak og gastroenteritis due to E. coli 0142 in a neonatal nursery. J Pediatr. 1975;86:919–27.

    Article  CAS  PubMed  Google Scholar 

  80. Ryder RW, Wachsmuth IK, Buxton AE, et al. Infantile diarrhea produced by heat-stable enterotoxigenic Escherichia coli. N Engl J Med. 1976;295:849–53.

    Article  CAS  PubMed  Google Scholar 

  81. Taneja N, Das A, Raman Rao DS, Jain N, Singh M, Sharma M. Nosocomial outbreak of diarrhoea by enterotoxigenic Escherichia coli among preterm neonates in a tertiary care hospital in India: pitfalls in healthcare. J Hosp Infect. 2003;53:193–7.

    Article  CAS  PubMed  Google Scholar 

  82. Zeng M, Shi W, Chang H, et al. Clonal spread of enterotoxigenic Escherichia coli O128:H45 strain in the neonate unit. Jpn J Infect Dis. 2016;69:127–30.

    Article  CAS  PubMed  Google Scholar 

  83. O’Brien SJ, Murdoch PS, Riley AH, et al. A foodborne outbreak of Vero cytotoxin-producing Escherichia coli O157:H-phage type 8 in hospital. J Hosp Infect. 2001;49:167–72.

    Article  PubMed  Google Scholar 

  84. Weightman NC, Kirby PJ. Nosocomial Escherichia coli O157 infection. J Hosp Infect. 2000;44:107–11.

    Article  CAS  PubMed  Google Scholar 

  85. Jelovcan S, Schmid D, Lederer I, et al. Cluster of nosocomial campylobacteriosis, Austria 2006. J Hosp Infect. 2008;69:97–8.

    Article  CAS  PubMed  Google Scholar 

  86. Morooka T, Umeda A, Fujita M, et al. Epidemiologic application of pulsed-field gel electrophoresis to an outbreak of Campylobacter fetus meningitis in a neonatal intensive care unit. Scand J Infect Dis. 1996;28:269–70.

    Article  CAS  PubMed  Google Scholar 

  87. Rautelin H, Koota K, von Essen R, Jahkola M, Siitonen A, Kosunen TU. Waterborne Campylobacter jejuni epidemic in a Finnish hospital for rheumatic diseases. Scand J Infect Dis. 1990;22:321–6.

    Article  CAS  PubMed  Google Scholar 

  88. Mazengia E, Kawakami V, Rietberg K, et al. Hospital-acquired listeriosis linked to a persistently contaminated milkshake machine. Epidemiol Infect. 2017;145:857–63.

    Article  CAS  PubMed  Google Scholar 

  89. Johnsen BO, Lingaas E, Torfoss D, Strom EH, Nordoy I. A large outbreak of Listeria monocytogenes infection with short incubation period in a tertiary care hospital. J Infect. 2010;61:465–70.

    Article  PubMed  Google Scholar 

  90. Centers for Disease C. Hospital-associated outbreak of Shigella dysenteriae type 2–Maryland. MMWR Morb Mortal Wkly Rep. 1983;32:250–2.

    Google Scholar 

  91. Beers LM, Burke TL, Martin DB. Shigellosis occurring in newborn nursery staff. Infect Control Hosp Epidemiol. 1989;10:147–9.

    Article  CAS  PubMed  Google Scholar 

  92. Bwire G, Malimbo M, Kagirita A, et al. Nosocomial cholera outbreak in a mental hospital: challenges and lessons learnt from Butabika National Referral Mental Hospital, Uganda. Am J Trop Med Hyg. 2015;93:534–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Philip NA, Ahmed N, Pitchumoni CS. Spectrum of drug-induced chronic diarrhea. J Clin Gastroenterol. 2017;51:111–7.

    Article  CAS  PubMed  Google Scholar 

  94. Abraham B, Sellin JH. Drug-induced diarrhea. Curr Gastroenterol Rep. 2007;9:365–72.

    Article  PubMed  Google Scholar 

  95. Johnston BC, Goldenberg JZ, Parkin PC. Probiotics and the prevention of antibiotic-associated diarrhea in infants and children. JAMA. 2016;316:1484–5.

    Article  PubMed  Google Scholar 

  96. McFarland LV. Antibiotic-associated diarrhea: epidemiology, trends and treatment. Future Microbiol. 2008;3:563–78.

    Article  PubMed  Google Scholar 

  97. Kinlay J, Sandora TJ. A qualitative study to identify reasons for Clostridium difficile testing in pediatric inpatients receiving laxatives or stool softeners. Am J Infect Control. 2017;45:539–41.

    Article  PubMed  Google Scholar 

  98. Ista E, van Dijk M, Gamel C, Tibboel D, de Hoog M. Withdrawal symptoms in critically ill children after long-term administration of sedatives and/or analgesics: a first evaluation. Crit Care Med. 2008;36:2427–32.

    Article  CAS  PubMed  Google Scholar 

  99. Blumenstein I, Shastri YM, Stein J. Gastroenteric tube feeding: techniques, problems and solutions. World J Gastroenterol. 2014;20:8505–24.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Zerr DM, Allpress AL, Heath J, Bornemann R, Bennett E. Decreasing hospital-associated rotavirus infection: a multidisciplinary hand hygiene campaign in a children’s hospital. Pediatr Infect Dis J. 2005;24:397–403.

    Article  PubMed  Google Scholar 

  101. Tuladhar E, Hazeleger WC, Koopmans M, Zwietering MH, Duizer E, Beumer RR. Reducing viral contamination from finger pads: handwashing is more effective than alcohol-based hand disinfectants. J Hosp Infect. 2015;90:226–34.

    Article  CAS  PubMed  Google Scholar 

  102. Jabbar U, Leischner J, Kasper D, et al. Effectiveness of alcohol-based hand rubs for removal of Clostridium difficile spores from hands. Infect Control Hosp Epidemiol. 2010;31:565–70.

    Article  PubMed  Google Scholar 

  103. Dubberke ER, Carling P, Carrico R, et al. Strategies to prevent Clostridium difficile infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35:628–45.

    Article  PubMed  Google Scholar 

  104. MacCannell T, Umscheid CA, Agarwal RK, et al. Guideline for the prevention and control of norovirus gastroenteritis outbreaks in healthcare settings. Infect Control Hosp Epidemiol. 2011;32:939–69.

    Article  PubMed  Google Scholar 

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Crews, J.D. (2019). Healthcare-Associated Gastrointestinal Infections. In: McNeil, J., Campbell, J., Crews, J. (eds) Healthcare-Associated Infections in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-98122-2_12

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