Advertisement

Lamellar Ichthyosis

  • Tor Shwayder
  • Samantha L. Schneider
  • Devika Icecreamwala
  • Marla N. Jahnke
Chapter
  • 219 Downloads

Abstract

Lamellar ichthyosis is a sub-type of non-bullous congenital ichthyosis. It can also be classified as one of the non-syndromic autosomal recessive congenital ichthyosis (ARCI) clinical manifestations [1]. Other ichthyoses within ARCI include congenital ichthyosiform erythroderma and harlequin ichthyosis. Many genes have been implicated in the pathogenesis of lamellar ichthyosis including ABCA12, ALOXE3, ALOX12B, CERS3, CYP4F22, NIPAL4/ICHTHYIN, PNPLA1, and TGM1 [2]. The most common mutations include TGM1 and ABCA12. Lamellar ichthyosis is uncommon occurring in 1 in 200,000 to 1 in 300,000 live births worldwide; however, it is more common in certain populations [1].

References

  1. 1.
    Takeichi T, Akiyama M. Inherited ichthyosis: non-syndromic forms. J Dermatol. 2016;43(3):242–51.CrossRefGoogle Scholar
  2. 2.
    Glick JB, Craiglow BG, Choate KA, Kato H, Fleming RE, Siegfried E, Glick SA. Improved management of harlequin ichthyosis with advances in neonatal intensive care. Pediatrics. 2017;139(1). pii: e20161003. https://doi.org/10.1542/peds.2016-1003. Epub 2016 Dec 20. Review. PMID: 27999114.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tor Shwayder
    • 1
  • Samantha L. Schneider
    • 2
  • Devika Icecreamwala
    • 3
  • Marla N. Jahnke
    • 2
  1. 1.Pediatric DermatologyHenry Ford HospitalDetroitUSA
  2. 2.Department of DermatologyHenry Ford HospitalDetroitUSA
  3. 3.Icecreamwala DermatologyBerkeleyUSA

Personalised recommendations