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Junctional Epidermolysis Bullosa

  • Tor Shwayder
  • Samantha L. Schneider
  • Devika Icecreamwala
  • Marla N. Jahnke
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Abstract

Junctional epidermolysis bullosa (JEB) induces skin fragility slightly deeper in the basement membrane zone affecting the lamina lucida. It is most commonly inherited in an autosomal recessive manner. Mutations include LAMA3, LAMB3, LAMC2, COL17A1, ITGA6, ITGB4 corresponding to the proteins laminin-332, type XVII collagen, and alpha-6 beta-4 integrin.

Reference

  1. 1.
    Intong LR, Murrell DF. Inherited epidermolysis bullosa: new diagnostic criteria and classification. Clin Dermatol. 2012;30(1):70–7.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tor Shwayder
    • 1
  • Samantha L. Schneider
    • 2
  • Devika Icecreamwala
    • 3
  • Marla N. Jahnke
    • 2
  1. 1.Pediatric DermatologyHenry Ford HospitalDetroitUSA
  2. 2.Department of DermatologyHenry Ford HospitalDetroitUSA
  3. 3.Icecreamwala DermatologyBerkeleyUSA

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