Abstract
Congenital hemolytic anemias are due to defects affecting the red cell membrane, red cell enzymes, hemoglobin structural properties, or hemoglobin synthesis. The clinical picture depends upon the severity of the defects, the duration of hemolysis, and the exposure to a hemolysis-precipitating or hemolysis-augmenting event and ranges from asymptomatic to life-threatening anemia. Even fully compensated non-anemic congenital hemolytic conditions increase the risk of gallstones and erythroferrone/hepcidin-mediated iron overload and its associated complications.
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Kaushansky K, Lichtman MA, Prchal JT, Levi M, Press OW, Burns LJ, Caligiuri MA, editors. Williams hematology. 9th ed. New York: McGraw Hill; 2015. ISBN 978-0-07-183300-4
Kaushansky K, Lichtman MA, Prchal JT, Levi M, Press OW, Burns LJ, Caligiuri MA, editors. Williams manual of hematology. 9th ed. New York: McGraw Hill; 2016. ISBN 978-1-259-64247-0
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Gregg, X., Agarwal, A., Prchal, J.T. (2019). Congenital Hemolytic Anemias. In: Lazarus, H., Schmaier, A. (eds) Concise Guide to Hematology. Springer, Cham. https://doi.org/10.1007/978-3-319-97873-4_8
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DOI: https://doi.org/10.1007/978-3-319-97873-4_8
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