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Vestibular Migraine

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Diagnosis and Treatment of Vestibular Disorders

Abstract

Vestibular migraine is a clinical syndrome of the central nervous system that is characterized by episodic vestibular symptoms and a history of migraines. It affects approximately 1% of the population [1] and is one of the most common diagnoses in children presenting with vertigo [2].

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References

  1. Neuhauser HK, Radtke A, von Brevern M, Feldmann M, Lezius F, Ziese T, et al. Migrainous vertigo: prevalence and impact on quality of life. Neurology. 2006;67(6):1028–33.

    Article  CAS  PubMed  Google Scholar 

  2. Lee JD, Kim CH, Hong SM, Kim SH, Suh MW, Kim MB, et al. Prevalence of vestibular and balance disorders in children and adolescents according to age: a multi-center study. Int J Pediatr Otorhinolaryngol. 2017;94:36–9.

    Article  PubMed  Google Scholar 

  3. Huppert D, Brandt T. Descriptions of vestibular migraine and Meniere’s disease in Greek and Chinese antiquity. Cephalalgia. 2017;37(4):385–90.

    Article  PubMed  Google Scholar 

  4. Escat H. De la migraine otique. VII Congrés International d’Otologie Bordeaux: Gounouillhon. 1904;1176.

    Google Scholar 

  5. Liveing E. On megrim, sick-headache, and some allied disorders: a contribution to the pathology of nerve-storms. London: Churchill; 1873.

    Google Scholar 

  6. Boenheim F. Über familiäre Hemicrania vestibularis. Neurol Centralbl. 1917;36:226–9.

    Google Scholar 

  7. Slater R. Benign recurrent vertigo. J Neurol Neurosurg Psychiatry. 1979;42(4):363–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kayan A, Hood JD. Neuro-otological manifestations of migraine. Brain. 1984;107(Pt 4):1123–42.

    Article  PubMed  Google Scholar 

  9. Dieterich M, Brandt T. Episodic vertigo related to migraine (90 cases): vestibular migraine? J Neurol. 1999;246(10):883–92.

    Article  CAS  PubMed  Google Scholar 

  10. Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, et al. Vestibular migraine: diagnostic criteria. J Vestib Res. 2012;22(4):167–72.

    PubMed  Google Scholar 

  11. Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T. The interrelations of migraine, vertigo, and migrainous vertigo. Neurology. 2001;56(4):436–41.

    Article  CAS  PubMed  Google Scholar 

  12. Vukovic V, Plavec D, Galinovic I, Lovrencic-Huzjan A, Budisic M, Demarin V. Prevalence of vertigo, dizziness, and migrainous vertigo in patients with migraine. Headache. 2007;47(10):1427–35.

    Article  PubMed  Google Scholar 

  13. Yollu U, Uluduz DU, Yilmaz M, Yener HM, Akil F, Kuzu B, et al. Vestibular migraine screening in a migraine-diagnosed patient population, and assessment of vestibulocochlear function. Clin Otolaryngol. 2017;42(2):225–33.

    Article  CAS  PubMed  Google Scholar 

  14. Batu ED, Anlar B, Topcu M, Turanli G, Aysun S. Vertigo in childhood: a retrospective series of 100 children. Eur J Paediatr Neurol. 2015;19(2):226–32.

    Article  PubMed  Google Scholar 

  15. Jahn K, Langhagen T, Heinen F. Vertigo and dizziness in children. Curr Opin Neurol. 2015;28(1):78–82.

    Article  PubMed  Google Scholar 

  16. Geser R, Straumann D. Referral and final diagnoses of patients assessed in an academic vertigo center. Front Neurol. 2012;3:169.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Zamergrad MV, Parfenov VA, Yakhno NN, Melnikov OA, Antonenko LM, Nefedovskaya LV, et al. Common causes of vertigo and dizziness in different age groups of patients. Bionanoscience. 2017;7(2):259–62.

    Article  Google Scholar 

  18. Colombo B, Teggi R. Vestibular migraine: who is the patient? Neurol Sci. 2017;38:107–10.

    Article  PubMed  Google Scholar 

  19. Van Ombergen A, Van Rompaey V, Van de Heyning P, Wuyts F. Vestibular migraine in an otolaryngology clinic: prevalence, associated symptoms, and prophylactic medication effectiveness. Otol Neurotol. 2015;36(1):133–8.

    PubMed  Google Scholar 

  20. Park JH, Viirre E. Vestibular migraine may be an important cause of dizziness/vertigo in perimenopausal period. Med Hypotheses. 2010;75(5):409–14.

    Article  CAS  PubMed  Google Scholar 

  21. Abu-Arafeh I, Russell G. Paroxysmal vertigo as a migraine equivalent in children: a population-based study. Cephalalgia. 1995;15(1):22–5; discussion 4.

    Article  CAS  PubMed  Google Scholar 

  22. Johnson GD. Medical management of migraine-related dizziness and vertigo. Laryngoscope. 1998;108(1 Pt 2):1–28.

    Article  CAS  PubMed  Google Scholar 

  23. Zhang Y, Kong Q, Chen J, Li L, Wang D, Zhou J. International classification of headache disorders 3rd edition beta-based field testing of vestibular migraine in China: demographic, clinical characteristics, audiometric findings and diagnosis statues. Cephalalgia. 2016;36(3):240–8.

    Article  PubMed  Google Scholar 

  24. Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF, et al. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007;68(5):343–9.

    Article  CAS  PubMed  Google Scholar 

  25. Nakashima K, Yokoyama Y, Shimoyama R, Saito H, Kuno N, Sano K, et al. Prevalence of neurological disorders in a Japanese town. Neuroepidemiology. 1996;15(4):208–13.

    Article  CAS  PubMed  Google Scholar 

  26. Sloane PD. Dizziness in primary care. Results from the National Ambulatory Medical Care Survey. J Fam Pract. 1989;29(1):33–8.

    CAS  PubMed  Google Scholar 

  27. Neuhauser HK, von Brevern M, Radtke A, Lezius F, Feldmann M, Ziese T, et al. Epidemiology of vestibular vertigo: a neurotologic survey of the general population. Neurology. 2005;65(6):898–904.

    Article  CAS  PubMed  Google Scholar 

  28. Murdin L, Schilder AGM. Epidemiology of balance symptoms and disorders in the community: a systematic review. Otol Neurotol. 2015;36(3):387–92.

    Article  PubMed  Google Scholar 

  29. Kroenke K, Lucas CA, Rosenberg ML, Scherokman BJ. Psychiatric disorders and functional impairment in patients with persistent dizziness. J Gen Intern Med. 1993;8(10):530–5.

    Article  CAS  PubMed  Google Scholar 

  30. Aragones JM, Fortes-Rego J, Fuste J, Cardozo A. Migraine: an alternative in the diagnosis of unclassified vertigo. Headache. 1993;33(3):125–8.

    Article  CAS  PubMed  Google Scholar 

  31. Savundra PA, Carroll JD, Davies RA, Luxon LM. Migraine-associated vertigo. Cephalalgia. 1997;17(4):505–10; discussion 487.

    Article  CAS  PubMed  Google Scholar 

  32. Furman JM, Marcus DA, Balaban CD. Vestibular migraine: clinical aspects and pathophysiology. Lancet Neurol. 2013;12(7):706–15.

    Article  CAS  PubMed  Google Scholar 

  33. Eggers SDZ, Neff BA, Shepard NT, Staab JP. Comorbidities in vestibular migraine. J Vestib Res Equilib Orientat. 2014;24(5–6):387–95.

    Google Scholar 

  34. Muelleman T, Shew M, Subbarayan R, Shum A, Sykes K, Staecker H, et al. Epidemiology of dizzy patient population in a neurotology clinic and predictors of peripheral etiology. Otol Neurotol. 2017;38(6):870–5.

    Article  PubMed  Google Scholar 

  35. Tungvachirakul V, Lisnichuk H, O’Leary SJ. Epidemiology of vestibular vertigo in a neuro-otology clinic population in Thailand. J Laryngol Otol. 2014;128(Suppl 2):S31–8.

    Article  PubMed  Google Scholar 

  36. Eggers SD, Staab JP, Neff BA, Goulson AM, Carlson ML, Shepard NT. Investigation of the coherence of definite and probable vestibular migraine as distinct clinical entities. Otol Neurotol. 2011;32(7):1144–51.

    Article  PubMed  Google Scholar 

  37. Gurkov R, Kantner C, Strupp M, Flatz W, Krause E, Ertl-Wagner B. Endolymphatic hydrops in patients with vestibular migraine and auditory symptoms. Eur Arch Otorhinolaryngol. 2014;271(10):2661–7.

    Article  PubMed  Google Scholar 

  38. Neff BA, Staab JP, Eggers SD, Carlson ML, Schmitt WR, Van Abel KM, et al. Auditory and vestibular symptoms and chronic subjective dizziness in patients with Meniere’s disease, vestibular migraine, and Meniere’s disease with concomitant vestibular migraine. Otol Neurotol. 2012;33(7):1235–44.

    Article  PubMed  Google Scholar 

  39. Dieterich M, Staab JP. Functional dizziness: from phobic postural vertigo and chronic subjective dizziness to persistent postural-perceptual dizziness. Curr Opin Neurol. 2017;30(1):107–13.

    Article  PubMed  Google Scholar 

  40. von Brevern M, Zeise D, Neuhauser H, Clarke AH, Lempert T. Acute migrainous vertigo: clinical and oculographic findings. Brain. 2005;128(Pt 2):365–74.

    Google Scholar 

  41. Polensek SH, Tusa RJ. Nystagmus during attacks of vestibular migraine: an aid in diagnosis. Audiol Neurootol. 2010;15(4):241–6.

    Article  PubMed  Google Scholar 

  42. Espinosa-Sanchez JM, Lopez-Escamez JA. New insights into pathophysiology of vestibular migraine. Front Neurol. 2015;6:6.

    Article  Google Scholar 

  43. Goadsby P, Charbit A, Andreou A, Akerman S, Holland P. Neurobiology of migraine. Neuroscience. 2009;161(2):327–41.

    Article  CAS  PubMed  Google Scholar 

  44. Pietrobon D, Moskowitz MA. Pathophysiology of migraine. Annu Rev Physiol. 2013;75:365–91.

    Article  CAS  PubMed  Google Scholar 

  45. Karatas H, Erdener SE, Gursoy-Ozdemir Y, Lule S, Eren-Koçak E, Sen ZD, et al. Spreading depression triggers headache by activating neuronal Panx1 channels. Science. 2013;339(6123):1092–5.

    Article  CAS  PubMed  Google Scholar 

  46. Baloh RW. Neurotology of migraine. Headache. 1997;37(10):615–21.

    Article  CAS  PubMed  Google Scholar 

  47. Kruit MC, van Buchem MA, Launer LJ, Terwindt GM, Ferrari MD. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: The population-based MRI CAMERA-study. Cephalalgia: an international journal of headache. 2010;30(2):129–136. https://doi.org/:10.1111/j.1468-2982.2009.01904.x.

    Article  Google Scholar 

  48. Guidetti D, Rota E, Morelli N, Immovilli P. Migraine and stroke: “vascular” comorbidity. Front Neurol. 2014;5:193.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Baloh RW, Jacobson K, Fife T. Familial vestibulopathy: a new dominantly inherited syndrome. Neurology. 1994;44(1):20–5.

    Article  CAS  PubMed  Google Scholar 

  50. Baloh RW, Foster CA, Yue Q, Nelson SF. Familial migraine with vertigo and essential tremor. Neurology. 1996;46(2):458–60.

    Article  CAS  PubMed  Google Scholar 

  51. Oh AK, Lee H, Jen JC, Corona S, Jacobson KM, Baloh RW. Familial benign recurrent vertigo. Am J Med Genet. 2001;100(4):287–91.

    Article  CAS  PubMed  Google Scholar 

  52. Lee H, Jen JC, Wang H, Chen Z, Mamsa H, Sabatti C, et al. A genome-wide linkage scan of familial benign recurrent vertigo: linkage to 22q12 with evidence of heterogeneity. Hum Mol Genet. 2006;15(2):251–8.

    Article  CAS  PubMed  Google Scholar 

  53. Jen JC, Wang H, Lee H, Sabatti C, Trent R, Hannigan I, et al. Suggestive linkage to chromosome 6q in families with bilateral vestibulopathy. Neurology. 2004;63(12):2376–9.

    Article  CAS  PubMed  Google Scholar 

  54. Lee H, Jen JC, Cha YH, Nelson SF, Baloh RW. Phenotypic and genetic analysis of a large family with migraine-associated vertigo. Headache. 2008;48(10):1460–7.

    Article  PubMed  Google Scholar 

  55. Bahmad F Jr, DePalma SR, Merchant SN, Bezerra RL, Oliveira CA, Seidman CE, et al. Locus for familial migrainous vertigo disease maps to chromosome 5q35. Ann Otol Rhinol Laryngol. 2009;118(9):670–6.

    Article  PubMed  PubMed Central  Google Scholar 

  56. De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L, et al. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. 2003;33(2):192–6.

    Article  PubMed  CAS  Google Scholar 

  57. Requena T, Espinosa-Sanchez JM, Lopez-Escamez JA. Genetics of dizziness: cerebellar and vestibular disorders. Curr Opin Neurol. 2014;27(1):98–104.

    Article  PubMed  Google Scholar 

  58. Pietrobon D. Calcium channels and migraine. Biochim Biophys Acta Biomembr. 2013;1828(7):1655–65.

    Article  CAS  Google Scholar 

  59. Dichgans M, Freilinger T, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet. 2005;366(9483):371–7.

    Article  CAS  PubMed  Google Scholar 

  60. Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell. 1996;87(3):543–52.

    Article  CAS  PubMed  Google Scholar 

  61. Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, et al. Corrigendum: meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet. 2016;48(10):1296.

    Article  CAS  PubMed  Google Scholar 

  62. Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, et al. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet. 2016;48(8):856–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Lopez C, Blanke O. The thalamocortical vestibular system in animals and humans. Brain Res Rev. 2011;67(1):119–46.

    Article  PubMed  Google Scholar 

  64. Russo A, Marcelli V, Esposito F, Corvino V, Marcuccio L, Giannone A, et al. Abnormal thalamic function in patients with vestibular migraine. Neurology. 2014;82(23):2120–6.

    Article  PubMed  Google Scholar 

  65. Shin JH, Kim YK, Kim HJ, Kim JS. Altered brain metabolism in vestibular migraine: comparison of interictal and ictal findings. Cephalalgia. 2014;34(1):58–67.

    Article  PubMed  Google Scholar 

  66. Baier B, Eulenburg PZ, Best C, Geber C, Müller-Forell W, Birklein F, et al. Posterior insular cortex–a site of vestibular–somatosensory interaction? Brain Behav. 2013;3(5):519–24.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Garcia-Larrea L. The posterior insular-opercular region and the search of a primary cortex for pain. Neurophysiol Clin. 2012;42(5):299–313.

    Article  CAS  PubMed  Google Scholar 

  68. Zu Eulenburg P, Baumgärtner U, Treede R-D, Dieterich M. Interoceptive and multimodal functions of the operculo-insular cortex: tactile, nociceptive and vestibular representations. NeuroImage. 2013;83:75–86.

    Article  CAS  PubMed  Google Scholar 

  69. Brandt T, Bartenstein P, Janek A, Dieterich M. Reciprocal inhibitory visual-vestibular interaction. Visual motion stimulation deactivates the parieto-insular vestibular cortex. Brain J Neurol. 1998;121(9):1749–58.

    Article  Google Scholar 

  70. Russo A, Marcuccio L, Conte F, Caiazzo G, Giordano A, Conforti R, et al. No evidence of microstructural changes in patients with vestibular migraine: a diffusion tensor tract based spatial statistic (TBSS) study. J Headache Pain. 2015;16:2.

    Article  Google Scholar 

  71. Obermann M, Wurthmann S, Steinberg BS, Theysohn N, Diener HC, Naegel S. Central vestibular system modulation in vestibular migraine. Cephalalgia. 2014;34(13):1053–61.

    Article  PubMed  Google Scholar 

  72. Messina R, Rocca MA, Colombo B, Teggi R, Falini A, Comi G, et al. Structural brain abnormalities in patients with vestibular migraine. J Neurol. 2017;264(2):295–303.

    Article  PubMed  Google Scholar 

  73. Moretti G, Manzoni GC, Caffarra P, Parma M. “Benign recurrent vertigo” and its connection with migraine. Headache. 1980;20(6):344–6.

    Article  CAS  PubMed  Google Scholar 

  74. Stolte B, Holle D, Naegel S, Diener HC, Obermann M. Vestibular migraine. Cephalalgia. 2015;35(3):262–70.

    Article  PubMed  Google Scholar 

  75. von Brevern M, Lempert T. Vestibular migraine. Hand. 2016;137:301–16.

    Google Scholar 

  76. Kuritzky A, Ziegler DK, Hassanein R. Vertigo, motion sickness and migraine. Headache. 1981;21(5):227–31.

    Article  CAS  PubMed  Google Scholar 

  77. Cass SP, Furman JM, Ankerstjerne K, Balaban C, Yetiser S, Aydogan B. Migraine-related vestibulopathy. Ann Otol Rhinol Laryngol. 1997;106(3):182–9.

    Article  CAS  PubMed  Google Scholar 

  78. Waterston J. Chronic migrainous vertigo. J Clin Neurosci. 2004;11(4):384–8.

    Article  PubMed  Google Scholar 

  79. Radtke A, von Brevern M, Neuhauser H, Hottenrott T, Lempert T. Vestibular migraine: long-term follow-up of clinical symptoms and vestibulo-cochlear findings. Neurology. 2012;79(15):1607–14.

    Article  PubMed  Google Scholar 

  80. Cutrer FM, Baloh RW. Migraine-associated dizziness. Headache. 1992;32(6):300–4.

    Article  CAS  PubMed  Google Scholar 

  81. Headache Classification Subcommittee of the International Headache S. The international classification of headache disorders: 2nd edition. Cephalalgia. 2004;24(Suppl 1):9–160.

    Google Scholar 

  82. Behan PO, Carlin J. Benign recurrent vertigo. In: Advances in migraine research and therapy. New York: Raven; 1982. p. 49–55.

    Google Scholar 

  83. Neuhauser H, Lempert T. Vertigo and dizziness related to migraine: a diagnostic challenge. Cephalalgia. 2004;24(2):83–91.

    Article  CAS  PubMed  Google Scholar 

  84. Parker W. Migraine and the vestibular system in adults. Am J Otol. 1991;12(1):25–34.

    CAS  PubMed  Google Scholar 

  85. Olsson JE. Neurotologic findings in basilar migraine. Laryngoscope. 1991;101(1):1–41.

    Article  CAS  PubMed  Google Scholar 

  86. Best C, Eckhardt-Henn A, Tschan R, Dieterich M. Psychiatric morbidity and comorbidity in different vestibular vertigo syndromes. Results of a prospective longitudinal study over one year. J Neurol. 2009;256(1):58–65.

    Article  PubMed  Google Scholar 

  87. Best C, Tschan R, Eckhardt-Henn A, Dieterich M. Who is at risk for ongoing dizziness and psychological strain after a vestibular disorder? Neuroscience. 2009;164(4):1579–87.

    Article  CAS  PubMed  Google Scholar 

  88. Staab JP. Behavioural neuro-otology. In: Oxford textbook of vertigo and imbalance. Oxford: Oxford University Press; 2013. p. 333.

    Chapter  Google Scholar 

  89. Kroenke K, Lucas CA, Rosenberg ML, Scherokman B, Herbers JE Jr, Wehrle PA, et al. Causes of persistent dizziness. A prospective study of 100 patients in ambulatory care. Ann Intern Med. 1992;117(11):898–904.

    Article  CAS  PubMed  Google Scholar 

  90. Post RE, Dickerson LM. Dizziness: a diagnostic approach. Am Fam Physician. 2010;82(4):361–8, 9.

    Google Scholar 

  91. Burch RC, Loder S, Loder E, Smitherman TA. The prevalence and burden of migraine and severe headache in the United States: updated statistics from government health surveillance studies. Headache. 2015;55(1):21–34.

    Article  PubMed  Google Scholar 

  92. Ricci F, De Caterina R, Fedorowski A. Orthostatic hypotension: epidemiology, prognosis, and treatment. J Am Coll Cardiol. 2015;66(7):848–60.

    Article  PubMed  Google Scholar 

  93. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003;163(22):2716–24.

    Article  PubMed  Google Scholar 

  94. Harris JP, Alexander TH. Current-day prevalence of Meniere’s syndrome. Audiol Neurootol. 2010;15(5):318–22.

    Article  PubMed  Google Scholar 

  95. von Brevern M, Radtke A, Lezius F, Feldmann M, Ziese T, Lempert T, et al. Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry. 2007;78(7):710–5.

    Article  Google Scholar 

  96. Gannon RP, Willson GN, Roberts ME, Pearse HJ. Auditory and vestibular damage in head injuries at work. Arch Otolaryngol. 1978;104(7):404–8.

    Article  CAS  PubMed  Google Scholar 

  97. Kolev OI, Sergeeva M. Vestibular disorders following different types of head and neck trauma. Funct Neurol. 2016;31(2):75–80.

    PubMed  PubMed Central  Google Scholar 

  98. Lucas S. Posttraumatic headache: clinical characterization and management. Curr Pain Headache Rep. 2015;19(10):48.

    Article  PubMed  Google Scholar 

  99. Lucas S. Characterization and management of headache after mild traumatic brain injury. In: Kobeissy FH, editor. Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects. Frontiers in neuroengineering. Boca Raton: CRC Press; 2015.

    Chapter  Google Scholar 

  100. Kim SK, Lee KJ, Hahm JR, Lee SM, Jung TS, Jung JH, et al. Clinical significance of the presence of autonomic and vestibular dysfunction in diabetic patients with peripheral neuropathy. Diabetes Metab J. 2012;36(1):64–9.

    Article  PubMed  PubMed Central  Google Scholar 

  101. Alpini D, Caputo D, Pugnetti L, Giuliano DA, Cesarani A. Vertigo and multiple sclerosis: aspects of differential diagnosis. Neurol Sci. 2001;22(Suppl 2):S84–7.

    Article  PubMed  Google Scholar 

  102. Strupp M, Brandt T. Vestibular neuritis. Semin Neurol. 2009;29(5):509–19.

    Article  PubMed  Google Scholar 

  103. Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE. HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke. 2009;40(11):3504–10.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Foley RW, Shirazi S, Maweni RM, Walsh K, McConn Walsh R, Javadpour M, et al. Signs and symptoms of acoustic neuroma at initial presentation: an exploratory analysis. Cureus. 2017;9(11):e1846.

    PubMed  PubMed Central  Google Scholar 

  105. Tarnutzer AA, Lee SH, Robinson KA, Kaplan PW, Newman-Toker DE. Clinical and electrographic findings in epileptic vertigo and dizziness: a systematic review. Neurology. 2015;84(15):1595–604.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Maldonado FM, Birdi JS, Irving GJ, Murdin L, Kivekäs I, Strupp M. Pharmacological agents for the prevention of vestibular migraine. Cochrane Database Syst Rev [Internet]. 2015;(6). Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010600.pub2/abstract, http://onlinelibrary.wiley.com/store/10.1002/14651858.CD010600.pub2/asset/CD010600.pdf?v=1&t=j8umolu7&s=1d8aa1ff72cb0e4cb10902e7c6727f8850d99717.

  107. Neuhauser H, Lempert T. Vestibular migraine. Neurol Clin. 2009;27(2):379–91.

    Article  PubMed  Google Scholar 

  108. Reploeg MD, Goebel JA. Migraine-associated dizziness: patient characteristics and management options. Otol Neurotol. 2002;23(3):364–71.

    Article  PubMed  Google Scholar 

  109. Mikulec AA, Faraji F, Kinsella LJ. Evaluation of the efficacy of caffeine cessation, nortriptyline, and topiramate therapy in vestibular migraine and complex dizziness of unknown etiology. Am J Otolaryngol. 2012;33(1):121–7.

    Article  CAS  PubMed  Google Scholar 

  110. Whitney SL, Wrisley DM, Brown KE, Furman JM. Physical therapy for migraine-related vestibulopathy and vestibular dysfunction with history of migraine. Laryngoscope. 2000;110(9):1528–34.

    Article  CAS  PubMed  Google Scholar 

  111. Wrisley DM, Whitney SL, Furman JM. Vestibular rehabilitation outcomes in patients with a history of migraine. Otol Neurotol. 2002;23(4):483–7.

    Article  PubMed  Google Scholar 

  112. Vitkovic J, Winoto A, Rance G, Dowell R, Paine M. Vestibular rehabilitation outcomes in patients with and without vestibular migraine. J Neurol. 2013;260(12):3039–48.

    Article  PubMed  Google Scholar 

  113. Whitney SL, Sparto PJ. Principles of vestibular physical therapy rehabilitation. NeuroRehabilitation. 2011;29(2):157–66.

    PubMed  PubMed Central  Google Scholar 

  114. Staab JP. Chronic dizziness: the interface between psychiatry and neuro-otology. Curr Opin Neurol. 2006;19(1):41–8.

    Article  PubMed  Google Scholar 

  115. Neuhauser H, Radtke A, von Brevern M, Lempert T. Zolmitriptan for treatment of migrainous vertigo: a pilot randomized placebo-controlled trial. Neurology. 2003;60(5):882–3.

    Article  CAS  PubMed  Google Scholar 

  116. Bikhazi P, Jackson C, Ruckenstein MJ. Efficacy of antimigrainous therapy in the treatment of migraine-associated dizziness. Am J Otol. 1997;18(3):350–4.

    CAS  PubMed  Google Scholar 

  117. Cassano D, Pizza V, Busillo V. Almotriptan in the acute treatment of Vestibular migraine: a retrospective study. J Headache Pain. 2015;16:2.

    Article  Google Scholar 

  118. Prakash S, Chavda BV, Mandalia H, Dhawan R, Padmanabhan D. Headaches related to triptans therapy in patients of migrainous vertigo. J Headache Pain. 2008;9(3):185–8.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Marcus DA, Furman JM. Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study. Med Sci Monit. 2006;12(1):PI1–7.

    CAS  PubMed  Google Scholar 

  120. Prakash S, Shah ND. Migrainous vertigo responsive to intravenous methylprednisolone: case reports. Headache. 2009;49(8):1235–9.

    Article  PubMed  Google Scholar 

  121. Strupp M, Dieterich M, Brandt T. The treatment and natural course of peripheral and central vertigo. Dtsch Arztebl Int. 2013;110(29–30):505–15; quiz 15–6.

    Google Scholar 

  122. Seemungal B, Kaski D, Lopez-Escamez JA. Early diagnosis and management of acute vertigo from vestibular migraine and Meniere’s disease. Neurol Clin. 2015;33(3):619–28, ix.

    Article  PubMed  Google Scholar 

  123. Jackson JL, Cogbill E, Santana-Davila R, Eldredge C, Collier W, Gradall A, et al. A comparative effectiveness meta-analysis of drugs for the prophylaxis of migraine headache. PLoS One. 2015;10(7):e0130733.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  124. Sanchez-Del-Rio M, Reuter U, Moskowitz MA. New insights into migraine pathophysiology. Curr Opin Neurol. 2006;19(3):294–8.

    Article  CAS  PubMed  Google Scholar 

  125. Eggers SD. Migraine-related vertigo: diagnosis and treatment. Curr Pain Headache Rep. 2007;11(3):217–26.

    Article  PubMed  Google Scholar 

  126. Salmito MC, Duarte JA, Morganti LOG, Brandao PVC, Nakao BH, Villa TR, et al. Prophylactic treatment of vestibular migraine. Braz J Otorhinolaryngol. 2017;83(4):404–10.

    Article  PubMed  Google Scholar 

  127. Salviz M, Yuce T, Acar H, Karatas A, Acikalin RM. Propranolol and venlafaxine for vestibular migraine prophylaxis: a randomized controlled trial. Laryngoscope. 2016;126(1):169–74.

    Article  CAS  PubMed  Google Scholar 

  128. Maione A. Migraine-related vertigo: diagnostic criteria and prophylactic treatment. Laryngoscope. 2006;116(10):1782–6.

    Article  PubMed  Google Scholar 

  129. Silberstein SD. Preventive treatment of migraine: an overview. Cephalalgia. 1997;17(2):67–72.

    Article  CAS  PubMed  Google Scholar 

  130. Lepcha A, Amalanathan S, Augustine AM, Tyagi AK, Balraj A. Flunarizine in the prophylaxis of migrainous vertigo: a randomized controlled trial. Eur Arch Otorhinolaryngol. 2014;271(11):2931–6.

    Article  PubMed  Google Scholar 

  131. Visvanathan N, Kannaian S, Nimmakayala R. Flunarizine for the prophylaxis of vestibular migraine. Neurology Conference: 69th American Academy of Neurology Annual Meeting, AAN. 2017;88(16 Suppl. 1).

    Google Scholar 

  132. Peer Mohamed B, Goadsby PJ, Prabhakar P. Safety and efficacy of flunarizine in childhood migraine: 11 years’ experience, with emphasis on its effect in hemiplegic migraine. Dev Med Child Neurol. 2012;54(3):274–7.

    Article  PubMed  Google Scholar 

  133. Sanvito WL, Oliveira BC. Prophylactic treatment of migraine: a prospective open study on 100 patients. Arq Neuropsiquiatr. 1993;51(1):31–5.

    Article  CAS  PubMed  Google Scholar 

  134. Gordon CR, Shupak A. Prevention and treatment of motion sickness in children. CNS Drugs. 1999;12(5):369–81.

    Article  CAS  Google Scholar 

  135. Taghdiri F, Togha M, Jahromi SR, Refaeian F. Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. Springerplus. 2014;3:5.

    Article  CAS  Google Scholar 

  136. Teggi R, Colombo B, Gatti O, Comi G, Bussi M. Fixed combination of cinnarizine and dimenhydrinate in the prophylactic therapy of vestibular migraine: an observational study. Neurol Sci. 2015;36(10):1869–73.

    Article  CAS  PubMed  Google Scholar 

  137. Brodsky JR, Cusick BA, Zhou G. Evaluation and management of vestibular migraine in children: experience from a pediatric vestibular clinic. Eur J Paediatr Neurol. 2016;20(1):85–92.

    Article  PubMed  Google Scholar 

  138. Staab JP, Eggers SD, Neff BA, Shepard NT. Vestibular migraine and persistent postural-perceptual dizziness: results of a double blind, parallel group, pharmacologic dissection trial using verapamil and sertraline. Cephalalgia. 2015;35:65.

    Google Scholar 

  139. Frommer DA, Kulig KW, Marx JA, Rumack B. Tricyclic antidepressant overdose. A review. JAMA. 1987;257(4):521–6.

    Article  CAS  PubMed  Google Scholar 

  140. Walker Z, Walker RW, Robertson MM, Stansfeld S. Antidepressant treatment of chronic tension-type headache: a comparison between fluoxetine and desipramine. Headache. 1998;38(7):523–8.

    Article  CAS  PubMed  Google Scholar 

  141. Kacperski J, Kabbouche MA, O’Brien HL, Weberding JL. The optimal management of headaches in children and adolescents. Ther Adv Neurol Disord. 2016;9(1):53–68.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  142. Linde M, Mulleners WM, Chronicle EP, McCrory DC. Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults. Cochrane Libr. 2013. 6):CD010610

    Google Scholar 

  143. Silberstein SD. Preventive migraine treatment. Continuum (Minneap Minn). 2015;21(4 Headache):973–89.

    Google Scholar 

  144. Bisdorff AR. Management of vestibular migraine. Ther Adv Neurol Disord. 2011;4(3):183–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  145. Celebisoy N, Gokcay F, Karahan C, Bilgen C, Kirazli T, Karapolat H, et al. Acetazolamide in vestibular migraine prophylaxis: a retrospective study. Eur Arch Otorhinolaryngol [Internet]. 2016;273(10):2947–51. Available from: http://onlinelibrary.wiley.com/o/cochrane/clcentral/articles/193/CN-01208193/frame.html, https://link.springer.com/content/pdf/10.1007%2Fs00405-015-3874-4.pdf.

    Article  PubMed  Google Scholar 

  146. Baloh RW, Winder A. Acetazolamide-responsive vestibulocerebellar syndrome: clinical and oculographic features. Neurology. 1991;41(3):429–33.

    Article  CAS  PubMed  Google Scholar 

  147. Griggs RC, Moxley RT, Lafrance RA, McQuillen J. Hereditary paroxysmal ataxia response to acetazolamide. Neurology. 1978;28(12):1259.

    Article  CAS  PubMed  Google Scholar 

  148. Shirai T, Meyer J, Akiyama H, Mortel K, Wills P. Acetazolamide testing of cerebral vasodilator capacity provokes “vascular” but not tension headaches. Headache J Head Face Pain. 1996;36(10):589–94.

    Article  CAS  Google Scholar 

  149. Carmona S, Settecase N. Use of topiramate (topamax) in a subgroup of migraine-vertigo patients with auditory symptoms. Ann N Y Acad Sci. 2005;1039:517–20.

    Article  CAS  PubMed  Google Scholar 

  150. Baier B, Winkenwerder E, Dieterich M. “Vestibular migraine”: effects of prophylactic therapy with various drugs. A retrospective study. J Neurol. 2009;256(3):436–42.

    Article  PubMed  Google Scholar 

  151. Gode S, Celebisoy N, Kirazli T, Akyuz A, Bilgen C, Karapolat H, et al. Clinical assessment of topiramate therapy in patients with migrainous vertigo. Headache. 2010;50(1):77–84.

    Article  PubMed  Google Scholar 

  152. Cologno D, d’Onofrio F, Castriota O, Petretta V, Casucci G, Russo A, et al. Basilar-type migraine patients responsive to lamotrigine: a 5-year follow-up. Neurol Sci. 2013;34(Suppl 1):S165–6.

    Article  PubMed  Google Scholar 

  153. Bisdorff AR. Treatment of migraine related vertigo with lamotrigine an observational study. Bull Soc Sci Med Grand Duche Luxemb. 2004;2:103–8.

    Google Scholar 

  154. Gordon C, Kuritzky A, Doweck I, Spitzer O, Shupak A, Hering R. Vestibulo-ocular reflex in migraine patients: the effect of sodium valproate. Headache [Internet]. 1993;33(3):129–32. Available from: http://onlinelibrary.wiley.com/o/cochrane/clcentral/articles/935/CN-00092935/frame.html.

    Article  CAS  Google Scholar 

  155. Diener H, Pfaffenrath V, Schnitker J, Friede M, Henneicke-von ZH. Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention—a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia [Internet]. 2005;25(11):1031–41. Available from: http://onlinelibrary.wiley.com/o/cochrane/clcentral/articles/242/CN-00531242/frame.html.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Yale University, School of Medicine, New Haven, CT, USA

    Amy Schettino

  2. Departments of Neurology (OL,DN) Neuroscience (DN) and Surgery (DN), Yale University, School of Medicine, New Haven, CT, USA

    Dhasakumar Navaratnam

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  1. Amy Schettino
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Correspondence to Amy Schettino .

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Editors and Affiliations

  1. Department of Neurotology, Providence Hospital, Michigan Ear Institute, Farmington Hills, MI, USA

    Seilesh Babu

  2. Department of Neurotology, Providence Hospital, Michigan Ear Institute, Farmington Hills, MI, USA

    Christopher A. Schutt

  3. Department of Neurotology, Providence Hospital, Michigan Ear Institute, Farmington Hills, MI, USA

    Dennis I. Bojrab

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Schettino, A., Navaratnam, D. (2019). Vestibular Migraine. In: Babu, S., Schutt, C., Bojrab, D. (eds) Diagnosis and Treatment of Vestibular Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97858-1_18

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