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Case-Control Studies

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Case-control studies are a specialized type of observational study design ideally suited for evaluating rare diseases and those with a long latency period. Case-control studies begin by targeting people who have and do not have a disease or condition of interest and then work backward to determine associations with previous exposures. Due to the manner in which participants are selected for these studies, case-control data alone cannot be used to directly calculate the incidence of disease or incidence-based measures of risk. However, it is possible to estimate relative risk from case-control study data using the odds ratio.


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Kestenbaum, B. (2019). Case-Control Studies. In: Epidemiology and Biostatistics. Springer, Cham.

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-97432-3

  • Online ISBN: 978-3-319-97433-0

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