Case-Control Studies

  • Bryan Kestenbaum


Case-control studies are a specialized type of observational study design ideally suited for evaluating rare diseases and those with a long latency period. Case-control studies begin by targeting people who have and do not have a disease or condition of interest and then work backward to determine associations with previous exposures. Due to the manner in which participants are selected for these studies, case-control data alone cannot be used to directly calculate the incidence of disease or incidence-based measures of risk. However, it is possible to estimate relative risk from case-control study data using the odds ratio.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bryan Kestenbaum
    • 1
  1. 1.Division of Nephrology, Department of MedicineUniversity of WashingtonSeattleUSA

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