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Applications of Cardiac Extracellular Matrix in Tissue Engineering and Regenerative Medicine

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Cardiac Extracellular Matrix

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1098))

Abstract

The role of the cardiac extracellular matrix (cECM) in providing biophysical and biochemical cues to the cells housed within during disease and development has become increasingly apparent. These signals have been shown to influence many fundamental cardiac cell behaviors including contractility, proliferation, migration, and differentiation. Consequently, alterations to cell phenotype result in directed remodeling of the cECM. This bidirectional communication means that the cECM can be envisioned as a medium for information storage. As a result, the reprogramming of the cECM is increasingly being employed in tissue engineering and regenerative medicine as a method with which to treat disease. In this chapter, an overview of the composition and structure of the cECM as well as its role in cardiac development and disease will be provided. Additionally, therapeutic modulation of cECM for cardiac regeneration as well as bottom-up and top-down approaches to ECM-based cardiac tissue engineering is discussed. Finally, lingering questions regarding the role of cECM in tissue engineering and regenerative medicine are offered as a catalyst for future research.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Tufts University, Medford, MA, USA

    Mark C. Daley, Spencer L. Fenn & Lauren D. Black III

  2. Center for Biomedical Career Development, University of Massachusetts Medical School, Worcester, MA, USA

    Spencer L. Fenn

  3. Cellular, Molecular and Developmental Biology Program, Sackler School for Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA

    Lauren D. Black III

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  1. Mark C. Daley
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  2. Spencer L. Fenn
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Correspondence to Lauren D. Black III .

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Editors and Affiliations

  1. School of Medicine & Public Health, University of Wisconsin-Madison, Madison, WI, USA

    Eric G. Schmuck

  2. School of Medicine & Public Health, University of Wisconsin-Madison, Madison, WI, USA

    Peiman Hematti

  3. School of Medicine & Public Health, University of Wisconsin-Madison, Madison, WI, USA

    Amish N. Raval

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Daley, M.C., Fenn, S.L., Black, L.D. (2018). Applications of Cardiac Extracellular Matrix in Tissue Engineering and Regenerative Medicine. In: Schmuck, E., Hematti, P., Raval, A. (eds) Cardiac Extracellular Matrix. Advances in Experimental Medicine and Biology, vol 1098. Springer, Cham. https://doi.org/10.1007/978-3-319-97421-7_4

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