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Granulomatous Response to Mycobacterium tuberculosis Infection

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Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection

Abstract

Tuberculosis (TB) is a deadly infectious disease of humans caused by Mycobacterium tuberculosis (Mtb). In 2016, there were about 10 million new cases and 1.8 million deaths attributed to TB worldwide (WHO Report 2017). In addition, about a third of the world population has asymptomatic latent Mtb infection (LTBI), of which about 10% can reactivate to symptomatic active TB in their lifetime dependent upon their immune status. However, in a population, Mtb infection results in a heterogeneous outcome, ranging from complete bacterial clearance to the establishment of LTBI or development of a full-blown disease. A key feature of TB pathogenesis is granuloma formation, which has been a subject of intense research for several decades. Although granulomas are thought to protect the host by containing Mtb in a confined area and preventing bacterial dissemination to other parts of the body, it is also likely to act as a safe-harbor for the infecting bacteria to thrive and persist in a niche with a compromised immunity. This chapter summarizes various cellular events underlying TB pathogenesis and the role of different types of immune cells involved in granuloma formation.

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  1. Public Health Research Institute, New Jersey Medical School at Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ, USA

    Afsal Kolloli, Pooja Singh & Selvakumar Subbian

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    Vishwanath Venketaraman

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Kolloli, A., Singh, P., Subbian, S. (2018). Granulomatous Response to Mycobacterium tuberculosis Infection. In: Venketaraman, V. (eds) Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection. Springer, Cham. https://doi.org/10.1007/978-3-319-97367-8_3

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