Abstract
This chapter outlines the effects pregnancy has on medications used by anesthesiologists. It addresses the effects on MAC, rate of induction, volume of distribution, and levels of proteins in the pregnant female.
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Keywords
- MAC
- Rate of induction
- Volume of distribution
- Medication potency
- Levels of albumin
- Levels of 1-acid glycoprotein
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1.
MAC for volatiles is decreased up to 40% in pregnancy
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(a)
Rate of induction is faster due to greater minute ventilation and reduced functional residual capacity (FRC)
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(a)
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2.
Pregnant women have a larger volume of distribution due to expanded extracellular volume and total body water, so recovery from many anesthetic drugs is faster
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3.
The potency of some medications is increased due to decreased levels of albumin and alpha 1-acid glycoprotein for drug binding leading to more unbound drug concentration in plasma
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© 2019 Springer Nature Switzerland AG
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Wasson, C., Kelly, A., Ninan, D., Tran, Q. (2019). Effects of Pregnancy on Uptake and Distribution. In: Absolute Obstetric Anesthesia Review. Springer, Cham. https://doi.org/10.1007/978-3-319-96980-0_1
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DOI: https://doi.org/10.1007/978-3-319-96980-0_1
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-96979-4
Online ISBN: 978-3-319-96980-0
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