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Change and Maintaining Change pp 1–33Cite as

Motivating Change in Addiction via Modulation of the Dark Side

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Part of the book series: Nebraska Symposium on Motivation ((NSM,volume 65))

Abstract

The constructs of emotion and motivation are intimately linked. Throughout my career, W. Horsley Gantt and Joseph V. Brady laid a rich foundation for understanding the concept of emotion, derived from two prominent traditions of physiology and psychology: classical conditioning and operant conditioning, respectively. This framework guided my fierce interest in motivation in general and the interaction between reward and stress, which began at John Hopkins University with my thesis work under the mentorship of Zoltan Annau, with help from Solomon Synder and Joseph Brady, among many others. Using the study of the neurobiology of addiction as a framework, I argue that drug addiction can be heuristically framed as a cycle of three stages—binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation (“craving”)—that involve domains of incentive salience/pathological habits (mediated by basal ganglia circuits), reward deficits/stress surfeit (mediated by extended amygdala circuits), and executive function deficits (mediated by the frontal cortex), respectively. Movement through the three stages involves a transition from positive reinforcement that is associated with the rewarding effects of drugs of abuse to another major source of reinforcement, specifically negative reinforcement that is driven by negative emotional states (termed the “dark side” of addiction). Repeated overstimulation of the reward systems with drugs of abuse decreases reward function, characterized by a decrease in brain stimulation reward and presumbably reflecting a dysphoria-like state. The construct of negative reinforcement, defined as drug taking that alleviates a negative emotional state that is created by drug abstinence, is particularly relevant as a driving force in both the withdrawal/negative affect and preoccupation/anticipation stages of the addiction cycle. From a neurobiological perspective, the negative emotional state that drives such negative reinforcement is hypothesized to derive from excessive activation of the brain reward systems that leads to a decrease in the function of normal reward-related neurocircuitry (dopamine, opioid peptides) in the ventral striatum and persistent recruitment of anti-reward systems, reflected by sensitization of the brain stress systems (corticotropin-releasing factor, dynorphin) within the extended amygdala. This shift in motivation is hypothesized to reflect the allostatic misregulation of hedonic tone such that drug taking makes the hedonic negative emotional state worse during the process of seeking temporary relief with compulsive drug taking. Understanding the neuroplasticity of the neurocircuitry that comprises negative reinforcement that is associated with addiction is a key to understanding motivation in general and its representation in pathophysiology.

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Acknowledgements

The author thanks Michael Arends for assistance with manuscript preparation.

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  1. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA

    George F. Koob

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  1. Department of Psychology, University of Nebraska–Lincoln, Lincoln, NE, USA

    Debra A. Hope

  2. Department of Psychology, University of Nebraska–Lincoln, Lincoln, NE, USA

    Rick A. Bevins

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Koob, G.F. (2018). Motivating Change in Addiction via Modulation of the Dark Side. In: Hope, D., Bevins, R. (eds) Change and Maintaining Change. Nebraska Symposium on Motivation, vol 65. Springer, Cham. https://doi.org/10.1007/978-3-319-96920-6_1

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