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Cell Movement pp 27–60Cite as

Birkhäuser

The Role of Microenvironment in Regulation of Cell Infiltration in Glioblastoma

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Abstract

Glioblastoma multiforme (GBM) is one of the deadliest human cancers and is characterized by fast growth and aggressive invasion. GBM also communicates with microglia and macrophages which are recruited by tumor cells to facilitate growth and invasion. In this study we investigate the biochemical and cell-mechanical interactions between the glioma cells and the microenvironment including resident glial cells and M1/M2 microglia that enhance tumor invasion. We develop various types of mathematical models that involve reaction-diffusion equations or multi-scale hybrid models for the important components in this mutual interaction. In particular, we investigate the dynamics of intracellular signaling including miR-451 and AMPK, biochemical interaction of a glioma with M1/M2 microglia via CSF-1-EGF-TGF-β signaling, and glioma cell infiltration through the narrow intercellular space via the regulation of myosin II. We show that these models can replicate the key features of the experimental findings and make novel predictions to guide future experiments aimed at the development of new anti-invasive strategies.

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Acknowledgements

YJK was supported by the Basic Science Research Program through the National Research Foundation of Korea by the Ministry of Education (NRF-2015R1D1A1A0 1058702). WHL was supported by the National Institute for Mathematical Sciences (NIMS) Grant funded by the Korean government (Grant No. B18130000).

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Authors and Affiliations

  1. Department of Mathematics, Konkuk University, 120 Neungdong-ro, 05029, Gwangjin-gu, Seoul, Republic of Korea

    Yangjin Kim, Donggu Lee & Junho Lee

  2. National Institute for Mathematical Sciences, 70, Yuseong-daero 1689 beon-gil, 34047, Yuseong-gu, Daejeon, Republic of Korea

    Wanho Lee

  3. Molecular and Translational Neuroimaging Lab, Department of Radiology, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul, 110–744, Republic of Korea

    Hyejin Jeon

  4. Department of Mathematical Sciences, University of Cincinnati, 4199 French Hall West, 45221, Cincinnati, OH, USA

    Sookkyung Lim

  5. Department of Biological Sciences, Carnegie Mellon University, 5000 Forbes Avenue, 15213, Pittsburgh, PA, USA

    Soyeon Roh

  6. Department of Neurosurgery, Brigham and Women’s Hospital and Harvard Medical School, 4 Black-fan Circle, HIM 930A, Boston, MA, 02115, USA

    Sean Lawler

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  1. Yangjin Kim
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  2. Wanho Lee
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  6. Donggu Lee
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  7. Junho Lee
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  8. Sean Lawler
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Correspondence to Yangjin Kim .

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Editors and Affiliations

  1. Mathematics, University of St. Thomas, Saint Paul, MN, USA

    Magdalena Stolarska

  2. Mathematics, Purdue University Northwest, Hammond, IN, USA

    Nicoleta Tarfulea

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Kim, Y. et al. (2018). The Role of Microenvironment in Regulation of Cell Infiltration in Glioblastoma. In: Stolarska, M., Tarfulea, N. (eds) Cell Movement. Modeling and Simulation in Science, Engineering and Technology. Birkhäuser, Cham. https://doi.org/10.1007/978-3-319-96842-1_2

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