Role of the Endocytosis of Caveolae in Intracellular Signaling and Metabolism

  • Olivia Muriel
  • Miguel Sánchez-Álvarez
  • Raffaele Strippoli
  • Miguel Angel del PozoEmail author
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 57)


Caveolae are 60–80 nm invaginated plasma membrane (PM) nanodomains, with a specific lipid and protein composition, which assist and regulate multiple processes in the plasma membrane—ranging from the organization of signalling complexes to the mechanical adaptation to changes in PM tension. However, since their initial descriptions, these structures have additionally been found tightly linked to internalization processes, mechanoadaptation, to the regulation of signalling events and of endosomal trafficking. Here, we review caveolae biology from this perspective, and its implications for cell physiology and disease.



This work was supported by grants SAF2011-25047 and CSD2009-0016 from Spanish Ministry of Science and Innovation (MICINN), SAF2014-51876-R from Spanish Ministry of Economy and Competitiveness (MINECO) and co-funded by FEDER funds, 674/C/2013 from Fundació La Marató de TV3, and AICR 15-0404 from the Worldwide Cancer Research Foundation (to M.A.dP.). The CNIC is supported by the Ministry of Economy, Industry and Competitiveness (MEIC), and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).

Competing Financial Interests

The authors declare no competing financial interests exist.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Olivia Muriel
    • 1
    • 2
  • Miguel Sánchez-Álvarez
    • 1
  • Raffaele Strippoli
    • 1
    • 3
  • Miguel Angel del Pozo
    • 1
    Email author
  1. 1.Mechanoadaptation and Caveolae Biology Lab, Cell and Developmental Biology AreaCentro Nacional de Investigaciones CardiovascularesMadridSpain
  2. 2.Department of Fundamental MicrobiologyUniversity of LausanneLausanneSwitzerland
  3. 3.Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and HematologySapienza University of RomeRomeItaly

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