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Thoracic Pathology

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Oncological Surgical Pathology

Abstract

The thoracic chapter provides an overview of the most important neoplastic conditions that may affect the lung, pleura, and mediastinum. Although it is impossible to be too inclusive of every condition that may affect the thorax, we have attempted to provide a balanced overview of different neoplastic conditions avoiding redundancy. In some areas where significant changes have taken place, a more detailed discussion has been provided. Even though, in some areas, we have expressed our personal opinion, we have tried to maintain a balance in the discussion.

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References

  1. Wahbah M, Boroumand N, Castro C, et al. Changing trends in the distribution of the histologic types of lung cancer: a review of 4,439 cases. Ann Diagn Pathol. 2007;11:89–96.

    PubMed  Google Scholar 

  2. Morita T. A statistical study of lung cancer in the annual of pathological autopsy cases in Japan, from 1958 to 1997 with reference to time trends of lung cancer in the world. Jpn J Cancer Res. 2002;93:15–23.

    PubMed  PubMed Central  CAS  Google Scholar 

  3. Grippi MA. Clinical aspects of lung cancer. Semin Roentgenol. 1990;25:12–24.

    PubMed  CAS  Google Scholar 

  4. World Health Organization Classification of Tumours. In: Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC, editors. Pathology & genetics. Tumors of the lung, pleura, thymus, and heart. Lyon: IARC Press; 2004.

    Google Scholar 

  5. Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG, editors. WHO Classification of Tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press; 2015.

    Google Scholar 

  6. Travis WD, Garg K, Franklin WA, et al. Bronchioloalveolar carcinoma and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria. J Thorac Oncol. 2006;1:S13–9.

    PubMed  Google Scholar 

  7. Travis WD, Brambilla E, Noguchi M, et al. International Association for the study of lung cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of lung adenocarcinoma. JTO. 2011;6:244–85.

    PubMed  Google Scholar 

  8. Travis WD, Asamura H, Bankier AA, et al. The IASLC lung cancer staging project: proposal for coding T categories for subsolid nodules and assessment of tumor size in part-solid tumors in the forthcoming eighth edition of the TNM classification of lung cancer. J Thorac Oncol. 2016;11:1204–23.

    PubMed  Google Scholar 

  9. Liebow AA. Bronchiolo-alveolar carcinoma. Adv Int Med. 1960;10:329–58.

    CAS  Google Scholar 

  10. Overholt RH, Meissner WA, Delmonico E. Favorable bronchiolar carcinoma. Chest. 1955;27:403–13.

    CAS  Google Scholar 

  11. Watson I, Farppour A. Terminal bronchiolar or “Alveolar Cell” cancer of the lung: two hundred sixty-five cases. Cancer. 1966;19:776–80.

    PubMed  CAS  Google Scholar 

  12. Belgrad R, Good A, Woolner LB. Alveolar-cell carcinoma (Terminal Bronchiolar Carcinoma): a study of surgically excised tumors with special emphasis on localized lesions. Radiology. 1962;79:789–98.

    PubMed  CAS  Google Scholar 

  13. Munell ER, Lawson RC, Keller DF. Solitary bronchiolar (alveolar cell) carcinoma of the lung. J Thorqac Cardiovasc Surg. 1966;52:261–70.

    Google Scholar 

  14. Rosenblatt MB, Lisa JR, Collier F. Primary and metastatic bronchiolo-alveolar carcinoma. Chest. 1967;52:147–52.

    CAS  Google Scholar 

  15. Bennett DE, Sasser WF. Bronchiolar carcinoma: a valid clinicopathologic entity? A study of 30 cases. Cancer. 1969;24:876–87.

    PubMed  CAS  Google Scholar 

  16. Delarue NC, Anderson W, Sanders D, Starr J. Bronchiolo-alveolar carcinoma: a reappraisal after 24 years. Cancer. 1972;29:90–7.

    PubMed  CAS  Google Scholar 

  17. Manning JT, Spjut HJ, Tsechen JA. Bronchioloalveolar carcinoma: the significance of two histopathologic types. Cancer. 1984;54:525–34.

    PubMed  Google Scholar 

  18. Lena O, Papalia E, Ruffini E, et al. Stage I pure bronchioloalveolar carcinoma: recurrences, survival and comparison with adenocarcinoma. Eur J Cardiothorac Surg. 2003;23:409–14.

    Google Scholar 

  19. Ebright MI, Zakoski MF, Martin J, et al. Clinical pattern and pathologic stage but not histologic features predict outcome for bronchioloalveolar carcinoma. Ann Thorac Surg. 2002;74:1640–7.

    PubMed  Google Scholar 

  20. Noguchi M, Morikawa A, Kawasaki M, et al. Small adenocarcinoma of the lung: histologic characteristics and prognosis. Cancer. 1995;75:2844–52.

    PubMed  CAS  Google Scholar 

  21. Warth A, Muley T, Meister M, et al. The novel histologic international association for the study of lung cancer/American thoracic society/European respiratory society classification system of lung adenocarcinoma is a stage independent predictor of survival. J Clin Oncol. 2012;30:1438–46.

    PubMed  Google Scholar 

  22. Birin O, Kappetein AP, Takkenberg JJM, et al. Survival after pathological stage IA non-small cell lung cancer: tumor size matters. Ann Thorac Surg. 2005;79:1137–41.

    Google Scholar 

  23. Tsuta K, Kawago M, Inoue E, et al. The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. Lung Cancer. 2013;81:371–6.

    PubMed  Google Scholar 

  24. Van Schil PE, Asamura H, Rusch VW, et al. Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification. Eur Respir J. 2012;39:478–86.

    PubMed  Google Scholar 

  25. Travis WD, Brambilla E, Noguchi M, et al. Diagnosis of lung adenocarcinoma in resected specimens. Arch Pathol Lab Med. 2013;137:685–705.

    PubMed  Google Scholar 

  26. Yoshizawa A, Sumiyoshi S, Sonobe M, et al. Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: analysis of 440 Japanese patients. JTO. 2013;8:52–61.

    PubMed  CAS  Google Scholar 

  27. Borczuk AC, Qian F, Kazeros A, et al. Invasive size is an independent predictor of survival in pulmonary adenocarcinoma. Am J Surg Pathol. 2009;33:462–9.

    PubMed  PubMed Central  Google Scholar 

  28. Weissferdt A, Klahor N, Marom E, et al. Early pulmonary adenocarcinoma (T1N0M0): a clinical, radiological, surgical, and pathological correlation of 104 cases. The M D Anderson Cancer Center Experience. Mod Pathol. 2013;26:1065–75.

    PubMed  Google Scholar 

  29. Weissferdt A, Moran CA. Reclassification of early stage pulmonary adenocarcinoma and its consequences. J Thorac Dis. 2014;6(Suppl 5):S581–8.

    PubMed  PubMed Central  Google Scholar 

  30. Weissferdt A, Walsh G, Kaiser L, Moran CA. Pulmonary adenocarcinoma T1N0M0 and its classification. Semin Diagn Pathol. 2014;31:260–4.

    PubMed  Google Scholar 

  31. Weissferdt A, Kalhor N, Moran CA. Well-differentiated adenocarcinoma-bronchioloalveolar carcinoma-in situ adenocarcinoma: a conundrum. Adv Anat Pathol. 2013;20:347–51.

    PubMed  Google Scholar 

  32. Takizawa T, Terashima M, Koike T, et al. Lymph node metastasis in small peripheral adenocarcinoma of the lung. J Thorac Cardiovasc Surg. 1998;116:276–80.

    PubMed  CAS  Google Scholar 

  33. Konaka C, Ikeda N, Hiyoshi T, et al. Peripheral non-small lung cancers 2.0 cm or less in diameter: proposed criteria for limited pulmonary resection based upon clinicopathological presentation. Lung Cancer. 1998;21:185–91.

    PubMed  CAS  Google Scholar 

  34. Mori M, Rao S, Popper HH, et al. Atypical adenomatous hyperplasia of the lung: a probable forerunner in the development of adenocarcinoma of the lung. Mod Pathol. 2001;14:72–84.

    PubMed  CAS  Google Scholar 

  35. Selamat SA, Galler JS, Joshi AD, et al. DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PLoS One. 2011;6:e21443.

    PubMed  PubMed Central  CAS  Google Scholar 

  36. Maeshima AM, Tochigi N, Yoshida A, et al. Clinicopathologic analysis of multiple (five or more) atypical adenomatous hyperplasia (AAHs) of the lung: evidence for AAH-Adenocarcinoma sequence. JTC. 2010;5:466–71.

    Google Scholar 

  37. McIntire MG, Santagata S, Ligon K, et al. Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung. Am J Tranl Res. 2010;10:309–15.

    Google Scholar 

  38. Gu B, Burt BM, Merritt RE, et al. A dominant adenocarcinoma with multifocal ground glass lesions does not behave as advanced disease. Ann Thorac Surg. 2013;96:411–8.

    PubMed  Google Scholar 

  39. Kobayashi Y, Mitsudomi T, Sakao Y, et al. Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with growth and without growth. Ann Oncol. 2015;26:156–61.

    PubMed  CAS  Google Scholar 

  40. Liu M, He WX, Song N, et al. Discrepancy of epidermal growth factor receptor mutation in lung adenocarcinoma presenting as multiple ground-glass opacities. Eur J Cardiothorac Surg. 2016;50:909–13.

    PubMed  Google Scholar 

  41. Sivakumar S, San Lucas FA, McDowell TL, et al. Genomic landscape of atypical adenomatous hyperplasia reveals divergent modes to lung adenocarcinoma. Cancer Res. 2017;26. https://doi.org/10.1158/0008-5472.

  42. Weichert W, Warth A. Early lung cancer with lepidic growth pattern: adenocarcinoma in situ, minimally invasive adenocarcinoma, and lepidic predominant adenocarcinoma. Curr Opin Pul Med. 2014;20:309–16.

    CAS  Google Scholar 

  43. Klebe S, Henderson DW. Factors and fiction: premalignant lesions of lung tissues. Pathology. 2013;45:305–15.

    PubMed  CAS  Google Scholar 

  44. Fiala O, Pesek M, Skrickova J, et al. Thyroid transcription factor 1 expression is associated with outcome of patients with non-squamous non-small cell lung cancer treated with pemetrexed-based chemotherapy. Tuor Biol. 2017;39(2):1010428317691186.

    Google Scholar 

  45. Yoshimura K, Inoue Y, Mori K, et al. Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non-small cell lung cancer. Genes Chromosomes Cancer. 2017;56:570–81.

    PubMed  CAS  Google Scholar 

  46. Czapiewski P, Gorczynski A, Radecka K, et al. Expression of SOX11, PAX5, TTF-1, and ISL-1 in medulloblastoma. Pathol Res Pract. 2016;212:965–71.

    PubMed  CAS  Google Scholar 

  47. Lee S, Han JS, Chang A, et al. Small cell-like change in prostatic intraepithelial neoplasia, intraductal carcinoma, and invasive prostatic carcinoma: a study of 7 cases. Hum Pathol. 2013;44:427–31.

    PubMed  Google Scholar 

  48. Matoso A, Singh K, Jacob R, et al. Comparison of thyroid transcription factor-1 expression by 2 monoclonal antibodies in pulmonary and nonpulmonary primary tumors. Appl Immunohistochem Mol Morphol. 2010;18:142–9.

    PubMed  PubMed Central  CAS  Google Scholar 

  49. Siami K, McCluggage WG, Ordonez NG, et al. Thyroid transcription factor-1 expression in endometrial and endocervical adenocarcinomas. Am J Surg Pathol. 2007;31:1759–63.

    PubMed  Google Scholar 

  50. Rehhi B, Deodhar KK, Menon S, et al. Napsin A and WT1 are useful immunohistochemical markers for differentiating clear cell carcinoma ovary from high-grade serous carcinoma. APMIS. 2018;126:45–55.

    Google Scholar 

  51. Golstraw P, Chansky K, Crowley J, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (Eight) edition of the TNM classification for lung cancer. JTO. 2016;11:39–51.

    Google Scholar 

  52. Davison AM, Lowe JW, Da Costa P. Adenocarcinoma arising in a mucinous cystadenoma of the lung. Thorax. 1992;47:129–30.

    PubMed  PubMed Central  CAS  Google Scholar 

  53. Traub B. Mucinous cystadenoma of the lung [Letter]. Arch Pathol Lab Med. 1991;115:740.

    PubMed  CAS  Google Scholar 

  54. Kragel PJ, Devaney KO, Meth BM, et al. Mucinous cystadenoma of the lung: a report of two cases with immunohistochemical and ultrastructural analysis. Arch Pathol Lab Med. 1990;114:1053–6.

    PubMed  CAS  Google Scholar 

  55. Dixon AY, Moran JF, Wesselius L, et al. Pulmonary mucinous cystic tumor: case report with review of the literature. Am J Surg Pathol. 1993;17:722–8.

    PubMed  CAS  Google Scholar 

  56. Gao ZH, Urbanski SJ. The spectrum of pulmonary mucinous cystic neoplasia: a clinicopathologic and immunohistochemical study of ten cases and review of literature. Am J Clin Pathol. 2005;124(1):62–70.

    PubMed  Google Scholar 

  57. Graeme-Cook F, Mark EJ. Pulmonary mucinous cystic tumors of borderline malignancy. Hum Pathol. 1991;22:185–90.

    PubMed  CAS  Google Scholar 

  58. Bacha D, et al. A pulmonary mucinous cystic tumor of borderline malignancy. Pathologica. 2008;100(3):189–91.

    PubMed  CAS  Google Scholar 

  59. Higashiyama M, Doi O, Kodama K, et al. Cystic mucinous adenocarcinoma of the lung: two cases of cystic variant of mucus-producing lung adenocarcinoma. Chest. 1992;101:763–6.

    PubMed  CAS  Google Scholar 

  60. Moran CA. Review Article- Mucin-rich tumors of the lung. Adv Anat Pathol. 1995;2(5):299–305.

    Google Scholar 

  61. Moran CA, Hochholzer L, Fishback N, et al. Mucinous (so-called colloid) carcinomas of the lung. Mod Pathol. 1992;5:634–8.

    PubMed  CAS  Google Scholar 

  62. Zenali MJ, Weissferdt A, Solis LM, et al. An update on clinicopathological, Immunohistochemical, and molecular profiles of colloid carcinoma of the lung. Hum Pathol. 2015;46:836–42.

    PubMed  CAS  Google Scholar 

  63. Kish JK, Ro JY, Ayala AG, et al. Primary mucinous adenocarcinoma of the lung with signet-ring cells: a histochemical comparison with signet-ring cell carcinomas from other sites. Hum Pathol. 1989;20:1097–102.

    PubMed  CAS  Google Scholar 

  64. Sarma DP, Hoffmann EO. Primary signet-ring cell carcinoma of the lung. Hum Pathol. 1990;21:459–60.

    PubMed  CAS  Google Scholar 

  65. Hayashi H, Kitamura H, Nakatani Y, et al. Primary signet-ring cell carcinoma of the lung: histochemical and Immunohistochemical characterization. Hum Pathol. 1999;30:378–83.

    PubMed  CAS  Google Scholar 

  66. Castro CY, Moran CA, Flieder DG, Suster S. Primary signet-ring cell adenocarcinoma of the lung: a clinicopathological study of 15 cases. Histopathology. 2001;39:397–401.

    PubMed  CAS  Google Scholar 

  67. Silver SA, Askin FB. True papillary carcinoma of the lung: a distinct clinicopathologic entity. Am J Surg Pathol. 1997;21:43–51.

    PubMed  CAS  Google Scholar 

  68. Moran CA, Jagirdar J, Suster S. Papillary lung adenocarcinoma with prominent “morular” component. Am J Clin Pathol. 2004;122:106–9.

    PubMed  Google Scholar 

  69. Amin MB, Tamboli P, Merchant SH, et al. Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance. Am J Surg Pathol. 2002;26:358–64.

    PubMed  Google Scholar 

  70. Kuroda N, Hamaguchi N, Takeuchi E, et al. Lung adenocarcinoma with micropapillary pattern: a clinicopathological study of 25 cases. APMIS. 2006;114:381–5.

    PubMed  CAS  Google Scholar 

  71. Bishop J, Teruya-Feldstein J, Westra WH, et al. p40 is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol. 2012;25:405–15.

    PubMed  CAS  Google Scholar 

  72. Takahiro T, Tsuta K, Kyohei M, et al. App Immunohistochem Mol Morphol. 2014;22:377–82.

    Google Scholar 

  73. Setoodeh R, Setoodeh S, Tahmasbi M, Hakam A. Analysis of p40 (Np63) immunoreactivity in pulmonary squamous cell carcinoma and adenocarcinoma. Am J Clin Pathol. 2013;140(suppl _1):A173.

    Google Scholar 

  74. Tran L, Mattsson J, Bjorn N, et al. Various antibody clones of napsin, thyroid transcription factor 1, and p40 and comparisons with cytokeratin 5 and p63 in histopathologic diagnostics of non-small cell lung carcinoma. Appl Immunohistochem Mol Morphol. 2016;24:648–59.

    PubMed  CAS  Google Scholar 

  75. Lewis J, Thorstad W, Chernock R, et al. p16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status. Am J Surg Pathol. 2010;34:1088–96.

    PubMed  Google Scholar 

  76. Meshman J, Wang PC, Chin R, et al. Prognostic significance of p16 in squamous cell carcinoma of the larynx and hypopharynx. Am J Otolaryngol. 2017;38:31–7.

    PubMed  Google Scholar 

  77. Coates SN, Strindlund K, Loljung L, et al. Expression of p16 in squamous cell carcinoma of the mobile tongue is independent of HPV infection despite presence of the HPV-receptor syndecan-1. BCJ. 2015;113:321–6.

    Google Scholar 

  78. Cosner D, Kumar T, Qu Z, Zhang P. Nuclear p16 staining is positive in a quarter of squamous cell carcinomas of lung primary. Am J Clin Pathol. 2015;144(suppl 2):A278.

    Google Scholar 

  79. Weissferdt A. Large cell carcinoma of lung: on the verge of extinction. Semin Diagn Pathol. 2014;31:278–88.

    PubMed  Google Scholar 

  80. Churg A. The fine structure of large cell undifferentiated carcinoma of the lung. Evidence for its relation to squalus cell carcinoma and adenocarcinoma. Hum Pathol. 1978;9:143–56.

    PubMed  CAS  Google Scholar 

  81. Yesner R. Large cell carcinoma of the lung. Semin Diagn Pathol. 1985;2:255–69.

    PubMed  CAS  Google Scholar 

  82. Humphrey PA, Scroggs MW, Roggli VL, Shelburne JD. Pulmonary carcinoma with sarcomatoid element: an Immunohistochemical and ultrastructural analysis. Hum Pathol. 1988;19:155–65.

    PubMed  CAS  Google Scholar 

  83. Ro J, Chen JL, Lee JS, Sahin AA, Ordonez NG, Ayala AG. Sarcomatoid carcinoma of the lung. Immunohistochemical and ultrastructural studies of 14 cases. Cancer. 1992;69:376–86.

    PubMed  CAS  Google Scholar 

  84. Fishback NF, Travis WD, Moran CA, et al. Pleomorphic (spindle/giant cell) carcinoma of the lung. Cancer. 1994;73:2936–45.

    PubMed  CAS  Google Scholar 

  85. Weissferdt A, Kalhor N, Rodriguez-Canales J, et al. Spindle cell and pleomorphic (“sarcomatoid”) carcinomas of the lung: an Immunohistochemical analysis of 86 cases. Hum Pathol. 2017;59:1–9.

    PubMed  CAS  Google Scholar 

  86. Weissferdt A, Moran CA. Primary giant cell carcinomas of the lung: a clinicopathological and Immunohistochemical analysis of seven cases. Histopathology. 2016;68:680–5.

    PubMed  Google Scholar 

  87. Weissferdt A, Kalhor N, Correa AM, Moran CA. “Sarcomatoid” carcinomas of the lung: a clinicopathological study of 86 cases with a new perspective on tumor classification. Hum Pathol. 2017;63:14–26.

    PubMed  Google Scholar 

  88. Pyo JS, Kang G, Cho WJ, Choi SB. Clinicopathological significance and concordance analysis of c-MET immunohistochemistry in non-small cell lung cancers: a meta-analysis. Pathol Res Pract. 2016;212:710–6.

    PubMed  CAS  Google Scholar 

  89. Park S, Koh J, Kim DW, et al. MET amplification, protein expression, and mutations in pulmonary adenocarcinoma. Lung Cancer. 2015;90:381–7.

    PubMed  Google Scholar 

  90. Li N, Niu FY, Han JF, et al. Predictive and prognostic value of de novo MET expression in patients with advance non-small cell lung cancer. Lung Cancer. 2015;90:375–80.

    PubMed  Google Scholar 

  91. Watermann I, Schmitt B, Stellmacher F, et al. Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation? Diagn Pathol. 2015;10:130.

    PubMed  PubMed Central  CAS  Google Scholar 

  92. Routhier CA, Mochel MC, Lynch K, et al. Comparison of 2 monoclonal antibodies for Immunohistochemical detection of BRAFV600E mutation in malignant melanoma, pulmonary carcinoma, gastrointestinal carcinoma, thyroid carcinoma, and gliomas. Hum Pathol. 2103;44:2563–70.

    Google Scholar 

  93. Marchetti A, Felicioni L, Malatesta S, et al. Clinical features and outcome of patients with non-small cell lung cancer harboring BRAF mutations. J Clin Oncol. 2011;29:3574–9.

    PubMed  CAS  Google Scholar 

  94. Piton N, Borrini F, Bolognese A, et al. KRAS and BRAF mutation detection: is immunohistochemistry a possible alternative to molecular biology in colorectal cancer? Gastroenterol Res Pract. 2015; Article ID 753903.

    Google Scholar 

  95. Cooper WA, Tran T, Vilain RE, et al. PD-L1 expression is a favorable prognostic factor in early stage non-small cell carcinoma. Lung Cancer. 2015;89:181–8.

    PubMed  Google Scholar 

  96. Bobbio A, Alifano M. Immune therapy of non-small cell lung cancer. The future. Pharmacol Res. 2015;99:217–22.

    PubMed  CAS  Google Scholar 

  97. Koss MN. Pulmonary blastoma. Lung Cancer. 1994:349–62.

    Google Scholar 

  98. Berho M, Moran CA, Suster S. Malignant mixed epithelial/mesenchymal neoplasms of the lung. Semin Diagn Pathol. 1995;12:123–39.

    PubMed  CAS  Google Scholar 

  99. Spencer H. Pulmonary blastoma. J Pathol Bacteriol. 1961;82:161–5.

    Google Scholar 

  100. Souza RC, Peasly ED, Takaro T. Pulmonary blastoma – a distinct group of carcinosarcomas of the lung. Ann Thorac Surg. 1965;1:259–68.

    PubMed  CAS  Google Scholar 

  101. Bauermeister DE, Jennings ER, Beland AH, Judson HA. Pulmonary blastoma –a form of carcinosarcoma. Am J Clin Pathol. 1966;46:322–9.

    PubMed  CAS  Google Scholar 

  102. Nakatani Y, Kitamura H, Inayama Y, et al. Pulmonary adenocarcinoma of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low grade and high grade forms. Am J Surg Pathol. 1998;22:399–411.

    PubMed  CAS  Google Scholar 

  103. Cohen RE, Weaver MG, Montenegro HD, Abdul-Karim FW. Pulmonary blastoma with malignant melanoma component. Arch Pathol Lab Med. 1990;114:1076–8.

    PubMed  CAS  Google Scholar 

  104. Nakatani Y, Myyagi Y, Takemura T, et al. Aberrant nuclear/cytoplasmic localization and gene mutation of [beta]-catenin in classic pulmonary blastoma: [beta]-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma. Am J Surg Pathol. 2004;28:921–7.

    PubMed  Google Scholar 

  105. Addid BJ, Corrin B. Pulmonary blastoma, carcinosarcoma and spindle cell carcinoma: an Immunohistochemical study keratin intermediate filaments. J Pathol. 1985;147:291–301.

    Google Scholar 

  106. Berean K, Truong LD, Dudley AW, Cagle PT. Immunohistochemical characterization of pulmonary blastoma. Am J Clin Pahtol. 1988;89:773–7.

    CAS  Google Scholar 

  107. Garcia-Escudero A, Gonzales-Campora R, Villar-Rodriguez JL, Lag-Asturano E. Thyroid transcription factor-1 expression in pulmonary blastoma. Histopathology. 2004;44:502–14.

    Google Scholar 

  108. Chejfec G, Cosnow I, Gould NS, Husain AN, Gould VE. Pulmonary blastoma with neuroendocrine differentiation in cell morules resembling neuroepithelial bodies. Histopathology. 1990;17:353–8.

    PubMed  CAS  Google Scholar 

  109. Koss MN, Hochlzer L, O’Leary T. Pulmonary blastomas. Cancer. 1991;67:2368–81.

    PubMed  CAS  Google Scholar 

  110. Kika G. Gann. 1908;2:84.

    Google Scholar 

  111. Kakos GS, Williams TE, Assor D, Vaskko JS. Pulmonary carcinosarcoma: etiologic, therapeutic, and prognostic considerations. J Thorac Cardiovasc Surg. 1971;61:777–83.

    PubMed  CAS  Google Scholar 

  112. Saphir O, Vass A. Carcinosarcoma. Am J Cancer. 1938;33:331–61.

    Google Scholar 

  113. Diaconita G. Bronchopulmonary carcinosarcoma. Thorax. 1975;30:682–6.

    PubMed  PubMed Central  CAS  Google Scholar 

  114. Sarma DP, Deshoteles SJ. Carcinosarcoma of the lung. J Surg Oncol. 1982;19:216–8.

    PubMed  CAS  Google Scholar 

  115. Koss MN, Hochholzer L, Frommelt RA. Carcinosarcoma of the lung: a clinicopathologic study of 66 patients. Am J Surg Pathol. 1999;23:1514–26.

    PubMed  CAS  Google Scholar 

  116. Davis MP, Eagan RT, Weisland LH, Pairolero PC. Carcinosarcoma of the lung. Mayo Clinic experience and response to chemotherapy. Mayo Clin Proc. 1984;59:598–603.

    PubMed  CAS  Google Scholar 

  117. Cupples J, Wright J. An Immunohistochemical comparison of primary carcinosarcoma and sarcoma. Pathol Res Pract. 1990;186:326–9.

    PubMed  CAS  Google Scholar 

  118. Oberndorfer S. Karzinoide Tumoren des Dunndarms. Frank Z Pathol. 1907:425–32.

    Google Scholar 

  119. Bunting CH. Multiple primary carcinomata of the ileum. Johns Hopkins Hosp Bull. 1904;165(Dec):389–94.

    Google Scholar 

  120. Gould VE, Linnoila RI, Memoli VA, Warren WH. Neuroendocrine cells and neuroendocrine neoplasms of the lung. Pathol Annu. 1983:287–330.

    Google Scholar 

  121. Paladugu RR, Benfeld JR, Pak HY, Ross RK, Teplitz RL. Bronchopulmonary Kulchitsky cell carcinomas: a new classification scheme for typical and atypical carcinoids. Cancer. 1985;55:1303–11.

    PubMed  CAS  Google Scholar 

  122. Capella C, Heitz PU, Hofler H, Solcia E, Kloppel G. Revised classification of neuroendocrine tumours of the lung, pancreas, and gut. Virchows Arch. 1994;425:547–60.

    Google Scholar 

  123. Travis WD, Rush W, Flieder DB, et al. Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am J Surg Pathol. 1998;22:934–44.

    PubMed  CAS  Google Scholar 

  124. Huang Q, Muzitansky A, Mark EJ. Pulonary neuroendocrine carcinomas: a review of 234 cases and statistical analysis of 50 cases treated at one institution using a simple clinicopathologic classification. Arch Pathol Lab Med. 2002;126:545–53.

    PubMed  Google Scholar 

  125. Moran CA, Suster S, Coppola D, Wick MR. Neuroendocrine carcinomas of the lung: a critical review. Am J Surg Pathol. 2009;13:206–21.

    Google Scholar 

  126. Sturm N, Rossi G, Lantuejoul S, et al. Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell proliferations with special interest in carcinoids. Hum Pathol. 2002;33:175–82.

    PubMed  Google Scholar 

  127. Ionescu D, Treaba D, Gilks CB, et al. Nonsmall cell lung carcinoma with neuroendocrine differentiation –an entity of no clinical prognostic significance. Am J Surg Pathol. 2007;31:26–32.

    PubMed  Google Scholar 

  128. Costes V, Marty-Ane C, Picot MC, et al. Typical and atypical bronchopulmonary carcinoid tumors: a clinicopathologic and ki-67 labeling study. Hum Pathol. 1995;26:740–5.

    PubMed  CAS  Google Scholar 

  129. Jones MH, Virtanen C, Honjoh D, et al. Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small and large cell neuroendocrine carcinoma identified by gene expression profiles. Lancet. 2004;363:775–81.

    PubMed  CAS  Google Scholar 

  130. Shibahara J, Goto A, Niki T, et al. Primary pulmonary paraganglioma: report of a functioning case with Immunohistochemical and ultrastructural study. Am J Surg Pathol. 2004;28:825–9.

    PubMed  Google Scholar 

  131. Aubertine CL, Flieder DB. Primary paraganglioma of the lung. Ann Diagn Pathol. 2004;8:237–41.

    PubMed  Google Scholar 

  132. Palau MA, Merino MJ, Quezado M. Corticotropin-producing pulmonary gangliocytic paraganglioma associated with Cushing’s syndrome. Hum Pathol. 2006;37:623–241.

    PubMed  CAS  Google Scholar 

  133. Weissferdt A, Kalhor N, Liu H, et al. Thymic neuroendocrine tumors (paraganglioma and carcinoid tumor): a comparative Immunohistochemical study of 46 cases. Hum Pathol. 2014;45:2463–70.

    PubMed  Google Scholar 

  134. Moran CA. Primary salivary gland-type tumors of the lung. Sem Diag Pathol. 1995;12:106–22.

    CAS  Google Scholar 

  135. Falk N, Weissferdt A, Kalhor N, Moran CA. Primary pulmonary salivary gland-type tumors: a review and update. Adv Anat Pathol. 2016;23:13–23.

    PubMed  CAS  Google Scholar 

  136. Elnayal A, Moran CA, Fox PS, et al. Primary salivary gland-type lung cancer: imaging and clinical predictors of outcome. AJR Am J Roentfenol. 2013;201:W57–63.

    Google Scholar 

  137. Yousem SA, Hochholzer L. Mucoepidermoid tumors of the lung. Cancer. 1987;60:1346–52.

    PubMed  CAS  Google Scholar 

  138. Heitmiller RF, Mathisen DJ, Ferry JA, et al. Mucoepidermoid lung tumors. Ann Thorac Surg. 1989;47:394–9.

    PubMed  CAS  Google Scholar 

  139. Jiang L, Li P, Xiao Z, et al. Prognostic factors of primary pulmonary mucoepidermoid carcinoma: a clinical and pathological analysis of 34 cases. Int J Clin Exp Pathol. 2014;7:6792–9.

    PubMed  PubMed Central  Google Scholar 

  140. Roden AC, Garcia JJ, Wehrs RN, et al. Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma. Mod Pathol. 2014;27:1479–88.

    PubMed  CAS  Google Scholar 

  141. Lee GD, Kang DK, Kim HR, et al. Surgical outcomes of pulmonary mucoepidermoid carcinoma: a review of 23 cases. Thorac Cardiovasc Surg. 2014;62:140–6.

    PubMed  CAS  Google Scholar 

  142. Chih-Cheng H, Yung-Han S, Shih-Wei L, et al. Surgical outcomes of pulmonary mucoepidermoid carcinoma: a review of 41 cases. PLOSone. 2017;12(5):e0176918. https://doi.org/10.1371/journal.pone.0176918.

    Article  CAS  Google Scholar 

  143. Molina JR, Aubry MC, Lewis JE, et al. Primary salivary gland-type lung cancer. Spectrum of clinical presentation, histopathologic and prognostic factors. Cancer. 2007;110:2253–9.

    PubMed  Google Scholar 

  144. Koyima T, Perez RP, Yamamoto S, Neupane P. Primary lung mucoepidermoid carcinoma: analysis of prognostic factors using surveillance, epidemiology and end results program. Clin Respir J. 2016. https://doi.org/10.1111/crj.12426.

  145. Tonon G, Modi S, Wu L, et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet. 2003;33:208–13.

    PubMed  CAS  Google Scholar 

  146. Garcia JJ, Hunt JL, Weinreb I, et al. Fluorescence in situ hybridization for detection of MALM2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. Hum Pathol. 2001;42:2001–9.

    Google Scholar 

  147. Seethala R, Dacic S, Cieply K, et al. A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol. 2010;34:1106–21.

    PubMed  Google Scholar 

  148. Bell D, El-Naggar AK. Molecular heterogeneity in mucoepidermoid carcinoma: conceptual and practical implications. Head Neck Pathol. 2013;7:23–7.

    PubMed  PubMed Central  Google Scholar 

  149. Serra A, Schackert HK, Mohr B, et al. t(11;19)(q21;p12-p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma. J Pediatr Surg. 2007;42:E23–9.

    PubMed  Google Scholar 

  150. De Oliveira R, Achcar D, Nikiforova MN, et al. Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. Hum Pathol. 2009;40:854–60.

    Google Scholar 

  151. Huo Z, Wu H, Li J, et al. Primary pulmonary mucoepidermoid carcinoma: histopathological and molecular genetic studies of 26 cases. PLoS One. 2015;10:e0143169.

    PubMed  PubMed Central  Google Scholar 

  152. Salem A, Bell D, Sepesi B, et al. Clinicopathologic and genetic features of primary bronchopulmonary mucoepidermoid carcinoma: The M D Anderson experience and comprehensive review of the literature. Virchows Arch. 2017;470:619–26.

    PubMed  CAS  Google Scholar 

  153. Han SW, Kim HP, Jeon YK, et al. Mucoepidermoid carcinoma of lung: potential target of EGFR-directed treatment. Lung Cancer. 2008;61:30–4.

    PubMed  Google Scholar 

  154. Yu Y, Song Z, Gao H, et al. EGFR L861Q mutation is frequent feature of pulmonary mucoepidermoid carcinoma. J Cancer Res Clin Oncol. 2012;138:1421–5.

    PubMed  CAS  Google Scholar 

  155. Moran CA, Suster S, Koos MN. Primary adenoid cystic carcinoma of the lung. A clinicopathological and immunohistochemical study of 16 cases. Cancer. 1994;73:1390–7.

    PubMed  CAS  Google Scholar 

  156. Ishida T, Nishino T, Oka T, et al. Adenoid cystic carcinoma of the tracheobronchial tree: clinicopathology and immunohistochemistry. J Surg Oncol. 1989;41:52–9.

    PubMed  CAS  Google Scholar 

  157. Inoue H, Iwashita A, Kaneage H, et al. Peripheral pulmonary adenoid cystic carcinoma with substantial extension to the proximal bronchus. Thorax. 1991;46:147–8.

    PubMed  PubMed Central  CAS  Google Scholar 

  158. Tian Z, et al. Differences in MYB expression and gene abnormalities further confirm that salivary cribriform basal cell tumors and adenoid cystic carcinoma are two distinct tumor entities. J Oral Pathol Med. 2015.

    Google Scholar 

  159. Fechner RE, Bentnick BR, Askew JB Jr. Acinic cell tumor of the lung: a histologic and ultrastructural study. Cancer. 1972;29:501–8.

    PubMed  CAS  Google Scholar 

  160. Moran CA, Suster S, Koss MN. Acinic cell carcinoma of the lung (“Fechner tumor”): a clinicopathologic, immunohistochemical, and ultrastructural study of five cases. Am J Surg Pathol. 1992;16:1039–50.

    PubMed  CAS  Google Scholar 

  161. Latz DR, Bubis JJ. Acinic cell tumor of the bronchus. Cancer. 1976;38:830–2.

    Google Scholar 

  162. Ghapure KJ, Desphande RK, Vishweshvara RN, et al. Acinic cell tumor of the bronchus (case report). Indian J Cancer. 1985;22:152–6.

    Google Scholar 

  163. Lee HY, et al. Primary acinic cell carcinoma of the lung with metastasis to lymph node metastasis. Arch Pathol Lab Med. 2003;127(4):e216–9.

    PubMed  Google Scholar 

  164. Moran CA, Suster S, Askin FB, Koss MN. Benign and malignant salivary gland type mixed tumors of the lung. Clinicopathologic and immunohistochemical study of eight cases. Cancer. 1994;73:2481–90.

    PubMed  CAS  Google Scholar 

  165. Weissferdt A, Moran CA. Pulmonary salivary gland type tumors with features of malignant mixed tumor (carcinoma ex-pleomorphic adenoma): a clinicopathologic study of five cases. Am J Clin Pathol. 2011;136:793–8.

    PubMed  Google Scholar 

  166. Wilson RW, Moran CA. Epithelial-myoepithelial carcinoma of the lung. Immunohistochemical and ultrastructural observations and review of the literature. Hum Pathol. 1997;28:631–5.

    PubMed  CAS  Google Scholar 

  167. Nguyen CV, Suster S, Moran CA. Pulmonary epithelial-myoepithelial carcinoma: a clinicopathologic and immunohistochemical study of 5 cases. Hum Pathol. 2009;40:366–73.

    PubMed  CAS  Google Scholar 

  168. Jeffus SK, Gardner JM, Steliga MA, et al. Hyalinizing clear cell carcinoma of the lung: case report and review of the literature. Am J Clin Pathol. 2017;148:73–80.

    PubMed  Google Scholar 

  169. England DM, Hochholzer L. Truly benign “bronchial adenoma:” report of 10 cases of mucous gland adenoma with immunohistochemical and ultrastructural findings. Am J Surg Pathol. 1985;19:887–99.

    Google Scholar 

  170. Whyte RI, Donington JS. Hamartomas of the lung. Semin Thorac Cardiovasc Surg. 2003;15(3):302–4.

    Google Scholar 

  171. Zuricalday CG, Lor F, Turner CG. Primary pedunculated leiomyosarcoma of the lung. Thorax. 1982;37:153–4.

    Google Scholar 

  172. Wick MR, Scheithauer BW, Piehler JM, Pairolero PC. Primary pulmonary leiomyosarcoma: a light and electron microscopic study. Arch Pathol Lab Med. 1982;106:510–4.

    PubMed  CAS  Google Scholar 

  173. Capewell M, Webb JN, Crompton GK. Primary leiomyosarcoma of the lung presenting with a persistent pneumothorax. Thorax. 1986;41:649–50.

    PubMed  PubMed Central  CAS  Google Scholar 

  174. Shoji F, Yoshino I, Takeshita M, et al. Pulmonary leiomyosarcoma presenting as Pancoast tumor. Pathol Res Pract. 2007;203:745–8.

    PubMed  Google Scholar 

  175. Guccion JG, Rosen SH. Bronchopulmonary leiomyosarcoma and fibrosarcoma: a study of 32 cases and review of the literature. Cancer. 1972;30:836–47.

    PubMed  CAS  Google Scholar 

  176. Jimenez JF, Uthman EO, Townsend JW, et al. Primary bronchopulmonary leiomyosarcoma in childhood. Arch Pathol Lab Med. 1986;110:348–51.

    PubMed  CAS  Google Scholar 

  177. Moran CA, Suster S, Abbondanzo SL, Koss MN. Primary leiomyosarcomas of the lung: a clinicopathologic and Immunohistochemical study of 18 cases. Mod Pathol. 1997;10:121–8.

    PubMed  CAS  Google Scholar 

  178. Przgodski RM, Moran CA, Suster S, Koss MN. Primary pulmonary rhabdomyosarcomas: a clinicopathologic and Immunohistochemical study of three cases. Mod Pathol. 1995;8:658–61.

    Google Scholar 

  179. Zeren H, Moran CA, Suster S, Fishback NK, Koss MN. Primary pulmonary sarcomas with features of monophasic synovial sarcoma: a clinicopathological, Immunohistochemical, and ultrastructural study of 25 cases. Hum Pathol. 1995;26:474–80.

    PubMed  CAS  Google Scholar 

  180. Mezzelani A, Mariani L, Tamborini E, et al. SYT-SSX fusion genes and prognosis in synovial sarcoma. Br J Cancer. 2001;85:1535–9.

    PubMed  PubMed Central  CAS  Google Scholar 

  181. Boroumand N, Raja V, Jones DV, Haque AK. SYT-SSX2 variant of primary pulmonary synovial sarcoma with focal expression of CD117 (c-Kit) protein and poor clinical outcome. Arch Pathol Lab Med. 2003;127:e201–4.

    PubMed  Google Scholar 

  182. Begueret H, Galateau-Salle F, Guillou L, et al. Primary intrathoracic synovial sarcoma: a clinicopathologic study of 40 t(X;18)-positive cases from the French Sarcoma Group and the Mesopath Group. Am J Surg Pathol. 2005;29:339–46.

    PubMed  Google Scholar 

  183. Okamoto S, Hisaoka M, Daa T, et al. Primary pulmonary synovial sarcoma: a clinicopathologic, Immunohistochemical, and molecular study of 11 cases. Hum Pathol. 2004;35:850–6.

    PubMed  Google Scholar 

  184. Yousem SA, Flynn SD. Intrapulmonary localized fibrous tumor: intraparenchymal so-called localized fibrous mesothelioma. Am J Clin Pathol. 1988;89:365–9.

    PubMed  CAS  Google Scholar 

  185. Rao N, Colby TV, Falconieri G, et al. Intrapulmonary solitary fibrous tumor: clinicopathologic and Immunohistochemical study of 24 cases. Am J Surg Pathol. 2013;37:155–66.

    PubMed  Google Scholar 

  186. Kim JM, Choi YL, Kim YJ, Park HK. Comparison and evaluation of risk factors for meningeal, pleural, and extrapleural solitary fibrous tumors: a clinicopathologic study of 92 cases confirmed by STAT6 immunohistochemical staining. Pathol Res Pract. 2017;213:619–25.

    PubMed  CAS  Google Scholar 

  187. Dails D, Liebow AA. Intravascular bronchioloalveolar tumor [abstract]. Am J Pathol. 1975;78:6a, 7a.

    Google Scholar 

  188. Corrin B, Manners B, Millard M, Weaver L. Histogenesis of the so-called “intravascular bronchioloalveolar tumours”. J Pathol. 1979;128:163–7.

    PubMed  CAS  Google Scholar 

  189. Azumi N, Chirg A. Intravascular and sclerosing bronchioloalveolar tumor: a pulmonary sarcoma of probable vascular origin. Am J Surg Pathol. 1981;5:587–96.

    PubMed  CAS  Google Scholar 

  190. Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50:970–81.

    PubMed  CAS  Google Scholar 

  191. Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol. 1986;3:259–87.

    PubMed  CAS  Google Scholar 

  192. Lee SJ, et al. Epithelioid hemangioendotheliomas with TFE3 gene translocation are compossible with CAMTA1 gene rearrangements. Oncotarget. 2016;16(7):7480–8.

    Google Scholar 

  193. Doyle LA, et al. Nuclear expression of CAMTA1 distinguishes epithelioid hemangioendothelioma from histologic mimics. Am J Surg Pathol. 2015;40:94–102.

    Google Scholar 

  194. Flucke U, et al. Epithelioid hemangioendothelioma: clinicopathologic, Immunohistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol. 2014;9:131.

    PubMed  PubMed Central  Google Scholar 

  195. Miller DL, Allen MS. Rare pulmonary tumors. Mayo Clin Proc. 1993;68:492–8.

    PubMed  CAS  Google Scholar 

  196. Patel AM, Ryu JH. Angiosarcoma in the lung. Chest. 1993;103:1531–5.

    PubMed  CAS  Google Scholar 

  197. Yousen SA. Angiosarcoma presenting in the lung. Arch Pathol Lab Med. 1986;110:112–5.

    Google Scholar 

  198. Bach MC, Bagwell SP, Fanning JP. Primary pulmonary Kaposi’s sarcoma in the acquired immunodeficiency syndrome: a cause of persistent pyrexia. Am J Med. 1988;85:274.

    PubMed  CAS  Google Scholar 

  199. Garay SM, Belenko M, Fazzini E, et al. Pulmonary manifestations of Kaposi’s sarcoma. Chest. 1987;91:39–43.

    PubMed  CAS  Google Scholar 

  200. Koss MN, Hochholzer L, Nichols PW, et al. Primary non-Hodgkin’s lymphoma and pseudolymphoma of lung: a study of 161 patients. Hum Pathol. 1983;14:1024–38.

    PubMed  CAS  Google Scholar 

  201. Herbert A, Wright DH, Isaacson PG, Smith JL. Primary malignant lymphoma of the lung: histopathologic and Immunohistochemical evaluation of nine cases. Hum Pathol. 1984;15:415–22.

    PubMed  CAS  Google Scholar 

  202. L’Hoste RJ, Filipa DA, Lieberman PH, Bretsky S. Primary pulmonary lymphoma: a clinicopathologic study of 36 cases. Cancer. 1984;54:1397–406.

    PubMed  Google Scholar 

  203. Addis BJ, Hyjek E, Isaacson PG. Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology. 1988;13:1–17.

    PubMed  CAS  Google Scholar 

  204. Nicholson AG, Wotherspoon AC, Diss TC, et al. Pulmonary B-cell non-Hodgkin’s lymphoma. The value of immunohistochemistry and gene analysis in diagnosis. Histopathology. 1995;26:395–403.

    PubMed  CAS  Google Scholar 

  205. Li G, Hansmann ML, Zwingers T, Lennert K. Primary lymphomas of the lung: morphological, Immunohistochemical and clinical features. Histopathology. 1990;16:519–31.

    PubMed  CAS  Google Scholar 

  206. Begueret H, Vergier B, Parrens M, et al. Priary lung small B-cell lymphoma versus lymphoid hyperplasia: evaluation of diagnostic criteria in 26 cases. Am J Surg Pathol. 2002;26:76–81.

    PubMed  Google Scholar 

  207. Zinzani PL, Tani M, Gabriele A, et al. Extranodal marginal zone B-cell lymphoma of MALT type of the lung: single – center experience with 12 patients. Leuk Lymphoma. 2003;44:821–4.

    PubMed  CAS  Google Scholar 

  208. Bae YA, Lee KS, Han J, et al. Marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: imaging findings in 21 patients. Chest. 2008;133:433–40.

    PubMed  Google Scholar 

  209. Ferraro P, Trastek VF, Adlakha H, et al. Primary non-Hodgkin’s lymphoma of the lung. Ann Thorac Surg. 2000;69:993–7.

    PubMed  CAS  Google Scholar 

  210. Nicholson AG, Wotherspoon AC, Jones AL, et al. Pulmonary B-cell non-Hodgkin’s lymphoma associated with autoimmune disorders: a clinicopathological review of six cases. Eur Respir J. 1996;9:2022–5.

    PubMed  CAS  Google Scholar 

  211. Rush WL, Andriko JA, Taubenberger JK, et al. Primary anaplastic large cell lymphoma of the lung: a clinicopathologic study of five patients. Mod Pathol. 2002;13:1285–92.

    Google Scholar 

  212. Yang HB, Li J, Shen T. Primary anaplastic large cell lymphoma of the lung: report of two cases and literature review. Acta Haematol. 2007;118:188–91.

    PubMed  Google Scholar 

  213. Liebow AA, Carrington CR, Friedman PJ. Lymphomatoid granulomatosis. Hum Pathol. 1972;3:457–558.

    PubMed  CAS  Google Scholar 

  214. Katzenstein AL, Carrington CR, Liebow AA. Lymphomatoid granulomatosis: a clinicopathologic study of 152 cases. Cancer. 1979;43:360–73.

    PubMed  CAS  Google Scholar 

  215. Nichols PW, Koss MN, Levine AM, Lukes RJ. Lymphomatoid granulomatosis: a T-cell disorder? Am J Med. 1982;72:467–71.

    PubMed  CAS  Google Scholar 

  216. Gaulard P, Henni T, Marolleau JP, et al. Lethal midline granuloma (polymorphic reticulosis) and lymphomatoid granulomatosis. Evidence for a monoclonal T-cell lymphoproliferative disorder. Cancer. 1988;62:705–10.

    PubMed  CAS  Google Scholar 

  217. Veltri RW, Raich PC, McClung JE, et al. Lymphomatoid granulomatosis and Epstein-Barr virus. Cancer. 1982;50:1513–7.

    PubMed  CAS  Google Scholar 

  218. Myers JL. Lymphomatoid granulomatosis: past, present,… future? Mayo Clin Proc. 1990;65:274–8.

    PubMed  CAS  Google Scholar 

  219. Medeiros LJ, Peiper SC, Elwood L, et al. Angiocentric immunoproliferative lesions: a molecular analysis of eight cases. Hum Pathol. 1991;22:1150–7.

    PubMed  CAS  Google Scholar 

  220. Song JY, et al. Lymphomatoid granulomatosis – a single institute experience: pathologic findings and clinical correlations. Am J Surg Pathol. 2015;39:141–56.

    PubMed  PubMed Central  Google Scholar 

  221. Tagliavini E, et al. Lymphomatoid granulomatosis: a practical review for pathologists dealing with this rare pulmonary lymphoproliferative process. Pathologica. 2013;105:111–6.

    PubMed  CAS  Google Scholar 

  222. Radin AL. Primary pulmonary Hodgkin’s disease. Cancer. 1990;65:550–63.

    PubMed  CAS  Google Scholar 

  223. Yousem SA, Weiss LM, Colby TV. Primary pulmonary Hodgkin’s disease: a clinicopathologic study of 15 cases. Cancer. 1986;57:1217–24.

    PubMed  CAS  Google Scholar 

  224. Gomez-Roman JJ, Sanchez-Velasco P, Ocejo-Vinyals G, et al. Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). Am J Surg Pathol. 2001;25:624–9.

    PubMed  CAS  Google Scholar 

  225. Su LD, Atayde-Perez A, Sheldon S, et al. Inflammatory myofibroblastic tumor: cytogenetic evidence supporting clonal origin. Mod Pathol. 1998;11:364–8.

    PubMed  CAS  Google Scholar 

  226. Bahadori M, Liebow AA. Plasma cell granuloma. Cancer. 1973;31:191–208.

    PubMed  CAS  Google Scholar 

  227. Pettinato G, Manivel JC, Rosa ND, Dehner LP. Inflammatory myofibroblastic tumor (plasma cell granuloma): a clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol. 1990;94:538–46.

    PubMed  CAS  Google Scholar 

  228. Cerfolio RJ, Allen MS, Nascimento AG, et al. Inflammatory pseudotumors of the lung. Ann Thorac Surg. 1999;67:933–6.

    PubMed  CAS  Google Scholar 

  229. Coffin CM, Patel A, Perkins S, et al. ALK-1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol. 2001;14:569–76.

    PubMed  CAS  Google Scholar 

  230. Liebow AA, Hubbell DS. Sclerosing hemangioma (histiocytoma, xanthoma) of the lung. Cancer. 1956;9:53–75.

    PubMed  CAS  Google Scholar 

  231. Kay S, Still WJS, Borochovitz D. Sclerosing hemangioma of the lung: an endothelial or epithelial neoplasm? Hum Pathol. 1977;8:468–74.

    PubMed  CAS  Google Scholar 

  232. Katzenstein AL, Weise DL, Fulling K, Batifora H. So-called sclerosing hemangioma of the lung: evidence of mesothelial origin. Am J Surg Pathol. 1983;7:3–14.

    PubMed  CAS  Google Scholar 

  233. Katzenstein AL, Gmelich JT, Carrington CB. Sclerosing hemangioma of the lung: a clinicopathological study of 51 cases. Am J Surg Pathol. 1980;4:343–56.

    PubMed  CAS  Google Scholar 

  234. Devouassoux-Shisheboran M, Hayashi T, Linnoila RI, et al. Clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with Immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. Am J Surg Pathol. 2000;24:906–16.

    PubMed  CAS  Google Scholar 

  235. Hanaoka J, Ohuchi M, Inoue S, et al. Bilateral multiple pulmonary sclerosing hemangioma. Jpn J Thorac Cardiovasc Surg. 2005;53:157–61.

    PubMed  Google Scholar 

  236. Kalhor N, et al. So-called sclerosing hemangioma of lung: current concept. Ann Diagn Pathol. 2010;14:60–7.

    PubMed  Google Scholar 

  237. Lin XY, et al. Pulmonary sclerosing hemangioma expression of beta-catenin, Axin, C-myc differs between the two cell types. Virchows Arch. 2012;461:59–65.

    PubMed  CAS  Google Scholar 

  238. Liebow AA, Castleman B. Benign “clear cell tumors” of the lung [abstract]. Am J Pathol. 1963;43:13a–4a.

    Google Scholar 

  239. Liebow AA, Castleman B. Benign clear cell (“sugar”) tumors of the lung. Yale J Biol Med. 1971;43:213–22.

    PubMed  PubMed Central  CAS  Google Scholar 

  240. Becker NH, Soifer I. Benign clear cell tumor (“sugar tumor”) of the lung. Cancer. 1971;27:712–9.

    PubMed  CAS  Google Scholar 

  241. Andrion A, Mazzucco G, Gugliotta P, Monga G. Benign clear cell (“sugar”) tumor of the lung. a light microscopic, histochemical and ultrastructural study with a review of the literature. Cancer. 1985;56:2657–63.

    PubMed  CAS  Google Scholar 

  242. Gaffey MJ, Mills SE, Zarbo RJ, et al. Clear cell tumor of the lung. Immunohistochemical and ultrastructural evidence of melanogenesis. Am J Surg Pathol. 1991;15:644–53.

    PubMed  CAS  Google Scholar 

  243. Lantuejoul S, Isaac S, Pinel N, et al. Clear cell tumor of the lung. an immunohistochemical and ultrastructural study supporting a pericytic differentiation. Mod Pathol. 1997;10:1001–8.

    PubMed  CAS  Google Scholar 

  244. Bonetti F, Pea M, Martignoni G, Zamboni G. PEC and sugar. Am J Surg Pathol. 1992;16:307–8.

    PubMed  CAS  Google Scholar 

  245. Azzopardi JG. Histogenesis of granular cell “myoblastoma”. J Pathol Bacteriol. 1956;71:85–94.

    PubMed  CAS  Google Scholar 

  246. Fisher ER, Wechsler H. Granular cell myoblastoma: misnomer, electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma). Cancer. 1962;15:936–54.

    PubMed  CAS  Google Scholar 

  247. Deavers M, Guinee D, Koss MN, Travis WD. Granular cell tumors of the lung: clinicopathologic study of 20 cases. Am J Surg Pathol. 1995;19:627–35.

    PubMed  CAS  Google Scholar 

  248. Van der Maten J, Blaauwgeers JL, Sutedja TG, et al. Granular cell tumors of the tracheobronchial tree. J Thorac Cardiovasc Surg. 2003;126:740–3.

    PubMed  Google Scholar 

  249. Moran CA, Hochholzer L, Rush W, Koss MN. Primary pulmonary meningiomas: a clinicopathologic and immunohistochemical study of ten cases. Cancer. 1996;78:2328–33.

    PubMed  CAS  Google Scholar 

  250. Flynn SD, Yousem SA. Pulmonary meningiomas: report of two cases. Hum Pathol. 1991;22:469–74.

    PubMed  CAS  Google Scholar 

  251. Prayson RA, Farver CF. Primary pulmonary malignant meningioma. Am J Surg Pathol. 1999;23:722–6.

    PubMed  CAS  Google Scholar 

  252. Weissferdt A, Tang X, Suster S, Wistuba II, Moran CA. Pleuropulmonary meningothelial proliferations: evidence for a common histogenesis. Am J Surg Pathol. 2015;39:1673–8.

    PubMed  Google Scholar 

  253. Suster S, Moran CA. Diffuse pulmonary meningotheliomatosis. Am J Surg Pathol. 2007;31:624–31.

    PubMed  Google Scholar 

  254. Moran CA, Suster S, Fishback NF, Koss MN. Primary intrapulmonary thymoma: a clinicopathologic and immunohistochemical study of eight cases. Am J Surg Pathol. 1995;19:304–12.

    PubMed  CAS  Google Scholar 

  255. Myers PO, Kritikos N, Bongiovanni M, et al. Primary intrapulmonary thymoma: a systematic review. Eur J Surg Oncol. 2007;33:1137–41.

    PubMed  CAS  Google Scholar 

  256. Yousem SA, Hochholzer L. Alveolar adenoma. Hum Pathol. 1986;17:1066–71.

    PubMed  CAS  Google Scholar 

  257. Burke LM, Rush WI, Khorr A, et al. Alveolar adenoma: a histochemical, immunohistochemical, and ultrastructural analysis of 17 cases. Hum Pathol. 1999;30:158–67.

    PubMed  CAS  Google Scholar 

  258. Travis WD, Borok Z, Roum JH, et al. Pulmonary Langerhans cell granulomatosis (histiocytosis X): a clinicopathologic study of 48 cases. Am J Surg Pathol. 1993;17:971–86.

    PubMed  CAS  Google Scholar 

  259. Yousem SA, Colby TV, Chen YY, et al. Pulmonary Langerhans cell histiocytosis: molecular analysis of clonality. Am J Surg Pathol. 2001;25:630–6.

    PubMed  CAS  Google Scholar 

  260. Rush WL, Andriko JA, Galareau-Salle F, et al. Pulmonary pathology of Erdheim-Chester disease. Mod Pathol. 2000;13:747–54.

    PubMed  CAS  Google Scholar 

  261. Ohori P, Yu J, Landreneau RJ, et al. Rosai-Dorfman disease of the pleura: a rare extranodal presentation. Hum Pathol. 2003;34:1210–1.

    PubMed  Google Scholar 

  262. Lottsfeldt FI, Good RA. Juvenile xanthogranuloma with pulmonary lesions. A case report. Pediatrics. 1964;33:233–8.

    PubMed  CAS  Google Scholar 

  263. Wick MR, Moran CA, Mills SE, Suster S. Immunohistochemical differential diagnosis of pleural effusions with emphasis on malignant mesothelioma. Curr Opin Pulm Med. 2001;7:187–92.

    PubMed  CAS  Google Scholar 

  264. Suster S, Moran CA. Applications and limitations of immunohistochemistry in the diagnosis of malignant mesothelioma. Adv Anat Pathol. 2006;13:316–29.

    PubMed  CAS  Google Scholar 

  265. Moran CA, Wick MR, Suster S. The role of immunohistochemistry in the diagnosis of malignant mesothelioma. Semin Diagn Pathol. 2000;17:178–83.

    PubMed  CAS  Google Scholar 

  266. Arrossi AV, Lin E, Rice D, Moran CA. Histologic assessment and prognostic factors of malignant pleural mesothelioma treated with extrapleural pneumonectomy. Am J Surg Pathol. 2008;130:754–64.

    Google Scholar 

  267. Yuosem SA, Hocholzer L. Malignant mesothelioma with osseous and cartilaginous differentiation. Arch Pathol Lab Med. 1987;111:62–6.

    Google Scholar 

  268. Henderson DW, Attwood HD, Constance TJ, et al. Lymphohistiocytoid mesothelioma: a rare lymphomatoid variant of predominantly sarcomatoid mesothelioma. Ultrastruct Pathol. 1988;12:367–84.

    PubMed  CAS  Google Scholar 

  269. Ordonez NG, Mackay B. Clear cell mesothelioma. Ultrastruct Pathol. 1996;20:331–6.

    PubMed  CAS  Google Scholar 

  270. Ordonez NG. Epithelioid mesothelioma with deciduoid features: report of four cases. Am J Surg Pathol. 2000;24:816–23.

    PubMed  CAS  Google Scholar 

  271. Peterson JT, Greenberg DS, Buffler PA. Non-asbestos related malignant mesothelioma. A review. Cancer. 1984;54:951–60.

    PubMed  Google Scholar 

  272. Ordonez NG. Value of cytokeratin 5/6 immunostain in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Am J Surg Pathol. 1998;22:1215–21.

    PubMed  CAS  Google Scholar 

  273. Dei Tos AP, Doglioni C. Calretinin: a novel tool for diagnostic immunohistochemistry. Adv Anat Pathol. 1998;5:61–6.

    PubMed  CAS  Google Scholar 

  274. Oates J, Edwards C. HBME-1, MOC-31, WT1, and calretinin: an assessment of recently described markers for mesothelioma and adenocarcinoma. Histopathology. 2000;36:341–7.

    PubMed  CAS  Google Scholar 

  275. Ordonez NG. The value of thyroid transcription factor-1, E-cadherin, BG8, WT1, and CD44S immunostaining in distinguishing epithelial pleural mesothelioma from pulmonary and non-pulmonary adenocarcinoma. Am J Surg Pathol. 2000;24:598–606.

    PubMed  CAS  Google Scholar 

  276. Collins CL, Ordonez NG, Schaefer R, et al. Thrombomodulin expression in malignant pleural mesothelioma and pulmonary adenocarcinoma. Am J Pathol. 1992;141:827–33.

    PubMed  PubMed Central  CAS  Google Scholar 

  277. Ordonez NG. Application of mesothelin immunostaining in tumor diagnosis. Am J Surg Pathol. 2003;27:1418–28.

    PubMed  Google Scholar 

  278. Hwang H, et al. p16 FISH deletion in surface epithelial mesothelial proliferations is predictive of underlying invasive mesothelioma. Am J Surg Pathol. 2014;38:681–8.

    PubMed  Google Scholar 

  279. Wu D, et al. Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis. Am J Clin Pathol. 2013;139:39–46.

    PubMed  CAS  Google Scholar 

  280. Kaplan MA, Tazelaar HD, Hayashi T, et al. Adenomatoid tumors of the pleura. Am J Surg Pathol. 1996;20:1219–23.

    PubMed  CAS  Google Scholar 

  281. Flieder D, Moran CA, Travis WD, et al. Pleuropulmonary endometriosis and pulmonary ectopic deciduosis: a clinicopathologic and immunohistochemical study of 10 cases with emphasis in diagnostic pitfalls. Hum Pathol. 1998;29:1495–503.

    PubMed  CAS  Google Scholar 

  282. Harwood TR, Gracey DR, Yokoo H. Pseudomesotheliomatous carcinoma of the lung: a variant of peripheral lung cancer. Am J Clin Pathol. 1976;65:159–67.

    PubMed  CAS  Google Scholar 

  283. Koss MN, Travis WD, Moran CA, Hocholzer L. Pseudomesotheliomatous adenocarcinoma: a reappraisal. Semin Diagn Pathol. 1992;9:117–23.

    PubMed  CAS  Google Scholar 

  284. Nishimoto Y, Ohno T, Saito K. Pseudomesotheliomatous carcinoma of the lung with histochemical and Immunohistochemical study. Acta Pathol Jpn. 1983;33:415–23.

    PubMed  CAS  Google Scholar 

  285. Koss MN, Fleming M, Przygodski RM, et al. Adenocarcinoma simulating mesothelioma: a clinicopathological and Immunohistochemical study of 29 cases. Ann Diagn Pathol. 1998;2:93–103.

    PubMed  CAS  Google Scholar 

  286. Klemperer P, Rabin CB. Primary neoplasms of the pleura. Arch Pathol. 1931;11:385–412.

    Google Scholar 

  287. Witkin GB, Rosai J. Solitary fibrous tumor of the mediastinum. Report of 14 cases. Am J Surg Pathol. 1989;13:547–57.

    PubMed  CAS  Google Scholar 

  288. Goodlad JR, Fletcher CDM. Solitary fibrous tumor arising at unusual sites: analysis of a series. Histopathology. 1991;19:512–22.

    Google Scholar 

  289. Suster S, Nascimiento AG, Miettinen M, et al. Solitary fibrous tumor of soft tissue. A clinicopathologic and Immunohistochemical study of 12 cases. Am J Surg Pathol. 1995;19:1257–66.

    PubMed  CAS  Google Scholar 

  290. England DM, Hocholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol. 1989;13:640–58.

    PubMed  CAS  Google Scholar 

  291. Westra WH, Gerald WL, Rosai J. Solitary fibrous tumor: consistent CD34 immunoreactivity and occurrence in the orbit. Am J Surg Pathol. 1994;18:992–8.

    PubMed  CAS  Google Scholar 

  292. Guseva NV, et al. The NAB2-STAT6 gene fusion in solitary fibrous tumor can be reliably detected by anchored multiplex PCR for targeted next generation sequencing. Cancer. 2016;209:303–21.

    CAS  Google Scholar 

  293. Thway K, et al. The current status of solitary fibrous tumor: diagnostic features, variants, and genetics. Int J Surg Pathol. 2016;24:281–92.

    PubMed  CAS  Google Scholar 

  294. Rosai J. Histological typing of tumours of the thymus. World Health Organization. Springer; 1999.

    Google Scholar 

  295. Castleman B. Tumors of the thymus gland. Atlas of tumor pathology, Section V – fascicle 19. Washington DC: Armed Forces Institute of Pathology; 1955.

    Google Scholar 

  296. Rosai J, Levine GD. Tumors of the thymus. Second series, fascicle 13. Washington DC: Armed Forces Institute of Pathology; 1975.

    Google Scholar 

  297. Marino M, Muller-Hermelink K. Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch. 1985;407:119–1149.

    CAS  Google Scholar 

  298. Bernatz PE, Harrison EG, Clagett OT. Thymoma: a clinicopathologic study. J Thorac Cardiovasc Surg. 1961;42:424–44.

    PubMed  CAS  Google Scholar 

  299. Travis WD, Brambilla E, Muller-Hermelink K, et al. Tumours of the lung, pleura, thymus, and heart. In: Pathology & genetics. Lyon: World Health Organization/IARC Press; 2004.

    Google Scholar 

  300. Travis WD, Brambilla E, Burke AP, et al. WHO classification of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press; 2015.

    Google Scholar 

  301. Neibauer A. The foundation for thymic cancer research: scope and contributions. Hematol Oncol Clin N Am. 2008;22:563–73.

    Google Scholar 

  302. Weissdferdt A, Kalhor N, Bishop J, et al. Thymoma: a clinicopathological correlation of 1470 cases. Hum Pathol. 2017;73:7–15; [Epub ahead of publication].

    Google Scholar 

  303. Salyer WR, Eggleston JC. Thymoma: a clinical and pathological study of 65 cases. Cancer. 1976;37:229–49.

    PubMed  CAS  Google Scholar 

  304. Moran CA, Suster S. On the histologic heterogeneity of thymic epithelial neoplasms: impact of sampling in subtyping and classification of thymoma. Am J Clin Pathol. 2000;114:760–6.

    PubMed  CAS  Google Scholar 

  305. Moran CA, Weissferdt A, Kalhor N, et al. Thymoma I. A clinicopathologic correlation of 250 cases with emphasis on the World Health Organization Schema. Am J Clin Pathol. 2012;137:444–50.

    PubMed  Google Scholar 

  306. Suster S, Moran CA. Thymoma, atypical thymoma, and thymic carcinoma: a novel conceptual approach to the classification of thymic epithelial neoplasms. Am J Clin Pathol. 1999;111:826–33.

    PubMed  CAS  Google Scholar 

  307. Chalabreysse L, Roy P, Cordier JF, et al. Correlation of the WHO schema for the classification of thymic epithelial neoplasms with prognosis: a retrospective study of 90 tumors. Am J Surg Pathol. 2002;26:1605–11.

    PubMed  Google Scholar 

  308. Rieker RJ, Hoegel J, Morresi-Hauf A, et al. Histologic classification of thymic epithelial tumors: comparison of established classification schemes. Int J Cancer. 2002;98:900–6.

    PubMed  CAS  Google Scholar 

  309. Bergh NP, Gatzinsky P, Larsson S, et al. Tumors of the thymus and thymic region: I. clinicopathological studies on thymomas. Ann Thorac Surg. 1978;25:91–8.

    PubMed  CAS  Google Scholar 

  310. Regnard JF, Magdeleinat P, Dromer C, et al. Prognostic factors and long-term results after thymoma resection: a series of 307 patients. J Throrac Cardiovasc Surg. 1996;112:376–84.

    CAS  Google Scholar 

  311. Wilkins EW, Grillo HC, Scannell JG, et al. Role of staging in prognosis and management of thymoma. Ann Thorac Surg. 1991;51:888–92.

    PubMed  Google Scholar 

  312. Bedini AV, Andreani SM, Tavecchio L, et al. Proposal of a novel system for the staging of thymic epithelial tumors. Ann Thorac Surg. 2005;80:1994–2001.

    PubMed  Google Scholar 

  313. Yamakawa Y, Masaoka A, Hashimoto T, et al. A tentative tumor-node-metastasis classification of thymoma. Cancer. 1991;68:1984–7.

    PubMed  CAS  Google Scholar 

  314. Kondo K. Tumor-node metastasis staging system for thymic epithelial tumors. J Thorac Oncol. 2010;5:S352–6.

    PubMed  Google Scholar 

  315. Masaoka A, Monden Y, Nakahara K, Tanioka T. Follow-up study of thymomas with special reference to their clinical stages. Cancer. 1981;48:2485–92.

    PubMed  CAS  Google Scholar 

  316. Koga K, Matsuno Y, Noguchi M, et al. A review of 79 thymomas: modification of staging system and reappraisal of conventional division into invasive and non-invasive thymoma. Pathol Int. 1994;44:359–67.

    PubMed  CAS  Google Scholar 

  317. Moran CA, Walsh G, Suster S, Kaiser L. Thymoma II: A clinicopathologic correlation of 250 cases with a proposed staging system with emphasis on pathological assessment. Am J Clin Pathol. 2012;137:451–61.

    PubMed  Google Scholar 

  318. Quintanilla-Martinez L, Wilkins EW, Choi N, et al. Thymoma: histologic subclassification is an independent prognostic factor. Cancer. 1994;74:606–17.

    PubMed  CAS  Google Scholar 

  319. Moran CA, Kalhor N, Suster S. Invasive spindle cell thymomas (WHO type A): a clinicopathologic correlation of 41 cases. Am J Clin Pathol. 2010;134:793–8.

    PubMed  Google Scholar 

  320. Weissferdt A, Hernandea JC, Kalhor N, Moran CA. Spindle cell thymomas: an immunohistochemical study of 30 cases. Appl Immunohistochem Mol Mophol. 2011;19:329–35.

    CAS  Google Scholar 

  321. Weissferdt A, Fujimoto J, Kalhor N, et al. Expression of PD-1 and PD-L1 in thymic epithelial neoplasms. Mod Pathol. 2017;30:826–33.

    PubMed  CAS  Google Scholar 

  322. Kuhn E, Wistuba II. Molecular pathology of thymic epithelial neoplasms. Hematol Oncol Clin N Am. 2008;22:443–55.

    Google Scholar 

  323. Snover DC, Levine GD, Rosai J. Thymic carcinoma. Five distinctive histological variants. Am J Surg Pathol. 1982;6:451–70.

    PubMed  CAS  Google Scholar 

  324. Shimosato Y, Kameya T, Nagai K, Suemasu K. Squamous cell carcinoma of the thymus. Analysis of eight cases. Am J Surg Pathol. 1977;1:109–21.

    PubMed  CAS  Google Scholar 

  325. Herczeg E, Kahn LB. Primary thymic carcinoma: an unusual case originating in a lymphocytic rich thymoma. Virchows Arch [Pathol]. 1986;409:163–9.

    CAS  Google Scholar 

  326. Wick MR, Scheithauer BW, Weiland LH, Bernatz PE. Primary thymic carcinomas. Am J Surg Pathol. 1982;6:613–30.

    PubMed  CAS  Google Scholar 

  327. Truong LD, Mody DR, Cagle PT, et al. Thymic carcinoma: a clinicopathologic study of 13 cases. Am J Surg Pathol. 1990;14:151–66.

    PubMed  CAS  Google Scholar 

  328. Kuo TT, Chang JP, Lin FJ, et al. Thymic carcinomas: histological varieties and Immunohistochemical study. Am J Surg Pathol. 1990;14:24–34.

    PubMed  CAS  Google Scholar 

  329. Hartmann CA, Roth C, Minck C, Niedobitek G. Thymic carcinoma: report of five cases and review of the literature. J Cancer Res Clin Oncol. 1990;116:69–82.

    PubMed  CAS  Google Scholar 

  330. Hsu CP, Chen CY, Chen CL, et al. Thymic carcinoma ten years experience in twenty patients. J Thorac Cardiovasc Surg. 1994;107:615–20.

    PubMed  CAS  Google Scholar 

  331. Chalabreysse L, Mastroianni BE, Adeleine P, et al. Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. Histopathology. 2004;44:367–74.

    PubMed  CAS  Google Scholar 

  332. Suster S, Rosai J. Thymic carcinoma: a clinicopathologic study of 60 cases. Cancer. 1991;67:1025–32.

    PubMed  CAS  Google Scholar 

  333. Weissferdt A, Moran CA. Thymic carcinoma, Part 1. A clinicopathologic and Immunohistochemical study of 65 cases. Am J Clin Pathol. 2012;138:103–14.

    PubMed  Google Scholar 

  334. Asamura H, Nakagawa K, Matsuno Y, et al. Thymoma needs a new staging system. Interact Cardiovasc Thorac Surg. 2004;3:163–7.

    PubMed  Google Scholar 

  335. Kondo K, van Schil P, Detterbeck FC, et al. The IALSC/ITMIG thymic epithelial tumors staging project: proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors. JTO. 2014;9:S81–7.

    PubMed  Google Scholar 

  336. Bhora FY, Chen DJ, Detterbeck FC, et al. The ITMIG/IASLC thymic epithelial tumors staging project: a proposed lymph node map for thymic epithelial tumors in the forthcoming 8th edition of the TNM classification of malignant tumors. JTO. 2014;9:S88–96.

    PubMed  Google Scholar 

  337. Nicholson AG, Detterbeck FC, Marino M, et al. The IASLC/ITMIG thymic epithelial tumors staging project: proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors. JTO. 2014;9:S73–80.

    PubMed  Google Scholar 

  338. Detterbeck FC, Asdamura H, Crowley J, et al. The IASLC/ITMIG thymic malignancies staging project: development of a stage classification for thymic malignancies. JTO. 2013;8:1467–73.

    PubMed  Google Scholar 

  339. Weissferdt A, Moran CA. Thymic carcinoma, part 2: a clinicopathologic correlation of 33 cases with a proposed staging system. Am J Clin Pathol. 2012;138:115–21.

    PubMed  Google Scholar 

  340. Weissferdt A, Kalhor N, Moran CA. Cystic well differentiated squamous cell carcinoma of the thymus: a clinicopathological and Immunohistochemical study of six cases. Histopathology. 2016;68:333–8.

    PubMed  Google Scholar 

  341. Suster S, Moran CA. Spindle cell thymic carcinoma: clinicopathologic and Immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. Am J Surg Pathol. 1999;23:691–700.

    PubMed  CAS  Google Scholar 

  342. Nonaka D, Rodriguez J, Rollo JL, Rosai J. Undifferentiated large cell carcinoma of the thymus associated with Castleman disease-like reaction: a distinctive type of thymic neoplasm characterized by an indolent behavior. Am J Surg Pathol. 2005;29:490–5.

    PubMed  Google Scholar 

  343. Matsuno Y, Morozumi N, Hirohashi S, et al. Papillary carcinoma of the thymus: report of four cases of a new microscopic type of thymic carcinoma. Am J Surg Pathol. 1998;22:873–80.

    PubMed  CAS  Google Scholar 

  344. Hasserjian RP, Klimstra DS, Rosai J. Carcinoma of the thymus with clear cell features: Report of eight cases and review of the literature. Am J Surg Pathol. 1995;19:835–41.

    PubMed  CAS  Google Scholar 

  345. Tropani TH, Tamboli P, Amin MB, et al. Thymic carcinoma with rhabdoid features. Ann Diagn Pathol. 2003;7:106–11.

    Google Scholar 

  346. Franke A, Strobel P, Fackeldey V, et al. Hepatoid thymic carcinoma: report of a case. Am J Surg Pathol. 2004;28:250–6.

    PubMed  CAS  Google Scholar 

  347. Weissferdt A, Moran CA. Anaplastic thymic carcinoma: a clinicopathologic and Immunohistochemical study of 6 cases. Hum Pathol. 2012;43:874–7.

    PubMed  CAS  Google Scholar 

  348. Weissferdt A, Moran CA. Micronodular thymic carcinoma with lymphoid hyperplasia: a clinicopathological and Immunohistochemical study of five cases. Mod Pathol. 2012;25:993–9.

    PubMed  Google Scholar 

  349. De Queiroga EM, Chikota H, Bacchi CE, et al. Rhabdomyomatous carcinoma of the thymus. Am J Surg Pathol. 2004;28:1245–50.

    PubMed  Google Scholar 

  350. Choi WW, Liu YH, Lau WH, et al. Adenocarcinoma of the thymus: report of two cases including a previously undescribed mucinous type. Am J Surg Pathol. 2003;27:124–30.

    PubMed  Google Scholar 

  351. Takahashi F, Tsuta K, Matsuno Y, et al. Adenocarcinoma of the thymus: mucinous subtype. Hum Pathol. 2005;36:19–223.

    Google Scholar 

  352. Sawai T, Inoue Y, Doi S, et al. Tubular adenocarcinoma of the thymus: case report and review of the literature. Int J Surg Pathol. 2006;14:243–6.

    PubMed  Google Scholar 

  353. Kapur P, Rakheja D, Bastasch M, et al. Primary mucinous adenocarcinoma of the thymus: a case report and review of the literature. Arch Pathol Lab Med. 2006;130:201–14.

    PubMed  Google Scholar 

  354. Ra SH, Fishbein MC, Baruch-Oren T, et al. Mucinous adenocarcinoma of the thymus: report of 2 cases and review of the literature. Am J Surg Pathol. 2007;31:1330–6.

    PubMed  Google Scholar 

  355. Maeda D, Ota S, Ikeda S, et al. Mucinous adenocarcinoma of the thymus: a distinct variant of thymic carcinoma. Lung Cancer. 2009;64:22–7.

    PubMed  Google Scholar 

  356. Kinoshita F, Shoji F, Takada K, et al. Mucinous adenocarcinoma of the thymus: report of a case. Gen Thorac Cardiovasc Surg. 2017. https://doi.org/10.1007/s11748-017-0781-1. [Epub ahead of print].

  357. Kalhor N, Moran CA. Primary thymic adenocarcinomas: a clinicopathological and immunohistochemical study of 16 cases with emphasis on the morphological spectrum of differentiation. Hum Pathol. 2018. [Epub ahead of print].

    Google Scholar 

  358. Weissferdt A, Moran CA. Neuroendocrine differentiation in thymic carcinomas: a diagnostic pitfall: an immunohistochemical analysis of 27 cases. Am J Clin Pathol. 2016;145:393–400.

    PubMed  CAS  Google Scholar 

  359. Weissferdt A, Wistuba II, Moran CA. Molecular aspects of thymic carcinoma. Lung Cancer. 2012;78:127–32.

    PubMed  Google Scholar 

  360. Weissferdt A, Lin H, Woods D, et al. HER family receptor and ligand status in thymic carcinoma. Lung Cancer. 2012;77:515–21.

    PubMed  Google Scholar 

  361. Rosai J, Higa E. Mediastinal endocrine neoplasm of probable thymic origin related to carcinoid tumor. Cancer. 1972;29:1061–74.

    PubMed  CAS  Google Scholar 

  362. Klemm KM, Moran CA. Primary neuroendocrine carcinomas of the thymus. Semin Diagn Pathol. 1999;16:32–41.

    PubMed  CAS  Google Scholar 

  363. Moran CA. Primary neuroendocrine carcinomas of the mediastinum: review of current criteria for histopathologic diagnosis and classification. Semin Diagn Pathol. 2005;22:223–9.

    PubMed  Google Scholar 

  364. Moran CA, Suster S. Neuroendocrine carcinomas (carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma): current concepts. Hematol Oncol Clin North Am. 2007;21:395–407.

    PubMed  Google Scholar 

  365. Rosai J, HIga E, Davie J. Mediastinal endocrine neoplasm in patients with multiple endocrine adenomatosis: a previously unrecognized association. Cancer. 1972;29:1075–83.

    PubMed  CAS  Google Scholar 

  366. Manes JL, Taylor HB. Thymic carcnoid in familial multiple endocrine adenomatosis. Arch Pathol. 1973;95:252–5.

    PubMed  CAS  Google Scholar 

  367. Lockich JJ, Li F. Carcinoid of the thymus with hereditary hyperparathyroidism. Ann Int Med. 1978;89:364–5.

    Google Scholar 

  368. Marchevsky AM, Dikman SH. Mediastinal carcinoid with incomplete Sipple’s syndrome. Cancer. 1979;43:2497–501.

    PubMed  CAS  Google Scholar 

  369. Stewart CA, Kingston CW. Carcinoid tumour of the thymus with Cushing’s syndrome. Pathology. 1980;12:487–94.

    PubMed  CAS  Google Scholar 

  370. Neary NM, Lopez-Chavez A, Abel BS, et al. Neuroendocrine ACTH-producing tumor of the thymus – experience with 12 patients over 25 years. J Endocrinol Metab. 2012;97:2223–30.

    CAS  Google Scholar 

  371. Moran CA, Suster S. Neuroendocrine carcinomas (Carcinoid Tumor) of the thymus. A clinicopathologic analysis of 80 cases. Am J Clin Pathol. 2000;114:100–10.

    PubMed  CAS  Google Scholar 

  372. Suster S, Moran CA. Thymic carcinoid with prominent mucinous stroma: report of a distinctive morphologic variant of thymic neuroendocrine neoplasm. Am J Surg Pathol. 1995;19:1277–85.

    PubMed  CAS  Google Scholar 

  373. Moran CA, Suster S. Angiomatoid neuroendocrine carcinoma of the thymus: report of a distinctive morphological variant of neuroendocrine tumor of the thymus resembling a vascular neoplasm. Hum Pathol. 1999;30:635–9.

    PubMed  CAS  Google Scholar 

  374. Klemm KM, Moran CA, Suster S. Pigmented thymic carcinoids: a clinicopathological and immunohistochemical study of two cases. Mod Pathol. 1999;12:946–8.

    PubMed  CAS  Google Scholar 

  375. Moran CA, Suster S. Spindle cell neuroendocrine carcinomas of the thymus: (Spindle cell thymic carcinoid): a clinicopathologic and immunohistochemical study of seven cases. Mod Pathol. 1999;12:587–91.

    PubMed  CAS  Google Scholar 

  376. Moran CA, Suster S. Primary neuroendocrine carcinoma (thymic carcinoid) of the thymus with prominent oncocytic features: a clinicopathologic study of 22 cases. Mod Pathol. 2000;13:489–94.

    PubMed  CAS  Google Scholar 

  377. Moran CA, Suster S. Cystic well-differentiated neuroendocrine carcinoma (carcinoid tumor): a clinicopathologic and immunohistochemical study of two cases. Am J Clin Pathol. 2006;126:377–80.

    PubMed  Google Scholar 

  378. Moran CA, Suster S. Thymic neuroendocrine carcinomas with combined features ranging from well differentiated (Carcinoid) to small cell carcinoma. Am J Clin Pathol. 2000;113:345–50.

    PubMed  CAS  Google Scholar 

  379. Wick MR, Scheithauer BW. Oat cell carcinoma of the thymus. Cancer. 1982;49:1652–7.

    PubMed  CAS  Google Scholar 

  380. Weissferdt A, Kalhor N, Liu H, et al. Thymic neuroendocrine tumors (paraganglioma and carcinoid tumors): a comparative immunohistochemical study of 46 cases. Hum Pathol. 2014;45:2463–70.

    PubMed  Google Scholar 

  381. Weissferdt A, Tang X, Wistuba II, Moran CA. Comparative immunohistochemical analysis of pulmonary and thymic neuroendocrine carcinomas using PAX8 and TTF1. Mod Pathol. 2013;26:1554–60.

    PubMed  CAS  Google Scholar 

  382. Gordon JA. Tumor in the anterior mediastinum containing bone and teeth. Med Chir Trans. 1827;13:12–6.

    PubMed  PubMed Central  CAS  Google Scholar 

  383. Hainsworth JD, Greco FA. Extragonadal germ cell tumors and unrecognized germ cell tumors. Semin Oncol. 1992;19:119–27.

    PubMed  CAS  Google Scholar 

  384. Dulmet EM, Macchiarini P, Suc B, Verley JM. Germ cell tumors of the mediastinum. Cancer. 1993;72:1894–901.

    PubMed  CAS  Google Scholar 

  385. Dehner LP. Germ cell tumors of the mediastinum. Sem Diagn Pathol. 1990;7:266–84.

    CAS  Google Scholar 

  386. Mullen B, Richardson DJ. Primary anterior mediastinal tumors in children and adults. Ann Thorac Surg. 1986;42:338–45.

    PubMed  CAS  Google Scholar 

  387. Davis RD, Oldham NH, Sabiston DC. Primary cysts and neoplasms of the mediastinum: Recent changes in clinical presentation, methods of diagnosis. management, and results. Ann Thorac Surg. 1987;44:229–37.

    PubMed  Google Scholar 

  388. Moran CA, Suster S. Primary germ cell tumors of the mediastinum: I. Analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging. Cancer. 1997;80:681–90.

    PubMed  CAS  Google Scholar 

  389. Moran CA, Suster S, Przygodski RM, Koss MN. Primary germ cell tumors of the mediastinum. II. Mediastinal seminomas - a clinicopathologic and immunohistochemical study of 120 cases. Cancer. 1997;80:691–8.

    PubMed  CAS  Google Scholar 

  390. Moran CA, Suster S, Koss MN. Primary germ cell tumors of the mediastinum. III Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum – a clinicopathologic and immunohistochemical study of 64 cases. Cancer. 1997;80:699–707.

    PubMed  CAS  Google Scholar 

  391. Lachman MF, Kim K, Koo BC. Mediastinal teratoma associated with Klinefelter’s syndrome. Arch Pathol Lab Med. 1986;110:1067–71.

    PubMed  CAS  Google Scholar 

  392. Aravanis C, Papasteriades E, Steriotis J. Recurrent pericarditis due to cystic teratoma of the mediastinum. Angiology. 1980;31:427–30.

    PubMed  CAS  Google Scholar 

  393. Robertson JM, Fee HJ, Mulder DG. Mediastinal teratoma causing life-threatening hemoptysis. Am J Dis Child. 1981;135:148–50.

    PubMed  CAS  Google Scholar 

  394. Deenadayalu RP, Tuuri D, Dewall RA, Johnson FG. Intrapericardial teratoma and bronchogenic cyst. J Thorac Cardiovasc Surg. 1974;67:945–52.

    PubMed  CAS  Google Scholar 

  395. Honicky RE, dePapp EW. Mediastinal teratoma with endocrine function. Am J Dis Child. 1973;126:650–3.

    PubMed  CAS  Google Scholar 

  396. Sogge MR, McDonald SD, Cofold PB. The malignant potential of the dysgenetic germ cell in Klinefelter’s syndrome. Am J Med. 1979;66:515.

    PubMed  CAS  Google Scholar 

  397. Nichols CR, Heerema NA, Palmer C, Loehrer PJ, Williams SD, Einhorn LH. Klinefelter’s syndrome associated with mediastinal germ cell neoplasm. J Clin Oncol. 1987;5:1290–4.

    PubMed  CAS  Google Scholar 

  398. Floret D, Renaud H, Monnet P. Sexual precocity and thoracic polyembryoma: Klinefelter’s syndrome? J Pediatr. 1979;94:163.

    PubMed  CAS  Google Scholar 

  399. Garnick MB, Griffin JD. Idiopathic thrombocytopenia in association with extragonadal germ cell cancer. Ann Intern Med. 1983;98:926–7.

    PubMed  CAS  Google Scholar 

  400. Nichols CR, Roth BJ, Heerema N, Griep J, Tricot G. Hematologic neoplasia associated with primary mediastinal germ cell tumors. N Engl J Med. 1990;322:1425–9.

    PubMed  CAS  Google Scholar 

  401. Orazi A, Neiman RS, Ulbright TM, Heerema NA, John K, Nichols CR. Hematopoietic precursor cells within the yolk sac tumor component are the source of secondary hematopoietic malignancies in patients with mediastinal germ cell tumors. Cancer. 1993;71:3873–81.

    PubMed  CAS  Google Scholar 

  402. Rosado-de-Christenson ML, Templeton P, Moran CA. Mediastinal germ cell tumors: radiologic and pathologic correlation. Radiographics. 1992;12:1013–30.

    PubMed  CAS  Google Scholar 

  403. Biester RJ, Lippert MC, Mills SE. Late recurrence of a seminoma. J Urol. 1987;137:749–50.

    PubMed  CAS  Google Scholar 

  404. Moran CA, Suster S. Primary mediastinal choriocarcinomas: a clinicopathologic and immunohistochemical study of eight cases. Am J Surg Pathol. 1997;21:1007–12.

    PubMed  CAS  Google Scholar 

  405. Moran CA, Suster S. Mediastinal seminomas with prominent cystic changes: a clinicopathologic study of 10 cases. Am J Surg Pathol. 1995;19:1047–53.

    PubMed  CAS  Google Scholar 

  406. Suster S, Moran CA, Dominguez-Malagon H, Quevedo-Blanco P. Germ cell tumors of the mediastinum and testis: a comparative immunohistochemical study of 120 cases. Hum Pathol. 1998;29(7):737–42.

    PubMed  CAS  Google Scholar 

  407. Jung SM, Chu PH, Shiu TF, et al. Expression of OCT4 in primary germ cell tumors and thymoma in the mediastinum. Appl Immunohistochem Mol Morphol. 2006;14:273–5.

    PubMed  CAS  Google Scholar 

  408. Liu A, Cheng L, Du J, et al. Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primary mediastinal germ cell tumors. Am J Surg Pathol. 2010;34:697–706.

    PubMed  Google Scholar 

  409. Moran CA, Suster S. Yolk sac tumors of the mediastinum with prominent spindle cell features. Am J Surg Pathol. 1997;21:1173–7.

    PubMed  CAS  Google Scholar 

  410. Moran CA, Suster S. Mediastinal yolk sac tumors associated with prominent multilocular cystic changes of thymic epithelium: a clinicopathologic and immunohistochemical study of five cases. Mod Pathol. 1997;10(8):800–3.

    PubMed  CAS  Google Scholar 

  411. Moran CA, Suster S. Primary yolk sac tumors of the mediastinum prominent hepatoid features: a clinicopathologic and immunohistochemical study of 4 cases. Am J Surg Pathol. 1997;21:1210–4.

    PubMed  CAS  Google Scholar 

  412. Downes KA, Goldblum JR, Montgomery EA, Fisher C. Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. Mod Pathol. 2001;14:179–84.

    PubMed  CAS  Google Scholar 

  413. Alaggio R, Coffin CM, Weiss SW, et al. Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age. Am J Surg Pathol. 2009;33:645–58.

    PubMed  Google Scholar 

  414. Chen M, Yang J, Zhu L, et al. Primary intrathoracic liposarcoma: a clinicopathologic study and prognostic analysis of 23 cases. J Cardiothorac Surg. 2014;9:119–26.

    PubMed  PubMed Central  CAS  Google Scholar 

  415. Razzuk MA, Ursckel HC, Race GJ, et al. Liposarcoma of the mediastinum: case report and review of the literature. J Thorac Cardiovasc Surg. 1971;61:819–26.

    PubMed  CAS  Google Scholar 

  416. Schweistzer DL, Aguam AS. Primary liposarcoma of the mediastinum: report of a case and review of the literature. J Thorac Cardiovasc Surg. 1977;74:83–97.

    Google Scholar 

  417. Standerfer RJ, Armistead SH, Paneth M. Liposarcoma of the mediastinum: report of a two cases and review of the literature. Thorax. 1981;36:693–4.

    PubMed  PubMed Central  CAS  Google Scholar 

  418. Havlicek F, Rosai J. A sarcoma of the thymic stroma with features of liposarcoma. Am J Clin Pathol. 1984;82:217–24.

    PubMed  CAS  Google Scholar 

  419. Dogan R, Kara M, Yazicioglu A, Onder S. Giant atypical lipomatous tumor of the mediastinum. Tuberk Toraks Derg. 2008;56:100–3.

    Google Scholar 

  420. Klimstra DS, Moran CA, Periono G, et al. Liposarcoma of the anterior mediastinum and thymus: a clinicopathologic study of 28 cases. Am J Surg Pathol. 1995;19:782–91.

    PubMed  CAS  Google Scholar 

  421. Hahn HP, Fletcher CDM. Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases. Am J Surg Pathol. 2007;31:1868–74.

    PubMed  Google Scholar 

  422. Ortega P, Suster D, Falconieri G, et al. Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases. Mod Pathol. 2015;28:721–31.

    PubMed  CAS  Google Scholar 

  423. Weissferdt A, Moran CA. Lipomatous tumors of the anterior mediastinum with muscle differentiation: a clinciopathological and immunohistochemical study of three cases. Vichows Arch. 2014;464:489–93.

    Google Scholar 

  424. Evans HL, Khurana KK, Kemp BL, Ayala AG. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol. 1994;18:1150–7.

    PubMed  CAS  Google Scholar 

  425. Lamovec J, Sobel HJ, Zidar A, Jerman J. Epithelioid hemangioendothelioma of the anterior mediastinum with osteoclast-giant cells. Light microscopic, immunohistochemical and electron microscopy study. Am J Clin Pathol. 1990;93:813–7.

    PubMed  CAS  Google Scholar 

  426. Toursarkissian B, O’Connor WN, Dillon ML. Mediastinal epithelioid hemangioendothelioma. Ann Thorac Surg. 1990;49:680–5.

    PubMed  CAS  Google Scholar 

  427. Weidner N. Atypical tumor of the mediastinum: epithelioid hemangioendothelioma containing metaplastic bone and osteoclastlike giant cells. Ultrastruct Pathol. 1991;15:481–8.

    PubMed  CAS  Google Scholar 

  428. Kumar A, Lopez YK, Arrossi AV, et al. Mediastinal epithelioid hemangioendothelioma. Am J Respir Crit Care Med. 2016;193:e7–8.

    PubMed  Google Scholar 

  429. Li XM, Lin XY, Xu HT, et al. Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histicoytoma. Diagn Pathol. 2013;8:103.

    PubMed  PubMed Central  Google Scholar 

  430. Suster S, Moran CA, Koss MN. Epithelioid hemangioendothelioma of the anterior mediastinum: clinicopathologic, immunohistochemical, and ultrastructural analysis of 12 cases. Am J Surg Pathol. 1994;18:871–81.

    PubMed  CAS  Google Scholar 

  431. Kardamakis D, Bouboulis N, Ravazoula P, et al. Primary hemangiosarcoma of the mediastinum. Lung Cancer. 1996;16:81–6.

    PubMed  CAS  Google Scholar 

  432. Gibbs AR, Johnson NF, Giddings JC, et al. Primary angiosarcoma of the mediastinum: light and electron microscopic demonstration of factor VIII –related antigen in neoplastic cells. Hum Pathol. 1984;15:687–91.

    PubMed  CAS  Google Scholar 

  433. Chen TJ, Chiou CC, Chen CH, et al. Metastasis of mediastinal epithelioid angiosarcoma to the finger. Am J Clin Dermatol. 2008;9:181–3.

    PubMed  Google Scholar 

  434. Weissferdt A, Kalhor N, Suster S, Moran CA. Primary angiosarcomas of the anterior mediastinum: a clinicopathologic and immunohistochemical study of 9 cases. Hum Pathol. 2010;41:1711–7.

    PubMed  CAS  Google Scholar 

  435. Anderson T, Zhang L, Hameed M, et al. Thoracic epithelioid malignant vascular tumors: a clinicopathoogic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions. Am J Surg Pathol. 2015;39:132–9.

    PubMed  PubMed Central  Google Scholar 

  436. Gupta S, Jindal SK, Vashist R, et al. Leiomyosarcoma of the mediastinum. Eur J Respir Dis. 1983;64:69–71.

    PubMed  CAS  Google Scholar 

  437. Herlitzka AJ, Gale JW. Tumors and cyst of the mediastinum. Arch Surg. 1958;76:697–703.

    CAS  Google Scholar 

  438. Lincoln JCR. Leiomyosarcoma of the anterior mediastinum. Thorax. 1965;20:362–4.

    PubMed  PubMed Central  CAS  Google Scholar 

  439. Rasaretnam R, Panabokke RG. Leiomyosarcoma of the mediastinum. Br J Dis Chest. 1975;69:63–9.

    PubMed  CAS  Google Scholar 

  440. Moran CA, Suster S, Perino G, et al. Malignant smooth muscle tumors presenting as mediastinal soft tissue masses. Cancer. 1994;74:2251–60.

    PubMed  CAS  Google Scholar 

  441. Suster S, Moran CA, Koss MN. Rhabdomyosarcomas of the anterior mediastinum: report of four cases unassociated with germ cell, teratomatous, or thymic carcinomatous components. Hum Pathol. 1994;25:349–56.

    PubMed  CAS  Google Scholar 

  442. Witkin GB, Rosai J. Solitary fibrous tumor of the mediastinum: a report of 14 cases. Am J Surg Pathol. 1989;13:547–57.

    PubMed  CAS  Google Scholar 

  443. Witkin GB, Miettinen M, Rosai J. A biphasic tumor of the mediastinum with features of synovial sarcoma: report of four cases. Am J Surg Pathol. 1989;13:490–9.

    PubMed  CAS  Google Scholar 

  444. Suster S, Moran CA. Primary synovial sarcoma of the mediastinum: a clinicopathologic, Immunohistochemical, and ultrastructural study of 15 cases. Am J Surg Pathol. 2005;29:569–78.

    PubMed  Google Scholar 

  445. Suster S, Moran CA. Malignant cartilaginous tumors of the mediastinum: clinicopathological study of six cases presenting as extraskeletal soft tissue masses. Hum Pathol. 1997;28:588–94.

    PubMed  CAS  Google Scholar 

  446. Flieder D, Moran CA, Suster S. Primary alveolar soft part sarcoma of the mediastinum: a clinicopathological and Immunohistochemical study of two cases. Histopathology. 1997;31:469–73.

    PubMed  CAS  Google Scholar 

  447. Suster S, Moran CA. Chordomas of the mediastinum: clinicopatholgoic, Immunohistochemical, and ultrastructural study of six cases presenting as posterior mediastinal masses. Hum Pathol. 1995;26:1354–62.

    PubMed  CAS  Google Scholar 

  448. Sordillo PP, Helson L, Hajdu SI, et al. Malignant schwannoma – clinical characteristics, survival, and response to therapy. Cancer. 1981;47:2503–9.

    PubMed  CAS  Google Scholar 

  449. Sorensen SA, Mulvihill JJ, Nielsen A. Long-term follow-up of von Recklinghausen neurofibromatosis: survival and malignant neoplasms. NEJM. 1986;314:1010–5.

    PubMed  CAS  Google Scholar 

  450. Boland JM, Colby TV, Folpe AL. Intrathoracic peripheral nerve sheath tumors – a clinicopathological study of 75 cases. Hum Pathol. 2015;46:419–25.

    PubMed  Google Scholar 

  451. Askin FB, Rosai J, Sibley RK, et al. Malignant small cell tumor of the thoracopulmonary region in childhood: a distinctive clinicopathologic entity of uncertain histogenesis. Cancer. 1979;43:2438–51.

    PubMed  CAS  Google Scholar 

  452. Weissferdt A, Moran CA. Primary primitive neuroectodermal tumor (PNET): a clinicopathological and Immunohistochemical study of six cases. Lung. 2012;190:677–83.

    PubMed  Google Scholar 

  453. Reali A, Mortellaro G, Allis S, et al. A case of primary mediastinal Ewing’s sarcoma/primitive neuroectodermal tumor presenting with initial compression of superior vena cava. Ann Thorac Med. 2013;8:121–3.

    PubMed  PubMed Central  Google Scholar 

  454. Bae SH, Hwang JH, Nam BD, et al. Multiple Ewing sarcoma/Primitive neuroectodermal tumors in the mediastinum. Medicine. 2016;95:e2725.

    PubMed  PubMed Central  Google Scholar 

  455. Schweigert M, Meyer C, Wolf F, Stein HJ. Peripheral primitive neuroectodermal tumor of the thymus. Interact Cardiovasc Thorac Surg. 2011;12:303–5.

    PubMed  Google Scholar 

  456. Manduch M, Dexter DF, Ellis PM, et al. Extraskeletal Ewing’s sarcoma/primitive neuroectodermal tumor of the posterior mediastinum with t(11;22)(q24;q12). Tumori. 2008;94:888–91.

    PubMed  Google Scholar 

  457. Nobles E, Lee R, Kircher T. Mediastinal Ependymoma. Hum Pathol. 1991;22:94–6.

    PubMed  CAS  Google Scholar 

  458. Doglioni C, Bontempini L, Iuzzolino P, et al. Ependymoma of the mediastinum. Arch Pathol Lab Med. 1988;112:194–6.

    PubMed  CAS  Google Scholar 

  459. Wilson RW, Moran CA. Primary ependymoma of the mediastinum: a clinicopathologic correlation of three cases. Ann Diagn Pathol. 1998;2:293–300.

    PubMed  CAS  Google Scholar 

  460. Buthker W, Feltkamp-Vroom T, Groen AS, Wieberdink J. Sympathicoblastoma in the anterior mediastinum. Dis Chest. 1964;46:531–6.

    Google Scholar 

  461. Talerman A, Gratma S. Primary ganglioneuroblastoma of the anterior mediastinum in a 61-year-old woman. Histopathology. 1983;7:967–75.

    PubMed  CAS  Google Scholar 

  462. Nagashima Y, Miyagi Y, Tanaka Y, et al. Adult ganglioneuroblastoma of the anterior mediastinum. Pathol Res Pract. 1997;193:727–32.

    PubMed  CAS  Google Scholar 

  463. Asada Y, Marutsuka K, Mitsukawa T, et al. Ganglioneuroblastoma of the thymus: an adult case with the syndrome of inappropriate secretion of antidiuretic hormone. Hum Pathol. 1996;27:506–9.

    PubMed  CAS  Google Scholar 

  464. Adam A, Hoccholzer L. Ganglioneuroblastoma of the posterior mediastinum: a clinicopathologic review of 80 cases. Cancer. 1981;47:373–81.

    PubMed  CAS  Google Scholar 

  465. Gutierres JC, Fischer AC, Sola JE, et al. Markedly improving survival of neuroblastoma: a 30-year analysis of 1646 patients. Pediatr Surg Int. 2007;23:637–46.

    Google Scholar 

  466. Kubota M, Suita S, Tajiri T, et al. Analysis of the prognostic factors relating to better clinical outcome in ganglioneuroblastoma. J Pediatr Surg. 2000;35:92–5.

    PubMed  CAS  Google Scholar 

  467. Brodeur GM, Pritchard J, Berthold F, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol. 1993;11:1466–77.

    PubMed  CAS  Google Scholar 

  468. Peuchmaur M, d’Amore ESG, Joshi VV, et al. Revision of the international neuroblastoma pathology classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma nodular. Cancer. 2003;98:2274–81.

    PubMed  Google Scholar 

  469. Addis BJ, Isaacson PG. Large cell lymphoma of the mediastinum: a B-cell tumour of probable thymic origin. Histopathology. 1986;10:379–90.

    PubMed  CAS  Google Scholar 

  470. Hoffman WJ, Momburg F, Moller P, Otto HF. Intra and extrathymic B cells in physiologic and pathologic conditions: immunohistochemical study on normal thymus and lymphofollicular hyperplasia of the thymus. Virchows Arch A Pathol Anat Histopathol. 1988;412:431–42.

    Google Scholar 

  471. Brugger W, Engelhardt R, Mertelsmann R, Kanz L. The management of primary mediastinal B-cell lymphoma with sclerosis. Ann Oncol. 1994;5:943–7.

    PubMed  CAS  Google Scholar 

  472. Jacobson JO, Aisenberg AC, Lamarre L, et al. Mediastinal large cell lymphoma: an uncommon subset of adult lymphoma curable with combined modality therapy. Cancer. 1988;62:1983–898.

    Google Scholar 

  473. Levitt LJ, Aisenberg AC, Harris NL, et al. Primary non-Hodgkin’s lymphoma of the mediastinum. CNCDER. 1982;50:2486–92.

    CAS  Google Scholar 

  474. Steidl C, Gayscone RD. The molecular pathogenesis of primary mediastinal lymphoma large B cell lymphoma. Blood. 2011;118:2659–69.

    PubMed  CAS  Google Scholar 

  475. Rosenwald A, Wright G, Leroy K, et al. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med. 2003;198:851–62.

    PubMed  PubMed Central  CAS  Google Scholar 

  476. Gunawardana J, Chan FC, Terlenius A, et al. Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma. Nat Genet. 2014;46:329–35.

    PubMed  CAS  Google Scholar 

  477. Eberle FC, Salaverria I, Steidl C, et al. Gray zone lymphoma: chromosomal aberrations with immunophenotypic and clinical correlations. Mod Pathol. 2011;24:1586–97.

    PubMed  PubMed Central  CAS  Google Scholar 

  478. Dunleavy K. Management of primary mediastinal B-cell lymphoma and gray zone lymphoma. Oncology. 2017:499–501.

    Google Scholar 

  479. Nathwani BN, Kim H, Rappaport H. Malignant lymphoma, lymphoblastic. Cancer. 1976;38:964–83.

    PubMed  CAS  Google Scholar 

  480. Strickler JG, Kurtin PJ. Mediastinal lymphoma. Semin Diagn Pathol. 1991;8:2–13.

    PubMed  CAS  Google Scholar 

  481. Sakamoto T, Yamashita K, Mizumoto C, et al. MALT lymphoma of the thymus with Sjogren’s syndrome: biphasic changes with serological abnormalities over a 4-year period following thymectomy. Int J Hematol. 2009;89:709–13.

    PubMed  CAS  Google Scholar 

  482. Kinoshita N, Ashizawa K, Abe K, et al. Mucosa-associated lymphoid tissue lymphoma of the thymus associated with Sjogren’s syndrome: report of a case. Surg Today. 2008;38:436–9.

    PubMed  Google Scholar 

  483. Lorsbach RB, Pinkus GS, Shahsafaei A, Dorfman DM. Primary marginal zone lymphoma of the thymus. Am J Clin Pathol. 2000;113:784–91.

    PubMed  CAS  Google Scholar 

  484. Weissferdt A, Moran CA. Primary MALT-type lymphoma of the thymus: a clinicopathological and immunohistochemical study of six cases. Lung. 2011;189:461–6.

    PubMed  CAS  Google Scholar 

  485. Leopold KA, Canellos GP, Rosenthal D, et al. Stage IA-IIB Hodgkin’s disease. Staging and treatment of patients with large mediastinal adenopathy. J Clin Oncol. 1989;7:1059–65.

    PubMed  CAS  Google Scholar 

  486. Pina-Oviedo S, Moran CA. Primary mediastinal classical Hodgkin lymphoma. Adv Anat Pathol. 2016;23:285–309.

    PubMed  CAS  Google Scholar 

  487. Gonin J, Kadiri H, Bensaci S, et al. Primary mediastinal anaplastic alk-1-positive large cell lymphoma of T/NK-cell type expressing CD20. Virchows Arch. 2007;450:355–8.

    PubMed  CAS  Google Scholar 

  488. Moran CA, Suster S, Fishback N, Koss MN. Mediastinal Paragangliomas: a clinicopathologic and immunohistochemical study of 16 cases. Cancer. 1993;72:2358–64.

    PubMed  CAS  Google Scholar 

  489. Moran CA, Suster S. Primary parathyroid tumors of the mediastinum: a clinicopathologic and immunohistochemical study of 17 cases. Am J Clin Pathol. 2005;124:749–54.

    PubMed  Google Scholar 

  490. Suster S, Rosai J. Multilocular thymic cyst: an acquired reactive process. Study of 18 cases. Am J Surg Pathol. 1991;15:388–98.

    PubMed  CAS  Google Scholar 

  491. Suster S, Barbuto D, Carlson G, Rosai J. Multilocular thymic cysts with pseudoepitheliomatous hyperplasia. Hum Pathol. 1991;22:455–60.

    PubMed  CAS  Google Scholar 

  492. Rosado-de-Christenson M, Pugatch RD, Moran CA, Galobardes J. Thymolipoma: analysis of 27 cases. Radiology. 1994;193:121–6.

    PubMed  CAS  Google Scholar 

  493. Moran CA, Rosado-de-Christenson M, Suster S. Thymolipoma: clinicopathologic review of 33 cases. Mod Pathol. 1995;8:741–4.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Division of Pathology and Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Neda Kalhor & Cesar A. Moran

  2. Department of Pathology, Division of Pathology/Lab Medicine, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Annikka Weissferdt

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  1. Neda Kalhor
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  1. Department of Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

    Cesar A. Moran

  2. Department of Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

    Neda Kalhor

  3. Department of Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

    Annikka Weissferdt

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Kalhor, N., Weissferdt, A., Moran, C.A. (2020). Thoracic Pathology. In: Moran, C.A., Kalhor, N., Weissferdt, A. (eds) Oncological Surgical Pathology . Springer, Cham. https://doi.org/10.1007/978-3-319-96681-6_11

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