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System Network Biology Approaches in Exploring of Mechanism Behind Mutagenesis

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Networking of Mutagens in Environmental Toxicology

Part of the book series: Environmental Science and Engineering ((ENVSCIENCE))

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Abstract

Mutagenesis is the alteration of the genetic material by the help of mutagens. Mutations that are capable of inducing any diseases have a large impact on the biological systems. Whenever mutation occurs, it not only affects any particular gene or protein, but also affects the whole system related to that gene. Changes in one system will further bring out changes in the adjacent systems, which works in coordination with the mutated system. Thus, a single mutation can have an impact on more than one system. System network biology helps in providing a new perspective of inspection of these biological systems in the form of networks with the help of mathematical representations. In this chapter, we deal with different properties of the networks that help in analyzing the network-graph and finding the most probable network that best describes the process. Here we tried to investigate the candidate protein molecule that may act as a target protein with the help of network analysis. For this, we used various datasets and software that would be used in the reconstruction of different biological networks and pathways.

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Author information

Authors and Affiliations

  1. Himalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, India

    Anukriti

  2. School of Biotechnology, Gautum Buddha University, Greater Noida, India

    Swati Uniyal

  3. Himalayan School of Biosciences & Cancer Research Institute, Swami Rama Himalayan University, Dehradun, India

    Anupam Dhasmana

  4. Department of Radiotherapy, Cancer Research Institute, Swami Rama Himalayan University, Dehradun, India

    Meenu Gupta

  5. Department of Chemical Engineering, Aalto University, Aalto, Espoo, Finland

    Kavindra Kumar Kesari

  6. Department of Health Informatics, College of Public Health and Health Informatics, Qassim University, King Abdul Aziz Road, Al Bukayriyah, Saudi Arabia

    Qazi Mohd. Sajid Jamal

  7. Department of Emergency Medical Services, Collage of Applied Medical Sciences, University of Jazan, Jazan, Kingdom of Saudi Arabia

    Mohtashim Lohani

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  1. Anukriti
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  2. Swati Uniyal
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  3. Anupam Dhasmana
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  6. Qazi Mohd. Sajid Jamal
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Corresponding author

Correspondence to Anupam Dhasmana .

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Editors and Affiliations

  1. Department of Applied Physics, Department of Bioproducts and Biosystems, Aalto University, Espoo, Finland

    Kavindra Kumar Kesari

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Anukriti et al. (2019). System Network Biology Approaches in Exploring of Mechanism Behind Mutagenesis. In: Kesari, K. (eds) Networking of Mutagens in Environmental Toxicology. Environmental Science and Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-96511-6_6

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