Abstract
Achalasia is a rare esophageal disorder for which a definitive treatment strategy has not been defined. Medical therapy plays a minor role in the treatment of achalasia and should not be considered first-line therapy. Patients fit enough to undergo endoscopic procedures or surgery for achalasia are better served with these interventions.
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References
Ates F, Vaezi MF. The pathogenesis and management of achalasia: current status and future directions. Gut Liver. 2015;9(4):449–63.
Krill JT, Naik RD, Vaezi MF. Clinical management of achalasia: current state of the art. Clin Exp Gastroenterol. 2016;9:71–82.
Goldblum JR, Whyte RI, Orringer MB, Appelman HD. Achalasia. A morphologic study of 42 resected specimens. Am J Surg Pathol. 1994;18(4):327–37.
Clark SB, Rice TW, Tubbs RR, Richter JE, Goldblum JR. The nature of the myenteric infiltrate in achalasia: an immunohistochemical analysis. Am J Surg Pathol. 2000;24(8):1153–8.
Mearin F, Mourelle M, Guarner F, Salas A, Riveros-Moreno V, Moncada S, et al. Patients with achalasia lack nitric oxide synthase in the gastro-oesophageal junction. Eur J Clin Investig. 1993;23(11):724–8.
O’Shaughnessy KM. Arterial hypertension, angina pectoris, myocardial infarction and heart failure. In: Clinical pharmacology [Internet]. 11th ed. Elsevier; 2012 [cited 20 Oct 2016 ]. Available from: https://www-clinicalkey-com.ezp-prod1.hul.harvard.edu/#!/content/book/3-s2.0-B978070204084900063X.
Vaezi MF, Richter JE. Current therapies for achalasia: comparison and efficacy. J Clin Gastroenterol. 1998;27(1):21–35.
Bassotti G, Annese V. Review article: pharmacological options in achalasia. Aliment Pharmacol Ther. 1999;13(11):1391–6.
Wong RK, Maydonovitch C, Garcia JE, Johnson LF, Castell DO. The effect of terbutaline sulfate, nitroglycerin, and aminophylline on lower esophageal sphincter pressure and radionuclide esophageal emptying in patients with achalasia. J Clin Gastroenterol. 1987;9(4):386–9.
Bortolotti M, Mari C, Lopilato C, Porrazzo G, Miglioli M. Effects of sildenafil on esophageal motility of patients with idiopathic achalasia. Gastroenterology. 2000;118(2):253–7.
O’Shaughnessy KM. Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs. In: Clinical pharmacology [Internet]. 11th ed. Elsevier; 2012 [cited 20 Oct 2016]. Available from: https://www-clinicalkey-com.ezp-prod1.hul.harvard.edu/#!/content/book/3-s2.0-B9780702040849000616.
O’Shaughnessy KM. Adrenergic mechanisms and drugs. In: Clinical pharmacology [Internet]. 11th ed. Elsevier; 2012 [cited 20 Oct 2016]. Available from: https://www-clinicalkey-com.ezp-prod1.hul.harvard.edu/#!/content/book/3-s2.0-B9780702040849000628?scrollTo=%23hl0000196.
Lake JM, Wong RKH. Review article: the management of achalasia – a comparison of different treatment modalities. Aliment Pharmacol Ther. 2006;24(6):909–18.
Dughera L, Chiaverina M, Cacciotella L, Cisarò F. Management of achalasia. Clin Exp Gastroenterol. 2011;4:33–41.
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Pernar, L.I.M. (2019). Medical Management of Achalasia. In: Grams, J., Perry, K., Tavakkoli, A. (eds) The SAGES Manual of Foregut Surgery . Springer, Cham. https://doi.org/10.1007/978-3-319-96122-4_34
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