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Drug Therapy of Cerebral Venous Thrombosis

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Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Abstract

Cerebral venous thrombosis (CVT) is less common than most other types of stroke but may be a more serious disorder. The treatment strategy consists of reversing the possible cause, antithrombotic therapy, and control of seizures, intracranial hypertension and headache. The anticoagulation is the mainstay treatment for CVT, including low molecular weight heparin (LMWH), heparin and warfarin. Some studies demonstrated new oral anticoagulants may be potential while need further investigation.

Keywords

  • Cerebral veins
  • Stroke
  • Treatment

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References

  1. Saposnik G, Barinagarrementeria F, Brown RD Jr, Bushnell CD, Cucchiara B, Cushman M, deVeber G, Ferro JM, Tsai FY. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:1158–92.

    CrossRef  Google Scholar 

  2. Einhaupl KM, Villringer A, Meister W, Mehraein S, Garner C, Pellkofer M, Haberl RL, Pfister HW, Schmiedek P. Heparin treatment in sinus venous thrombosis. Lancet. 1991;338:597–600.

    CAS  CrossRef  Google Scholar 

  3. de Bruijn SF, Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis. Stroke. 1999;30:484–8.

    CrossRef  Google Scholar 

  4. Coutinho J, de Bruijn SF, Deveber G, Stam J. Anticoagulation for cerebral venous sinus thrombosis. Cochrane Database Syst Rev. 2011;43:CD002005.

    Google Scholar 

  5. Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med. 2005;352:1791–8.

    CAS  CrossRef  Google Scholar 

  6. Sacco RL, Adams R, Albers G, Alberts MJ, Benavente O, Furie K, Goldstein LB, Gorelick P, Halperin J, Harbaugh R, Johnston SC, Katzan I, Kelly-Hayes M, Kenton EJ, Marks M, Schwamm LH, Tomsick T. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Circulation. 2006;113:e409–49.

    CrossRef  Google Scholar 

  7. Martinelli I, Franchini M, Mannucci PM. How I treat rare venous thromboses. Blood. 2008;112:4818–23.

    CAS  CrossRef  Google Scholar 

  8. Misra UK, Kalita J, Chandra S, Kumar B, Bansal V. Low molecular weight heparin versus unfractionated heparin in cerebral venous sinus thrombosis: a randomized controlled trial. Eur J Neurol. 2012;19:1030–6.

    CAS  CrossRef  Google Scholar 

  9. Afshari D, Moradian N, Nasiri F, Razazian N, Bostani A, Sariaslani P. The efficacy and safety of low-molecular-weight heparin and unfractionated heparin in the treatment of cerebral venous sinus thrombosis. Neurosciences. 2015;20:357–61.

    CrossRef  Google Scholar 

  10. Coutinho JM, Ferro JM, Canhao P, Barinagarrementeria F, Bousser MG, Stam J. Unfractionated or low-molecular weight heparin for the treatment of cerebral venous thrombosis. Stroke. 2010;41:2575–80.

    CAS  CrossRef  Google Scholar 

  11. Soleau SW, Schmidt R, Stevens S, Osborn A, MacDonald JD. Extensive experience with dural sinus thrombosis. Neurosurgery. 2003;52:534–44; discussion 542-534.

    CrossRef  Google Scholar 

  12. Linkins LA, Dans AL, Moores LK, Bona R, Davidson BL, Schulman S, Crowther M. Treatment and prevention of heparin-induced thrombocytopenia: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e495S–530S.

    CAS  CrossRef  Google Scholar 

  13. Dentali F, Gianni M, Crowther MA, Ageno W. Natural history of cerebral vein thrombosis: a systematic review. Blood. 2006;108:1129–34.

    CAS  CrossRef  Google Scholar 

  14. Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest. 2008;133:844s–86s.

    CAS  CrossRef  Google Scholar 

  15. Hon SF, Li HL, Cheng PW. Use of direct thrombin inhibitor for treatment of cerebral venous thrombosis. J Stroke Cerebrovasc Dis. 2012;21:915.e11–5.

    CrossRef  Google Scholar 

  16. Bacchus F, Schulman S. Clinical experience with the new oral anticoagulants for treatment of venous thromboembolism. Arterioscler Thromb Vasc Biol. 2015;35:513–9.

    CAS  CrossRef  Google Scholar 

  17. Gross PL, Weitz JI. New anticoagulants for treatment of venous thromboembolism. Arterioscler Thromb Vasc Biol. 2008;28:380–6.

    CAS  CrossRef  Google Scholar 

  18. Geisbusch C, Richter D, Herweh C, Ringleb PA, Nagel S. Novel factor xa inhibitor for the treatment of cerebral venous and sinus thrombosis: first experience in 7 patients. Stroke. 2014;45:2469–71.

    CrossRef  Google Scholar 

  19. Harder S. Pharmacokinetic and pharmacodynamic evaluation of rivaroxaban: considerations for the treatment of venous thromboembolism. Thromb J. 2014;12:22.

    CrossRef  Google Scholar 

  20. Blann AD. Non-vitamin k antagonist oral anticoagulants (noacs): a view from the laboratory. Br J Biomed Sci. 2014;71:158–67.

    CAS  CrossRef  Google Scholar 

  21. Falck-Ytter Y, Francis CW, Johanson NA, Curley C, Dahl OE, Schulman S, Ortel TL, Pauker SG, Colwell CW Jr. Prevention of VTE in orthopedic surgery patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e278S–325S.

    CAS  CrossRef  Google Scholar 

  22. Viegas LD, Stolz E, Canhao P, Ferro JM. Systemic thrombolysis for cerebral venous and dural sinus thrombosis: a systematic review. Cerebrovasc Dis. 2014;37:43–50.

    CAS  CrossRef  Google Scholar 

  23. Khan M, Kamal AK, Wasay M. Controversies of treatment modalities for cerebral venous thrombosis. Stroke Res Treat. 2010;2010:956302.

    PubMed  PubMed Central  Google Scholar 

  24. Canhao P, Cortesao A, Cabral M, Ferro JM, Stam J, Bousser MG, Barinagarrementeria F. Are steroids useful to treat cerebral venous thrombosis? Stroke. 2008;39:105–10.

    CAS  CrossRef  Google Scholar 

  25. Ameri A, Bousser MG. Cerebral venous thrombosis. Neurol Clin. 1992;10:87–111.

    CAS  CrossRef  Google Scholar 

  26. Ferro JM, Canhao P. Acute treatment of cerebral venous and dural sinus thrombosis. Curr Treat Options Neurol. 2008;10:126–37.

    CrossRef  Google Scholar 

  27. Hanley DF, Feldman E, Borel CO, Rosenbaum AE, Goldberg AL. Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension. Stroke. 1988;19:903–9.

    CAS  CrossRef  Google Scholar 

  28. Rajan Vivakaran TT, Srinivas D, Kulkarni GB, Somanna S. The role of decompressive craniectomy in cerebral venous sinus thrombosis. J Neurosurg. 2012;117:738–44.

    CrossRef  Google Scholar 

  29. Davoudi V, Keyhanian K, Saadatnia M. Risk factors for remote seizure development in patients with cerebral vein and dural sinus thrombosis. Seizure. 2014;23:135–9.

    CrossRef  Google Scholar 

  30. Ferro JM, Correia M, Rosas MJ, Pinto AN, Neves G. Seizures in cerebral vein and dural sinus thrombosis. Cerebrovasc Dis. 2003;15:78–83.

    CAS  CrossRef  Google Scholar 

  31. Kalita J, Chandra S, Misra UK. Significance of seizure in cerebral venous sinus thrombosis. Seizure. 2012;21:639–42.

    CrossRef  Google Scholar 

  32. Ferro JM, Canhao P, Bousser MG, Stam J, Barinagarrementeria F. Early seizures in cerebral vein and dural sinus thrombosis: risk factors and role of antiepileptics. Stroke. 2008;39:1152–8.

    CrossRef  Google Scholar 

  33. Canevini MP, De Sarro G, Galimberti CA, Gatti G, Licchetta L, Malerba A, Muscas G, La Neve A, Striano P, Perucca E. Relationship between adverse effects of antiepileptic drugs, number of coprescribed drugs, and drug load in a large cohort of consecutive patients with drug-refractory epilepsy. Epilepsia. 2010;51:797–804.

    CAS  CrossRef  Google Scholar 

  34. Messe SR, Sansing LH, Cucchiara BL, Herman ST, Lyden PD, Kasner SE. Prophylactic antiepileptic drug use is associated with poor outcome following ICH. Neurocrit Care. 2009;11:38–44.

    CAS  CrossRef  Google Scholar 

  35. de Freitas GR, Bogousslavsky J. Risk factors of cerebral vein and sinus thrombosis. Front Neurol Neurosci. 2008;23:23–54.

    PubMed  Google Scholar 

  36. Preter M, Tzourio C, Ameri A, Bousser MG. Long-term prognosis in cerebral venous thrombosis. Follow-up of 77 patients. Stroke. 1996;27:243–6.

    CAS  CrossRef  Google Scholar 

  37. Baumgartner RW, Studer A, Arnold M, Georgiadis D. Recanalisation of cerebral venous thrombosis. J Neurol Neurosurg Psychiatry. 2003;74:459–61.

    CAS  CrossRef  Google Scholar 

  38. Wu YW, Hamrick SE, Miller SP, Haward MF, Lai MC, Callen PW, Barkovich AJ, Ferriero DM. Intraventricular hemorrhage in term neonates caused by sinovenous thrombosis. Ann Neurol. 2003;54:123–6.

    CrossRef  Google Scholar 

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Wang, Y. (2019). Drug Therapy of Cerebral Venous Thrombosis. In: , et al. Cerebral Venous System in Acute and Chronic Brain Injuries. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-96053-1_18

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  • DOI: https://doi.org/10.1007/978-3-319-96053-1_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-96052-4

  • Online ISBN: 978-3-319-96053-1

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