Abstract
Currently, neuroprotective strategies mainly aim to decrease bleeding from cerebral arteries and protect the insulted neurons in the hemorrhagic stroke. However, the role of cerebral venous system in the pathophysiology of hemorrhagic stroke remains unclear. In this chapter, we summarize the relationship between cerebral venous system and hemorrhagic stroke, and aim to improve the diagnosis and management of hemorrhagic stroke by using multidisciplinary treatment approach. With several cases, including venous cavernoma, developmental venous anomalies, etc., presented in this chapter, the management of hemorrhagic stroke should be expanded from the cerebral arterial system to the balance between the cerebral arterial system and the cerebral venous system. Our aim is to establish an integrative concept in the clinical management of hemorrhagic stroke.
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Godoy DA, Pinero G, Di Napoli M. Predicting mortality in spontaneous intracerebral hemorrhage: can modification to original score improve the prediction? Stroke. 2006;37(4):1038–44.
Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006;5(1):53–63.
Andres RH, Guzman R, Ducray AD, Mordasini P, Gera A, Barth A, Widmer HR, Steinberg GK. Cell replacement therapy for intracerebral hemorrhage. Neurosurg Focus. 2008;24(3-4):E16.
Washington CW, Zipfel GJ, Participants in the International Multi-disciplinary Consensus Conference on the Critical Care Management of Subarachnoid Hemorrhage. Detection and monitoring of vasospasm and delayed cerebral ischemia: a review and assessment of the literature. Neurocrit Care. 2011;15(2):312–7.
Macdonald RL. Delayed neurological deterioration after subarachnoid haemorrhage. Nat Rev Neurol. 2014;10(1):44–58.
Ostergaard L, Aamand R, Karabegovic S, Tietze A, Blicher JU, Mikkelsen IK, Iversen NK, Secher N, Engedal TS, Anzabi M, Jimenez EG, Cai C, Koch KU, Naess-Schmidt ET, Obel A, Juul N, Rasmussen M, Sorensen JC. The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2013;33(12):1825–37.
Si Z, Luan L, Kong D, Zhao G, Wang H, Zhang K, Yu T, Pang Q. MRI-based investigation on outflow segment of cerebral venous system under increased ICP condition. Eur J Med Res. 2008;13(3):121–6.
Li Q, Khatibi N, Zhang JH. Vascular neural network: the importance of vein drainage in stroke. Transl Stroke Res. 2014;5(2):163–6.
Liu S, Connor J, Peterson S, Shuttleworth CW, Liu KJ. Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion. J Cereb Blood Flow Metab. 2002;22(10):1222–30.
Ishikawa M, Kusaka G, Yamaguchi N, Sekizuka E, Nakadate H, Minamitani H, Shinoda S, Watanabe E. Platelet and leukocyte adhesion in the microvasculature at the cerebral surface immediately after subarachnoid hemorrhage. Neurosurgery. 2009;64(3):546–53; discussion 553-4.
Mayhan WG, Heistad DD. Role of veins and cerebral venous pressure in disruption of the blood-brain barrier. Circ Res. 1986;59(2):216–20.
Usman U, Wasay M. Mechanism of neuronal injury in cerebral venous thrombosis. J Pak Med Assoc. 2006;56(11):509–12.
Wachtel M, Frei K, Ehler E, Fontana A, Winterhalter K, Gloor SM. Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition. J Cell Sci. 1999;112(Pt 23):4347–56.
de Bruijn SF, Stam J, Kappelle LJ. Thunderclap headache as first symptom of cerebral venous sinus thrombosis. CVST Study Group. Lancet. 1996;348(9042):1623–5.
Pradhan S, Yadav R, Diwakar H, Phadke RV. Subarachnoid hemorrhage following chronic dural venous sinus thrombosis. Angiology. 2007;58(4):498–501.
Ulrich ND, Lapeyre ER, Moore RC. Hemorrhagic stroke resulting from venous malformation at 20 weeks of pregnancy. Ochsner J. 2016;16(4):542–4.
James AH, Bushnell CD, Jamison MG, Myers ER. Incidence and risk factors for stroke in pregnancy and the puerperium. Obstet Gynecol. 2005;106(3):509–16.
Kittner SJ, Stern BJ, Feeser BR, Hebel R, Nagey DA, Buchholz DW, Earley CJ, Johnson CJ, Macko RF, Sloan MA, Wityk RJ, Wozniak MA. Pregnancy and the risk of stroke. N Engl J Med. 1996;335(11):768–74.
Leblanc GG, Golanov E, Awad IA, Young WL, Biology of Vascular Malformations of the Brain NINDS Workshop Collaborators. Biology of vascular malformations of the brain. Stroke. 2009;40(12):e694–702.
Kalani MY, Zabramski JM. Risk for symptomatic hemorrhage of cerebral cavernous malformations during pregnancy. J Neurosurg. 2013;118(1):50–5.
Li X, Wang Y, Chen W, Wang W, Chen K, Liao H, Lu J, Li Z. Intracerebral hemorrhage due to developmental venous anomalies. J Clin Neurosci. 2016;26:95–100.
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Qu, Y., Zhao, L., Guo, H. (2019). Role of Cerebral Venous System in Hemorrhagic Stroke. In: Lou, M., et al. Cerebral Venous System in Acute and Chronic Brain Injuries. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-96053-1_11
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DOI: https://doi.org/10.1007/978-3-319-96053-1_11
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