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Neuromuscular Diseases: Neuroanatomic and Differential Diagnoses

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Abstract

Neuromuscular diseases can be defined as those which affect the lower motor neuron or anterior horn cell (AHC), roots and root ganglia, plexus, nerves, neuromuscular junction and muscle. This covers an immense array of illnesses: degenerative, genetic, immune, infectious, metabolic, neoplastic, nutritional, paraneoplastic, traumatic, toxic, and vasculitic. Clearly, a thorough review is neither possible nor intended. An approach to patients with these disorders will be outlined with the major emphasis placed on the history and neurologic examination. The method used herein will be case presentations followed by case analysis.

Keywords

Demyelination Myopathy Myotonia Neuromuscular junction Neuropathy Plexopathy Radiculopathy 

References

  1. 1.
    Atkinson D, Glumak J, Asselbergh B, et al. Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. Neurology. 2017;88:533–42.CrossRefGoogle Scholar
  2. 2.
    Bird SJ, Rich MM. Neuromuscular complications of critical illness. Neurologist. 2000;6:2–11.CrossRefGoogle Scholar
  3. 3.
    Callaghan BC, Price RS, Chen KS, Feldman EL. The importance of rare subtypes in diagnosis and treatment of peripheral neuropathy. A review. JAMA Neurol. 2015;72:1510–18.CrossRefGoogle Scholar
  4. 4.
    Chusid JG. Correlative Neuroanatomy and Functional Neurology. 15th ed. Los Altos, CA: Lang Medical; 1973.Google Scholar
  5. 5.
    Engel WK, Askanas V. Inclusion body myositis: clinical, diagnostic, and pathologic aspects. Neurology. 2006;66(2 Suppl 1):520–29.Google Scholar
  6. 6.
    Gilhus NE. Myasthenia gravis. N Engl J Med. 2016;375:2570–81.CrossRefGoogle Scholar
  7. 7.
    Karpati G, Hilton-Jones D, Bushby K, Griggs RC. Disorders of Voluntary Muscle. 8th ed. New York: Cambridge University Press; 2010.CrossRefGoogle Scholar
  8. 8.
    Li J, Krajewski K, Lewis RA, Shy ME. Loss-of-function phenotype of hereditary neuropathy with liability to pressure palsies. Muscle Nerve. 2004;29:205–10.CrossRefGoogle Scholar
  9. 9.
    Mauerman M. Paraproteinemic Neuropathies. Continuum: lifelong learning in. Neurology. 2014;20:1307–22.Google Scholar
  10. 10.
    Rider LG, Miller FW. Deciphering the clinical presentations, pathogenesis, and treatment of the idiopathic inflammatory myopathies. JAMA. 2011;305:183–90.CrossRefGoogle Scholar
  11. 11.
    Ropper AH, Gorson KC. Neuropathies associated with paraproteinemia. N Engl J Med. 1998;338:1601–7.CrossRefGoogle Scholar
  12. 12.
    Rosenbaum R. Neuromuscular complications of connective tissue disease. Muscle Nerve. 2001;24:154–69.CrossRefGoogle Scholar
  13. 13.
    Ruts L, Drenthen J, Jacobs BC, Van Doorn PA. Distinguishing acute onset CIDP from fluctuating Guillain-Barré syndrome. Neurology. 2010;74:1680–6.CrossRefGoogle Scholar
  14. 14.
    Selim MH. Neurologic aspects of thyroid disease. Neurologist. 2001;7:135–46.CrossRefGoogle Scholar
  15. 15.
    Shaibani A. A Video Atlas of Neuromuscular Disorders. New York: Oxford University Press; 2014.Google Scholar
  16. 16.
    Stewart JD. Focal peripheral neuropathies. 3rd ed. New York: Elsevier; 2000.Google Scholar
  17. 17.
    Vinik AJ. Diabetic Sensory and Motor Neuropathy. N Engl J Med. 2016;374:1455–64.CrossRefGoogle Scholar

Suggested Reading

  1. Clauw DJ. Fibromyalgia. A Clinical Review JAMA. 2014;311:1547–55.PubMedGoogle Scholar
  2. Lopez-Sola M, Pujol J, Wager TD, et al. Altered functional magnetic resonance imaging responses to nonpainful sensory stimulation in fibromyalgia patients. Arthritis Rheumatology. 2014;66:3200–9.CrossRefGoogle Scholar
  3. Nicolle MW. Myasthenia gravis Neurologist. 2002;8:2–21.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of Texas Medical, School at HoustonHoustonUSA

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