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Transporter-Targeted Prodrug Approach for Retina and Posterior Segment Disease

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Drug Delivery for the Retina and Posterior Segment Disease

Abstract

Prodrug strategy is used to increase the bioavailability of drugs either by increasing the passive absorption by improving physicochemical properties of the parent drug or making them substrates of active transporter. There have been numerous reports and clinical applications of various prodrugs for oral delivery. Transporter-mediated prodrug approach is still a new and not completely explored area in the case of ocular delivery. This chapter gives a brief snapshot of the transporter-mediated prodrug approach for ocular delivery of drugs. There is also brief account of other types of prodrugs used for improving ocular bioavailability.

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Author information

Authors and Affiliations

  1. USF College of Pharmacy, Tampa, FL, USA

    Andrea Burgess, Tanjm Azad & Sheeba Varghese Gupta

  2. Dr. B.B. Thakar Research Center, Tampa, FL, USA

    Nandish Pathak & Vipul Amin

Authors
  1. Andrea Burgess
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  2. Tanjm Azad
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  3. Nandish Pathak
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  4. Vipul Amin
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  5. Sheeba Varghese Gupta
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Corresponding author

Correspondence to Sheeba Varghese Gupta .

Editor information

Editors and Affiliations

  1. Faculty of Pharmacy, Sankalchand Patel University, Gujarat, India

    Jayvadan K. Patel

  2. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Vijaykumar Sutariya

  3. School of Medicine, Faculty of Health, Deakin University, Victoria, Australia

    Jagat Rakesh Kanwar

  4. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

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Burgess, A., Azad, T., Pathak, N., Amin, V., Gupta, S.V. (2018). Transporter-Targeted Prodrug Approach for Retina and Posterior Segment Disease. In: Patel, J., Sutariya, V., Kanwar, J., Pathak, Y. (eds) Drug Delivery for the Retina and Posterior Segment Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-95807-1_17

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