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Biodegradable Polymeric Implants for Retina and Posterior Segment Disease

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Drug Delivery for the Retina and Posterior Segment Disease

Abstract

Drug delivery to the retina and posterior segment of the eye is challenging as the traditional procedures involve frequent clinical visits and administration of medications, drugs, and other injections that could potentially increase chances of infection and intraocular hazards.

Biodegradable implants are explored to overcome these limitations, and these implants are formulated from biocompatible polymers which can achieve a sustained release of therapeutic agent in ocular target site such as the retina or posterior segment of the eye with minimal side effects. These polymers are not toxic and can be broken down via enzymatic activity as well as hydrolysis within our body in months or years, and therefore, they have sufficient biocompatibility, especially when incorporated in systems for posterior eye disorders. This chapter discusses about examples of such implants, their formulation, material used, advantages, disadvantages, and possible toxicity profile as well as use of biodegradable polymeric implants in drug delivery for the retina and posterior segment of the eye.

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Authors and Affiliations

  1. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Aditi Pandhare, Priyanka Bhatt & Yashwant V. Pathak

  2. Department of Pharmaceutical Sciences, Southwestern Oklahoma State University College of Pharmacy, Weatherford, OK, USA

    Hardeep Singh Saluja

Authors
  1. Aditi Pandhare
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  2. Priyanka Bhatt
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  3. Hardeep Singh Saluja
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  4. Yashwant V. Pathak
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Corresponding author

Correspondence to Yashwant V. Pathak .

Editor information

Editors and Affiliations

  1. Faculty of Pharmacy, Sankalchand Patel University, Gujarat, India

    Jayvadan K. Patel

  2. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Vijaykumar Sutariya

  3. School of Medicine, Faculty of Health, Deakin University, Victoria, Australia

    Jagat Rakesh Kanwar

  4. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

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Pandhare, A., Bhatt, P., Saluja, H.S., Pathak, Y.V. (2018). Biodegradable Polymeric Implants for Retina and Posterior Segment Disease. In: Patel, J., Sutariya, V., Kanwar, J., Pathak, Y. (eds) Drug Delivery for the Retina and Posterior Segment Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-95807-1_15

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