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MicroRNAs as Regulators of Prostate Cancer Metastasis

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Cell & Molecular Biology of Prostate Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1095))

Abstract

Prostate cancer causes significant morbidity in men and metastatic disease is a major cause of cancer related deaths. Prostate metastasis is controlled by various cellular intrinsic and extrinsic factors, which are often under the regulatory control of various metastasis-associated genes. Given the dynamic nature of metastatic cancer cells, the various factors controlling this process are themselves regulated by microRNAs which are small non-coding RNAs. Significant research work has shown differential microRNA expression in primary and metastatic prostate cancer suggesting their importance in prostate pathogenesis. We will review the roles of different microRNAs in controlling the various steps in prostate metastasis.

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Acknowledgements

We thank Dr. Roger Erickson for his support with preparation of the manuscript. Research in authors’ lab is supported by the National Cancer Institute at the NIH (Grant Number RO1CA177984).

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Authors and Affiliations

  1. Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, California, USA

    Divya Bhagirath, Thao Ly Yang, Rajvir Dahiya & Sharanjot Saini

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  1. Divya Bhagirath
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  2. Thao Ly Yang
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Correspondence to Sharanjot Saini .

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  1. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Heide Schatten

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Bhagirath, D., Yang, T.L., Dahiya, R., Saini, S. (2018). MicroRNAs as Regulators of Prostate Cancer Metastasis. In: Schatten, H. (eds) Cell & Molecular Biology of Prostate Cancer. Advances in Experimental Medicine and Biology, vol 1095. Springer, Cham. https://doi.org/10.1007/978-3-319-95693-0_5

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