Skip to main content

Impact of Rheumatic Musculoskeletal Disease on Biological and Neurocognitive Development in Adolescents and Young Adults

  • Chapter
  • First Online:
Book cover Adolescent and Young Adult Rheumatology In Clinical Practice

Part of the book series: In Clinical Practice ((ICP))

  • 571 Accesses

Abstract

Core to the understanding of the impact of chronic rheumatic musculoskeletal disease (RMD) in adolescents and young adults (AYA) is the acknowledgement of the impact of such diseases on puberty and growth. Recent advances in neuroscience have also enhanced our understanding of brain development during the second and third decades of life and informs how we communicate and engage with young people appropriate to their stage of cognitive development. This chapter reviews puberty and growth in the context of RMD and provides the clinical practitioners signposts and strategies for the assessment and management of AYA with RMD.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 34.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 44.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Simon D, Fernando C, Czernichow P, Prieur AM. Linear growth and final height in patients with systemic juvenile, idiopathic arthritis treated with long-term glucocorticoids. J Rheumatol. 2002;29:1296–300.

    CAS  PubMed  Google Scholar 

  2. Keane VA. Assessment of growth. In: Stanton BF, Geme JF, Nina F, Schor NF, Kliegman RM, editors. Nelson textbook of pediatrics E-Book. Philadelphia: Elsevier; 2016. p. 84–9.

    Google Scholar 

  3. Biro FN, Kiess W. Contemporary trends in onset and completion of puberty, gain in height and adiposity. Endocr Dev. 2016;29:122–33.

    Article  Google Scholar 

  4. Livadas S, Chrousos GP. Control of the onset of puberty. Curr Opin Pediatr. 2016;28(4):551–8.

    Article  CAS  Google Scholar 

  5. Maher SE, Ali FI. Sexual maturation in Egyptian boys and girls with juvenile rheumatoid arthritis. Rheumatol Int. 2013;33:2123–6.

    Article  Google Scholar 

  6. McErlane F, Carrasco R, Kearsley-Fleet L, Baildam E, Wedderburn L, Foster H, et al. Growth patterns in early juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study (CAPS). Semin Arthritis Rheum. 2017; https://doi.org/10.1016/j.semarthrit.2017.11.002.S00490172(17)30371-2.

  7. Mairs R, Nicholls D. Assessment and treatment of eating disorders in children and adolescents. Arch Dis Child. 2016;101:1168–75.

    Article  Google Scholar 

  8. Cramblitt B, Pritchard M. Media’s influence on the drive for muscularity in undergraduates. Eat Behav. 2013;14:441–6.

    Article  Google Scholar 

  9. Guzman J, Kerr T, Ward LM, Ma J, Oen K, Rosenberg A, et al. Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort. Pediatr Rheumatol. 2017; https://doi.org/10.1186/s12969-017-0196-7s.

  10. Gaspari S, Marcovecchio ML, Breda L, Chiarelli F. Growth in juvenile idiopathic arthritis: the role of inflammation. Clin Exp Rheumatol. 2011;29:104–10.

    PubMed  Google Scholar 

  11. Wong SC, Dobie R, Altowati MA, Werther GA, Farquharson C, Ahmed SF. Growth and the growth hormone-insulin like growth factor 1 axis in children with chronic inflammation: current evidence, gaps in knowledge and future directions. Endocr Rev. 2016;37(1):62–110.

    Article  CAS  Google Scholar 

  12. Rygg M, Pistorio A, Ravelli A, Maghnie M, Di Iorgi N, Bader-Meunier B, et al. A longitudinal PRINTO study on growth and puberty in juvenile systemic lupus erythematosus. Ann Rheum Dis. 2012;71:511–7.

    Article  Google Scholar 

  13. De Benedetti F, Brunner H, Ruperto N, Schneider R, Xavier R, Allen R, et al. Catch-up growth during tocilizumab therapy for systemic juvenile idiopathic arthritis: results from a phase III trial. Arthritis Rheumatol. 2015;67:840–8.

    Article  Google Scholar 

  14. Uettwiller F, Perlbarg J, Pinto G, Bader-Meunier B, Mouy R, Compeyrot-Lacassagne S, et al. Effect of biologic treatments on growth in children with juvenile idiopathic arthritis. J Rheumatol. 2014;41:128–35.

    Article  Google Scholar 

  15. Zhang Y, Milojevic D. Protecting bone health in pediatric rheumatic disease: pharmacological considerations. Pediatr Drugs. 2017;19:193–211.

    Article  Google Scholar 

  16. Seitsalo S, Osterman K, Hyvãrinen H, Tallroth K, Schlenzka D, Poussa M. Progression of spondylolisthesis in children and adolescents. A long-term follow-up of 272 patients. Spine (Phila Pa 1976). 1991;16(4):417–21.

    Article  CAS  Google Scholar 

  17. Swain M, Kamper SJ, Maher CG, Broderick C, McKay D, Henschke N. Relationship between growth, maturation and musculoskeletal conditions in adolescents: a systematic review. Br J Sports Med. 2018;52:1246–52.

    Article  Google Scholar 

  18. Ferraù F, Korbonits M. Metabolic comorbidities in Cushing’s syndrome. Eur J Endocrinol. 2015;173:M133–57.

    Article  Google Scholar 

  19. Kelsey MM, Zeitler PS. Insulin resistance of puberty. Curr Diab Rep. 2016;16:64. https://doi.org/10.1007/s11892-016-0751-5.

    Article  CAS  PubMed  Google Scholar 

  20. Bismuth E, Chevenne D, Czernichow P, Simon D. Moderate deterioration in glucose tolerance during high-dose growth hormone therapy in glucocorticoid treated patients with juvenile idiopathic arthritis. Horm Res Paediatr. 2010;73:465–72.

    Article  CAS  Google Scholar 

  21. Stone S, Khamashta MA, Nelson-Piercy C. Non-steroidal anti-inflammatory drugs and reversible female infertility; Is there a link? Drug Saf. 2002;25(8):545–51.

    Article  CAS  Google Scholar 

  22. Schipper HM. The impact of gonadal hormones on the expression of human neurological disorders. Neuroendocrinology. 2016;103:417–31.

    Article  CAS  Google Scholar 

  23. Canadian Paediatric Society. Adolescent sexual orientation. Paediatr Child Health. 2008;13:619–23.

    Article  Google Scholar 

  24. de Bastos M, Stegeman BH, Rosendaal FR, Van Hylckama, Vlieg A, Helmerhorst FM, et al. Combined oral contraceptives: venous thrombosis.Cochrane Database Syst Rev. 2014;(3):CD010813. https://doi.org/10.1002/14651858.CD010813.pub2.

  25. WHO: Medical eligibility for contraceptive use. Publication date: August 2015 ISBN: 978 92 4 154915 8; Programmes/Sexual and Reproductive Health http://www.who.int/en/. Accessed 25 Feb 2018.

  26. Ostensen M, Andreoli L, Brucato A, Cetin I, Chambers C, Clowse ME, et al. State of the art: reproduction and pregnancy in rheumatic diseases. Autoimmun Rev. 2014;14:376–86.

    Article  Google Scholar 

  27. Modesto W, Bahamondes MV, Bahamondes L. Prevalence of low bone mass and osteoporosis in long-term users of the injectable contraceptive depot medroxyprogesterone acetate. J Women’s Health. 2015;24:636–40.

    Article  Google Scholar 

  28. Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod. 2008;23:699–708.

    Article  Google Scholar 

  29. Sowers M, McConnell D, Gast K, Zheng H, Nan B, McCarthy JD, et al. Anti-Mullerian hormone and inhibin B variability during normal menstrual cycles. Fertil Steril. 2010;94:1482–6.

    Article  CAS  Google Scholar 

  30. Henes M, Froeschlin J, Taran FA, Brucker S, Rall KK, Xenitidis T, et al. Ovarian reserve alterations in premenopausal women with chronic inflammatory rheumatic diseases: impact of rheumatoid arthritis, Behcet’s disease and spondyloarthitis on anti-Mullerian hormone levels. Rheumatology. 2015;54:1709–12.

    Article  CAS  Google Scholar 

  31. Ostensen M. Sexual and reproductive health in rheumatic disease. Nat Rev Rheumatol. 2017; https://doi.org/10.1038/nrrheum.102.

  32. Weber-Schoendorfer C, Chambers C, Wacker E, Beghin D, Bernard N. On behalf of the network of French pharmacovigilance centers. Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: a prospective multicenter cohort study. Arthritis Rheumatol. 2014;66:1101–10. https://doi.org/10.1002/art.38368.

    Article  CAS  PubMed  Google Scholar 

  33. Leroy C, Rigot LM, Leroy M, Decanter C, Le Mapihan K, Parent AS, et al. Immunosuppressive drugs and fertility. Orphanet J Rare Dis. 2015;10:136.

    Article  Google Scholar 

  34. Gutierrez J, Hwang K. The toxicity of methotrexate in male fertility and paternal teratogenicity. Expert Opin Drug Metab Toxicol. 2017;13(1):51–8.

    Article  CAS  Google Scholar 

  35. Weber-Schoendorfer C, Hoeltzenbein M, Wacker E, Meister R, Schaefer C. No evidence for an increased risk of adverse pregnancy outcome after paternal low-dose methotrexate: an observational cohort study. Rheumatology. 2014;53(1 1):757–63.

    Article  CAS  Google Scholar 

  36. Giedd JN. The amazing teen brain. Sci Am. 2015;312(6):32–7.

    Article  Google Scholar 

  37. Herting M, Sowell E. Puberty and structural brain development in humans. Front Neuroendocrinol. 2017;44:122–37.

    Article  Google Scholar 

  38. Steinberg L. The influence of neuroscience on US Supreme Court decisions about adolescents’ criminal culpability. Nat Rev Neurosci. 2013;14(7):513–8.

    Article  CAS  Google Scholar 

  39. Levy DM, Ardoi SP, Schanberg LE. Neurocognitive impairment in children and adolescents with systemic lupus erythematosus. Nat Clin Pract Rheumatol. 2009;5:106–14.

    Article  Google Scholar 

  40. Tarokh L, Saletin JM, Carskadon MA. Sleep in adolescence: physiology, cognition and mental health. Neurosci Biobehav Rev. 2016;70:182–6.

    Article  Google Scholar 

  41. Bartel KA, Gradisar M, Willaimson P. Protective and risk factors for adolescent sleep: a meta-analytic review. Sleep Med Rev. 2015;21:72–85.

    Article  Google Scholar 

  42. Health Education England. Adolescent health Programme module AH02; healthy development: session 02_006 assessing developmental stage. https://www.e-lfh.org.uk/programmes/adolescent-health/. Last accessed 15 June 2018.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kate Steinbeck .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

McKay, D., Steinbeck, K. (2019). Impact of Rheumatic Musculoskeletal Disease on Biological and Neurocognitive Development in Adolescents and Young Adults. In: McDonagh, J., Tattersall, R. (eds) Adolescent and Young Adult Rheumatology In Clinical Practice. In Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-95519-3_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-95519-3_1

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-95518-6

  • Online ISBN: 978-3-319-95519-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics