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Mechanics of the Cell Nucleus

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Biomechanics in Oncology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1092))

Abstract

Nucleus is a specialized organelle that serves as a control tower of all the cell behavior. While traditional biochemical features of nuclear signaling have been unveiled, many of the physical aspects of nuclear system are still under question. Innovative biophysical studies have recently identified mechano-regulation pathways that turn out to be critical in cell migration, particularly in cancer invasion and metastasis. Moreover, to take a deeper look onto the oncologic relevance of the nucleus, there has been a shift in cell systems. That is, our understanding of nucleus does not stand alone but it is understood by the relationship between cell and its microenvironment in the in vivo-relevant 3D space.

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Acknowledgments

Authors are indebted to many colleagues and students for their input and perspectives of nuclear mechanics. Special thanks to Dr. Denis Wirtz at the Johns Hopkins University, who provided overall guidance of this chapter. We appreciated Geonhui Lee, Seong-Beom Han, Jung-Won Park, and Jeong-Ki Kim in the Applied Mechanobiology Group (AMG) at Korea University for in-depth discussion of cellular and nuclear mechanobiology. This work was supported by the KU-KIST Graduate School of Converging Science and Technology Program, the National Research Foundation of Korea (NRF-2016R1C1B2015018 and NRF-2017K2A9A1A01092963), and Korea University Future Research Grant.

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Authors and Affiliations

  1. Korea University, Seoul, Korea

    Dong-Hwee Kim & Jungwon Hah

  2. The Johns Hopkins University, Baltimore, MD, USA

    Denis Wirtz

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  1. Dong-Hwee Kim
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  2. Jungwon Hah
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  3. Denis Wirtz
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Correspondence to Dong-Hwee Kim .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA

    Cheng Dong

  2. Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Nastaran Zahir

  3. Department of Chemical and Biomolecular Engineering Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA

    Konstantinos Konstantopoulos

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Kim, DH., Hah, J., Wirtz, D. (2018). Mechanics of the Cell Nucleus. In: Dong, C., Zahir, N., Konstantopoulos, K. (eds) Biomechanics in Oncology. Advances in Experimental Medicine and Biology, vol 1092. Springer, Cham. https://doi.org/10.1007/978-3-319-95294-9_3

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