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Stem Cell-Based Organoid Models in Lung Development and Diseases

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Lung Stem Cell Behavior

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Abstract

The recent application of co-culture organoid systems in different organs has successfully helped in the in vitro cultivation of stem cell populations that were previously inaccessible. These co-culture organoid systems have provided a novel method for investigating the cellular and molecular mechanisms controlling the development, interaction, and function of these cell types. In the lung, organoid cultures have been recently used for cell-cell interaction studies. These cultures rely on the interactions between the lung stem cells and a putative niche cell that is important for their behavior, differentiation, and growth. The organoid systems have been used in the study of airway basal cells, but the applications of organoid systems for the study of other lung regions or cell types are still in its infancy. This chapter describes our current knowledge of the stem cell-based organoid models in lung development and diseases. It also describes recent advances in the embryonic lung-derived organoids, the adult lung-derived organoids, and organoids from iPSC-derived lung epithelial cells.

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  1. The University of Edinburgh-Zhejiang International campus (UoE-ZJU Institute), and Centre of Stem Cell and Regenerative Medicine Schools of Medicine & Basic Medicine, Zhejiang University, Haining, Zhejiang, China

    Ahmed El-Hashash

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El-Hashash, A. (2018). Stem Cell-Based Organoid Models in Lung Development and Diseases. In: Lung Stem Cell Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-95279-6_8

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