Predictive Markers and Targeted Therapies in Thyroid Cancer and Selected Endocrine Tumors

  • Juan C. Hernandez-PreraEmail author
  • Bruce M. Wenig


Endocrine tumors are ubiquitous and can arise in many organs such as the pituitary, the pancreas, the ovaries, the testicles, the thyroid, the parathyroid, and the adrenal glands. Many of these tumors retain the ability to secrete hormones which can be the source of their symptomatology. In this chapter, we will mainly cover biomarkers associated with thyroid cancer – the most common malignancy of the endocrine system – and briefly touch upon other tumors such as the parathyroid carcinoma and adrenal gland neoplasia.


Papillary thyroid carcinoma Follicular thyroid carcinoma Mitogen-activated protein kinase (MAPK) signaling pathway PI3K/Akt/mTOR signaling pathway Tyrosine kinase inhibitors Adrenocortical carcinoma Parathyroid carcinoma Pheochromocytoma Paraganglioma 



We would like to thank Dr. Janis de la Iglesia from the Department of Head and Neck/Endocrine Cancer at Moffitt Cancer Center for creating Fig. 45.1 of this chapter.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Anatomic PathologyMoffitt Cancer Center, University of South FloridaTampaUSA

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